ID A0A096NQG2_PAPAN Unreviewed; 4265 AA.
AC A0A096NQG2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Dynein axonemal heavy chain 1 {ECO:0000313|Ensembl:ENSPANP00000015258.3};
GN Name=DNAH1 {ECO:0000313|Ensembl:ENSPANP00000015258.3};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000015258.3, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000015258.3, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000015258.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, cilium
CC axoneme {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 9555.ENSPANP00000015258; -.
DR Ensembl; ENSPANT00000020901.3; ENSPANP00000015258.3; ENSPANG00000004618.3.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000154791; -.
DR HOGENOM; CLU_000038_3_1_1; -.
DR OMA; HNVAKMV; -.
DR Proteomes; UP000028761; Chromosome 2.
DR Bgee; ENSPANG00000004618; Expressed in ventromedial nucleus of hypothalamus and 15 other cell types or tissues.
DR GO; GO:0036156; C:inner dynein arm; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0036126; C:sperm flagellum; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0036159; P:inner dynein arm assembly; IEA:Ensembl.
DR GO; GO:0007288; P:sperm axoneme assembly; IEA:Ensembl.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961:SF18; DYNEIN AXONEMAL HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761}.
FT DOMAIN 1013..1416
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1543..1869
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2038..2157
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2412..2494
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2556..2815
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2831..3175
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3204..3425
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3669..3782
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3814..3953
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3959..4261
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3060..3122
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3369..3435
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 58..72
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4265 AA; 487229 MW; 9F735E84B00D99A8 CRC64;
MEQPNSKGCS PGRTPQGPEC SGAPGVQVGT HRGLEYNPEK ILPGSDYGLG NPPALDPKLP
HLSLPPAPPT LSDLGQPRKS PLTGNDKKYP LMKQRGYYSD ILSPGTLDQL GEVCRGPRMS
QNLLRQADLD KFTPRVGTFE VPEDFQERVE QQCIGSTTRL LAQTDFPLQA YEPKVQVPFQ
VLPGQRPRKI EIERRKQQYL SLDIEQLLFS QGIDSNKLMP RHLDPQHPQT IEQGHDPLFP
IYLPLKVFDN EDFDCRTPRE WINMGLEPGS LDRKPVPGKA LLPTDDFLGH EDPKSQKLKY
EWCEVGVLDY DEEKKLYLVH KTDEKGLVRD EMGRPILNAG VTPEGRPPLQ VCQYWVPRIQ
LLFCAEDPCV FAQRVVQANA LRKNTEALLL YNLYVDCMPS DGQRVISEQS LSKIKQWALS
TPRMRKGPSV LEHLSSLARE VNLDYERSMN KINFDHIVSS KPQTFSYVTL PKKEEEQVPE
QGLVSVPKYH FREQKEDFTF VSLLTRPEVI TALSKVRAEC NKVTTMSLFH SNLSKYSRLE
EFEQIQSQTF SQVQMFLKDS WISSLKVAMR SSLRDMSKGW YNLYETNWEV YLMSKLRKLM
ELVKYMLQDT LRFLVQDSLA SFSQFISDAC CSVLNCTDDM VWGDDLINSP YRPRKNPLFI
VDLVLDSSGV HYSTPLEQFE TSLLNLFDKG ILATHAVPQL EKLVMEDIFI SGDPLLESVG
LHEPLVEELR ATIASAVSKA MIPLQAYAKE YRKYLELNNN DIASFLKAYQ TQGLLAQEVR
EVVLTHLQEK EILDSSLPSS IIIGPFYINT DNVKQSLSKK RKALATSMLD ILAKNLHKEV
DSICDEFRSI SRKIYEKPNS IEELAELREW MKGIPERLVG LEEQIVKVMD DYQVMDEFLY
NLSSDDFNDK WIASNWPSKI LGQIELVQQQ HVEDEEKFRK IQIMDQNNFQ EKLEGLQLVV
AGFSIHVEIS RAHEIANEVR RVKKQLKDCQ QLAMLYNNRE RIFGLPITNY DKLSRMVKEF
QPYLDLWTTA SDWLRWSESW MNDPLSAIDA EQLEKNVVEA FKTMHKCVKQ FKDMPACQEV
ALDIRARIEE FKPYIPLIQG LRNPGMRNRH WETLSNQINI NVRPKANLTF ARCLEMNLQD
HIESISKVAE VAGKEYAIEQ ALDKMEKEWS TILFNVLPYK ATDTYILKSP DEASQLLDDH
IVMTQSMSFS PYKKPFEQRI NSWENKLKLT QEVLEEWLNC QRSWLYLEPI FSSEDINRQL
PVESKRYQTM ERIWKKIMKN AYENREVINV CSDLRMLDSL RDCNKILDLV QKGLSEYLET
KRSAFPRFYF LSDDELLEIL SQTKDPTAVQ PHLRKCFENI ARLLFQEDLE ITHMYSAEGE
EVQLSFSIYP SSNVEDWLQE VERSMKASVH DIIERAIRAY PTMLRTQWVL NWPGQVTIAG
CQTYWTMEVA EALEAGDLRS RLFPQLCQQL SDLVALVRGK LSRMQRAVLS ALIVIEVHAK
DVVSKLIQEN VVSVNDFEWI SQLRYYWTNN DLYIRAVNAE FIYGYEYLGN SGRLVITPLT
DRCYLTLTGA LHLKFGGAPA GPAGTGKTET TKDLGKALAI QTVVFNCSDQ LDFMAMGKFF
KGLASAGAWA CFDEFNRIDI EVLSVVAQQI TTIQKAQQQR VERFMFEGVE IPLVPSCAVF
ITMNPGYAGR TELPDNLKAL FRPVAMMVPD YAMIAEISLY SFGFNEASVL AKKITTTFKL
SSEQLSSQDH YDFGMRAVKT VISAAGNLKR ENPSMNEELI CLRAIRDVNV PKFLQEDLKL
FSGIVSDLFP TIKEEDTDYG ILDEAIREAC RNSNLKDVEG FLTKCIQLYE TTVVRHGLML
VGPTGSGKST CYRVLAAAMT SLKGQPSISG GMYEAVNYYV LNPKSITMGQ LYGEFDLLTH
EWTDGIFSSL IRAGAIASDT NKKWYMFDGP VDAVWIENMN TVLDDNKKLC LSSGEIIKLT
EAMTMMFEVQ DLAVASPATV SRCGMVYLEP SILGLMPFIE CWLKKLPPLL KPYEEHFKAL
FVSFLEESIS FVRSSVKEVI ASTNCNLTMS LLKLLDCFFK PFLPREGLKK IPSEKLSHVA
ELIEPWFIFS LIWSVGATGD SNGRTSFSHW LRLKMENEQL TLLFPEEGLV FDYRLEDAGI
SGTNDNEDEE EEYKQVAWVK WMDSSAPFTM VPDTNYCNII VPTMDTVQMS HLLDMLLTNK
KPVLCIGPTG TGKTLTISDK LLKNLALEYV SHFLTFSART SANQTQDVID SKLDKRRKGV
FGPPLGRNFI FFIDDLNMPA LETYGAQPPI ELLRQWMDHG GWYDRKIIGA FKNLVDINFV
CAMGPPGGGR NTITPRLMRH FNYLSFAEMD EVSKKRIFST ILGNWMNGLL GEKSYREPVP
GAPHIAHFTE PLVEATIMVY ATITSQLLPT PAKSHYTFNL RDLSKVFQGM LMADPAKVED
QVQLLRLWYH ENCRVFRDRL VNEEDRSWFD QLLKRCMEQW EVTFNKVCPF QPILYGDFMS
PGSDVKSYEL ITSESKMMQV IEEYIEDYNQ INTAKLKLVL FMDAMSHICR ISRTLRQALG
NALLLGVGGS GRSSLTRLAS HMAEYECFQI ELSKNYGMPE WREDVKKVLL KAGLQNLPIT
FLFSDTQIKN ESFLEDINNV LNSGDIPNLY TVDEQDQIVS TMRPYVQEQG LQPTKANLMA
AYTGRVRSNI HMVLCMSPIG EVFRARLRQF PSLVNCCTID WFNEWPAEAL KSVATMFLNE
IPELESSQEE IQGLIQVCVY IHQSVSKKCI EYLAELTRHN YVTPKSYLEL LHIFSILIGQ
KKLELKTAKN RMKSGLDKLL RTSEDVAKMQ EDLESMHPLL EEAAKDTMLT MEQIKVDTAV
AEETRNSVQT EEIKANEKAK KAQAIADDAQ KDLDEALPAL DAALASLRNL NKNDVTEVRA
MQRPPPGVKL VIEAVCIMKG IKPKKVPGEK PGTKVDDYWE PGKGLLQDPG RFLESLFKFD
KDNIGDVVIK AIQPYIDNEE FQPAAIAKVS KACTSICQWV RAMHKYHFVA KAVEPKRQAL
REAQDDLGVT QRILDEAKQR LREVEDGIAT MQAKYRECIT KKEELELKCE QCEQRLGRAG
KLINGLSDEK VRWQETVENL QYMLNNISGD VLVAAGFVAY LGPFTGQYRT VLYDSWVKQL
RSHNVPHTSE PTLIGTLGNP VKIRSWQIAG LPNDTLSVEN GVINQFSQRW THFIDPQSQA
NKWIKNMEKD NGLDVFKLSD RDFLRSMENA IRFGKPCLLE NVGEELDPAL EPVLLKQTYK
QQGNTVLKLG DTVIPYHEDF RMYITTKLPN PHYTPEIATK LTLINFTLSP SGLEDQLLGQ
VVAEERPDLE EAKNQLIISN AKMRQELKDI EDQILYRLSS SEGNPVDDME LIKVLEASKM
KAAEIQAKVR IAEQTEKDID LTRMEYIPVA VRTQILFFCV SDLANVDPMY QYSLEWFLNI
FLSGIANSER ADNLKKRISN INRYLTYSLY SNVCRSLFEK HKLMFAFLLC VRIMMNEGKI
NQSEWHYLLS GGSIQIMTEN PAPDWLSDRA WRDILALSNL PNFSSFSSDF VKHLSEFRVI
FDSLEPHREP LPGIWDKYLD QFQKLLVLRC LRGDKVTNAM QDFVATNLEP RFIEPQTANL
SVVFKDSNST TPLIFVLSPG TDPAADLYKF AEEMKFSKKL SAISLGQGQG PRAEAMMRSS
IERGKWVFFQ NCHLAPSWMP ALERLIEHIN PDKVHRDFRL WLTSLPSNKF PVSILQNGSK
MTIEPPRGVK ANLLKSYSSL SEDFLNSCHK VMEFKSLLLS LCLFHGNALE RRKFGPLGFN
IPYEFTDGDL RICISQLKMF LEEYDDIPYK VLKYTAGEIN YGGRVTDDWD RRCIMNILED
FYNPDVLSPE HSYSASGIYH QIPPTYDLHG YLSYIKSLPL NDMPEIFGLH DNANITFAQN
ETFALLGTII QLQPKSSSAG SRGREEIVED VTQNILLKVP EPINLQWVMT KYPVLYEESM
NTVLVQEVIR YNRLLQVITQ TLQDLLKALK GLVVMSSQLE LMAASLYNNT VPQLWSAKAY
PSLKPLSSWV MDLLQRLDFL QAWIQGGIPA VFWISGFFFP QAFLTGTLQN FARKFVISID
TISFDFKVML ETPSELTQRP QVGCYIHGLF LEGARWDPEA FQLAESQPKE LYTEMAVIWL
LPTPNRMAQD QDFYLCPIYK TLTRAGTLST TGHSTNYVIA VEIPTHQPQR HWIKRGVALI
CALDY
//
