ID A0A096NYU4_PAPAN Unreviewed; 1721 AA.
AC A0A096NYU4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Nestin {ECO:0000313|Ensembl:ENSPANP00000018260.3};
GN Name=NES {ECO:0000313|Ensembl:ENSPANP00000018260.3};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000018260.3, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000018260.3, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000018260.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR STRING; 9555.ENSPANP00000018260; -.
DR Ensembl; ENSPANT00000025158.3; ENSPANP00000018260.3; ENSPANG00000016431.3.
DR eggNOG; ENOG502RYFK; Eukaryota.
DR GeneTree; ENSGT00940000162240; -.
DR HOGENOM; CLU_003317_0_0_1; -.
DR OMA; RKEGWDP; -.
DR Proteomes; UP000028761; Chromosome 1.
DR Bgee; ENSPANG00000016431; Expressed in aorta and 66 other cell types or tissues.
DR ExpressionAtlas; A0A096NYU4; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0019215; F:intermediate filament binding; IEA:InterPro.
DR GO; GO:0048858; P:cell projection morphogenesis; IEA:Ensembl.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR031211; Nestin.
DR PANTHER; PTHR47051; NESTIN; 1.
DR PANTHER; PTHR47051:SF1; NESTIN; 1.
DR Pfam; PF00038; Filament; 2.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761}.
FT DOMAIN 110..415
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 25..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 773..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1671..1693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 114..148
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 218..252
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 320..386
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 39..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..794
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..904
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1059
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1093
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1210..1250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1257..1291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1447..1471
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1509..1528
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1543..1559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1721 AA; 187885 MW; 4E403777C97BB687 CRC64;
MVGLLLWFHS PAPWGSRDRG CCHSLTSKGL RPGSRPSSRP PGGSMNSLAP TPDSQSLRLL
PPRPAPSLSP SVSFLFGPKS SVSRSLFLVP SVCPSSVGQT SRMEGCMGEE SFQMWELNRR
LEAYLGRVKA LEEQNELLSA ELGGLRAQSG DTSWRARADD ELAALRALVD QRWREKHAAE
VARDNLAEEL EGVVGRCQQL RLARERTAEE VARNRRAVEA EKCARAWLSR QAAELERELE
ALRLAHEEER IGLNAQAACA PRCPAPPRGP PAPAPEVEEL ARRLGEAWRG AVRGYQERVA
HMETSLGQAR ERLGRAVQGA REGRLELQQL QAERGGLQER RAALEQRLEG RWQERLRATE
KFQLAVEALE QEKQGLQSQI AQVLEGRQQL AHLKMSLSLE VATYRTLLEA ENSRLQTPGG
GSKTSLSFPD PKLELQFPGT PEGRRLGSLL PVLSPTSLPS PLPATLETPV PAFLKNQEFL
QARTPTLAST PIPPTPQAPS LATDAEIRAQ DAAVSLLQAQ GGRKQAPEPL QAEAKVAIPA
SVLPGPEEPG GQWQEAGTGQ SPEDHASLAP PVSPDHSSLE AKDGESGGSR VFSICQEEGE
GQIRGLVEKE TAIEGKMVSS LQQEIWEEQD LNRKEIQDSQ VPLEKETLKS LGEEIQESLK
TLENQSHETL ERENQESPRP LEEDLDTLKS LEKENKELLK HVEVVRPLEK EAVGLLKPIG
KEDTQTLQPL QKENQELMKS LEGNLETFLF PGKENQELVS SLQENLESLT ALEKENQEPL
RSLEVEDEEA LRSLTKVNQE PLRSLEDENQ EAFRPLEKEN QEPLNTLEEE DQSIVRPLET
ENHTSLRSLE EEDQETLRTL EKETQQPQRS LGEEDQMTLR PPEKVDPEPL KSFDQEIARP
LENENQELLK SLKEESVEAV KSLETELLQS LKSAGQENLE TSKSPETEAP LWSLEEINQG
TMKPLEIQEP LESVEVNQET LRLLEEENQE PLRSLGAWNL ENLRSPEEVD KESQRNLEEE
ENLGKGENQE SLRSLEEEGR ELPQSADVQR WEDTVGKDQE LFQESPAGMA GVENEDEAEL
NLREQDGFAG KEEVVEQGEA NATEEVWMPG EGHPGSPEPK EQRGLAEGAS GKGGAEGLQD
PKGQSQQVGA PGLQAPQGLP EAIEPLVEDE DVAPRGGQAS PEVTLGSEPA TGESAVGAEP
GPRQEVGGLE DSGHLTREEV MEPPLEEESL EAKRVQGLEG PRKDSEEAGA LGTELSELPR
KSRDPWESPK GWEESEAEAP REAEEAFPAE TLGHDGSDAP PPRPLGSEEA EKDVPPVLVS
PSPTYTPILE DAPGPQPQAE GSQEASWGVQ GRAEALGKVE SEQEELGSGE IPKGLQEEGE
ESREESEEDE LGETLPDSTP LGLYLRSPTS PKWDPTGEQR PPPQGKTGKE GWDPAALASK
GLEAPPSEEE EGEEGEEECG RDSDLSEEFE DLGTEASFLP GVPGEVAEPL GQVPQLLLEP
AAWDRDGESD GFADEEESGE EGEEDEEKGR EPEAGRWGPG SSVGSLQALS SSQRGDFLES
DSVGVSVPWD DGLRGAVAAA PMTALETESQ DSAEPSGSEE ESDPVSLERE DKVPGPLEVP
GGMEDSGPGA DIIGVNGQGP NLEEKSQHVN GGVMNGLEQS EEVGQGTLLV PEEDRGSPFQ
EEEGSALKTS WAGAPVHLGQ GQFLKFTQRE GDRESWSSGE D
//
