ID A0A096NMV0_PAPAN Unreviewed; 968 AA.
AC A0A096NMV0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=TBC1 domain family member 2B {ECO:0000313|Ensembl:ENSPANP00000014310.2};
GN Name=TBC1D2B {ECO:0000313|Ensembl:ENSPANP00000014310.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000014310.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000014310.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000014310.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A096NMV0; -.
DR STRING; 9555.ENSPANP00000014310; -.
DR Ensembl; ENSPANT00000027244.3; ENSPANP00000014310.2; ENSPANG00000015846.3.
DR eggNOG; KOG2058; Eukaryota.
DR GeneTree; ENSGT00940000157737; -.
DR HOGENOM; CLU_011278_0_0_1; -.
DR OMA; MMRCVEL; -.
DR OrthoDB; 616243at2759; -.
DR Proteomes; UP000028761; Chromosome 7.
DR Bgee; ENSPANG00000015846; Expressed in thymus and 65 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0006897; P:endocytosis; IEA:Ensembl.
DR CDD; cd01265; PH_TBC1D2A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR PANTHER; PTHR47219:SF16; TBC1 DOMAIN FAMILY MEMBER 2B; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761}.
FT DOMAIN 33..138
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 661..855
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 404..438
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 478..533
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 259..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 968 AA; 110394 MW; 65F635AA26578DC0 CRC64;
MPGAGSRAEE GGGGEGAAQG AAAEPGAGPA REPARLCGYL QKLSGKGPLR GYRSRWFVFD
ARRCYLYYFK SPQDALPLGH LDIADACFSY QGPDEAAELG AEPPAHFQVH SAGAVTVLKA
PNRQLMTYWL QELQQKRWEY CNSLDMVKWD SRTSPTPGDF PKGLVARDNT DLIYPHPNAS
AEKARNVLAV ETVPGELVGE QAANQPAPGH PNSINFYSLK QWGNELKNSM SSFRPGRGHN
DGRRTVFYTN EEWELLDPTP KDLEESVVQE EKKKLTPEGN KGVTGSGFPF DFGRNPYKGK
RPLKDIIGSY KNRHSSGDPS SEGTSGSGSI SIRKPGSEMQ LQIQSQQEEL ERLKKDLCSQ
KELVRLLQQT VRSSQYDKYF TSSRLCEGVP KDTLELLHQK DDQILGLTSQ LERFNLEKES
LQQEVRTLKS KVGELNEQLG MLMETIQAKD EVIIKLSEGE GSGPPPTVVP SSPSAAPVAR
DQLELDRLKD NLQGYKTQNK FLNKEILELS ALRRNAERRE RDLMAKYSSL EAKLCQIESK
YLILLQEMKT PVCSEDQGPT REVIAQLLED ALQVESQEQP EQAFVKPHLV SEYDIYGFRT
VPEDDEEEKL VAKVRALDLK TLYLTENQEV STGVKWENYF ASTVNREMMC SPELKNLIRA
GIPHEHRSKV WKWCVDRHTR KFKDSTEPGH FQTLLQKALE KQNPASKQIE LDLLRTLPNN
KHYSCPTSEG IQKLRNVLLA FSWRNPDIGY CQGLNRLVAV ALLYLEQEDA FWCLVTIVEV
FMPRDYYTKT LLGSQVDQRV FRDLMSEKLP RLHGHFEQYK VDYTLITFNW FLVVFVDSVV
SDILFKIWDS FLYEGPKVIF RFALALFKYK EEEILKLQDS MSIFKYLRYF TRTILDARKL
ISISFGDLNP FPLRQIRNRR AYHLEKVRLE LTELEAIRED FLRERDTSPD KDYWAALSPA
CRVPGVAR
//
