GenomeNet

Database: UniProt
Entry: A0A096NZ91_PAPAN
LinkDB: A0A096NZ91_PAPAN
Original site: A0A096NZ91_PAPAN 
ID   A0A096NZ91_PAPAN        Unreviewed;      1866 AA.
AC   A0A096NZ91;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   30-AUG-2017, entry version 25.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN1A {ECO:0000313|Ensembl:ENSPANP00000018412};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000018412, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000018412, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000018412}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPANP00000018412}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AHZZ01041788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000023924; ENSPANP00000018412; ENSPANG00000000722.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; CMSNHTT; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000028761; Chromosome 12.
DR   GO; GO:0043194; C:axon initial segment; IEA:Ensembl.
DR   GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0033268; C:node of Ranvier; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR   GO; GO:0050884; P:neuromuscular process controlling posture; IEA:Ensembl.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0019227; P:neuronal action potential propagation; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008051; Na_channel_a1su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01664; NACHANNEL1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18   1866       Sodium channel protein. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5001923455.
FT   TRANSMEM    119    139       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    268    295       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    627    645       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    657    675       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    737    765       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    824    850       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1077   1095       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1116   1135       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1191   1219       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1317   1341       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1400   1418       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1430   1448       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1460   1480       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1517   1545       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1621   1644       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        1    302       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      374    576       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      627    854       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      864   1071       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1075   1349       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1399   1654       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      292    337       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1866 AA;  212864 MW;  D03D745643FF5CE4 CRC64;
     MLIMCTILTN CVFMTMSNPP DWTKNVEYTF TGIYTFESLI KIIARGFCLE DFTFLRDPWN
     WLDFTVITFA YVTEFVDLGN VSALRTFRVL RALKTISVIP GLKTIVGALI QSVKKLSDVM
     ILTVFCLSVF ALIGLQLFMG NLRNKCIQWP PTNASLEEHS VEKNITVNYN GTLINETVFE
     FDWKSYIQDS RYHYFLEGFL DALLCGNSSD AGQCPEGYVC VKAGRNPNYG YTSFDTFSWA
     FLSLFRLMTQ DFWENLYQLT LRAAGKTYMI FFVLVIFLGS FYLINLILAV VAMAYEEQNQ
     ATLEEAEQKE AEFQQMIEQL KKQQEAAQQA ATATASEHSR EPSAAGRLSD SSSEASKLSS
     KSAKERRNRR KKRKQKEQSG GEEKDEDEFH KSESEDSIRR KGFRFSIEGN RLTYEKRYSS
     PHQSLLSIRG SLFSPRRNSR TSLFSFRGRA KDVGSENDFA DDEHSTFEDN ESRRDSLFVP
     RRHGERRNSN LSQTSRSSRM LAVFPANGKM HSTVDCNGVV SLVGGPSVPT SPVGQLLPEG
     TTTETEMRKR RSSSFHVSMD FLEDPSQRQR AMSIASILTN TVEELEESRQ KCPPCWYKFS
     NIFLIWDCSP YWLKVKHVVN LVVMDPFVDL AITICIVLNT LFMAMEHYPM TDHFNNVLTV
     GNLVFTGIFT AEMFLKIIAM DPYYYFQEGW NIFDGFIVTL SLVELGLANV EGLSVLRSFR
     LLRVFKLAKS WPTLNMLIKI IGNSVGALGN LTLVLAIIVF IFAVVGMQLF GKSYKDCVCK
     IASDCQLPRW HMNDFFHSFL IVFRVLCGEW IETMWDCMEV AGQAMCLTVF MMVMVIGNLV
     VLNLFLALLL SSFSADNLAA TDDDNEMNNL QIAVDRMHKG VAYVKRKIYE FIQQSFIRKQ
     KILDEIKPLD DLNNKKDSCM SNHTTEIGKD LDYLKDVNGT TSGIGTGSSV EKYIIDESDY
     MSFINNPSLT VTVPIAVGES DFENLNTEDF SSESDLEESK EKLNESSSSS EGSTVDIGAP
     AEEQPVVEPE ETLEPEACFT EGCVQRFKCC QINVEEGRGK QWWNLRRTCF RIVEHNWFET
     FIVFMILLSS GALAFEDIYI DQRKTIKTML EYADKVFTYI FILEMLLKWV AYGYQTYFTN
     AWCWLDFLIV DVSLVSLTAN ALGYSELGAI KSLRTLRALR PLRALSRFEG MRVVVNALLG
     AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK FYHCINTTTG DRFDIEDVNN HTDCLKLIER
     NETARWKNVK VNFDNVGFGY LSLLQVATFK GWMDIMYAAV DSRNVELQPK YEESLYMYLY
     FVIFIIFGSF FTLNLFIGVI IDNFNQQKKK FGGQDIFMTE EQKKYYNAMK KLGSKKPQKP
     IPRPGNKFQG MVFDFVTRQV FDISIMILIC LNMVTMMVET DDQSEYVTTI LSRINLVFIV
     LFTGECVLKL ISLRHYYFTI GWNIFDFVVV ILSIVGMFLA ELIEKYFVSP TLFRVIRLAR
     IGRILRLIKG AKGIRTLLFA LMMSLPALFN IGLLLFLVMF IYAIFGMSNF AYVKREVGID
     DMFNFETFGN SMICLFQITT SAGWDGLLAP ILNSKPPDCD PNKVNPGSSV KGDCGNPSVG
     IFFFVSYIII SFLVVVNMYI AVILENFSVA TEESAEPLSE DDFEMFYEVW EKFDPDATQF
     MEFEKLSQFA AALEPPLNLP QPNKLQLIAM DLPMVSGDRI HCLDILFAFT KRVLGESGEM
     DALRIQMEER FMASNPSKVS YQPITTTLKR KQEEVSAVII QRAYRRHLLK RTVKQASFTY
     NKNKIKGGAN LIKEDMIIDR INENSITEKT DLTMSTAACP PSYDRVTKPI VEKHEQEGKD
     EKAKGK
//
DBGET integrated database retrieval system