ID A0A096NWB3_PAPAN Unreviewed; 888 AA.
AC A0A096NWB3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=Zinc finger FYVE-type containing 28 {ECO:0000313|Ensembl:ENSPANP00000017340.2};
GN Name=ZFYVE28 {ECO:0000313|Ensembl:ENSPANP00000017340.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000017340.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000017340.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000017340.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the lst-2 family.
CC {ECO:0000256|ARBA:ARBA00008755}.
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DR AlphaFoldDB; A0A096NWB3; -.
DR Ensembl; ENSPANT00000022186.3; ENSPANP00000017340.2; ENSPANG00000001128.3.
DR eggNOG; KOG1819; Eukaryota.
DR GeneTree; ENSGT00940000157217; -.
DR HOGENOM; CLU_007360_1_0_1; -.
DR OMA; PELGYDR; -.
DR OrthoDB; 5394048at2759; -.
DR Proteomes; UP000028761; Chromosome 3.
DR Bgee; ENSPANG00000001128; Expressed in postnatal subventricular zone and 13 other cell types or tissues.
DR ExpressionAtlas; A0A096NWB3; baseline.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031901; C:early endosome membrane; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Ensembl.
DR GO; GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR CDD; cd15731; FYVE_LST2; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR043269; FYVE_LST2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46465; LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG; 1.
DR PANTHER; PTHR46465:SF2; LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 818..874
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 354..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..627
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 888 AA; 96684 MW; A2545996EEAADF34 CRC64;
MMNRFRKWLY KPKRSDPQLL ARFYYADEEL NQVAAELDSL DGRKDPQRCT LLVSQFRSCQ
DNVLNIINQI MDECIPQDRA PRDFCVKFPE EIRHDNLAGQ LWFGAECLAA GSIIMNRELE
SMAMRPLAKE LTRSLEDVRG ALRDQALRDL NTYTEKMREA LRHFDVLFAE FELSYVSAMV
PVKSPREYYV QQEVIVLFCE TVERALDFGY LTQDMIDDYE PALMFSIPRL AIVCGLVVYA
DGPLNLDRKA EDMSELFRPF HTLLRKIRDL LQTLTEEELH TLERNLCISQ DVEFPIRADV
QGPAVLTPAL SAPLPPEGPL SVKAKDPDAE LACSMQYDDQ ELEQLSRMVH RAGDEMSSLL
SPPSACQSPA HRPGAEGSPG EEASPRKARL RSGSDEEERV FFMDDVEGTA EALARPESPG
GPFGWAGSIR ADPQEKGQGG PGGAAGVSVP ASEKEEDLSN NNNPEAEGTG GASLAGTSSC
SCLDSRLHLD GWEVGADDAE TAEMIAHRTG GMKLSATVIF NPKSPTSLDS AVATQEAASE
PVAEGMDGGP HKLSTAATNC LLHSCVCCGS CGDSREDVVE RLQEKCSPGG VIGASYAASL
AKASDRAAER QDEAPPPSED ASDGREPKAP TSNKCLPHTS GSQVDTASGL QGEAGVAGQQ
EPEVRELDAG SPSAHEAPQP LSGSSSSAAG SCSSDQMGPE VAPAATHVAP QATREKIRSR
FHGSHDLIHR LFVCISGVAD QLQTNYASDL RSILKTLFEV MATKPETDDK EKLRKVTQTL
RSAALEDCAL CQETLSSSEL AAKTRDGDFE DPPEWVPDEA CGFCMACKAP FTVIRRKHHC
RSCGKIFCSR CSSHSAPLPR YGQVKPVRVC THCYMFHVTP FYSDKAGL
//
