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Database: UniProt
Entry: A0A096NZ91_PAPAN
LinkDB: A0A096NZ91_PAPAN
Original site: A0A096NZ91_PAPAN 
ID   A0A096NZ91_PAPAN        Unreviewed;      1996 AA.
AC   A0A096NZ91;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 28.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN1A {ECO:0000313|Ensembl:ENSPANP00000018412};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000018412, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000018412, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000018412}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AHZZ02004055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000023924; ENSPANP00000018412; ENSPANG00000000722.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; CMSNHTT; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000028761; Chromosome 12.
DR   GO; GO:0043194; C:axon initial segment; IEA:Ensembl.
DR   GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0033268; C:node of Ranvier; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR   GO; GO:0050884; P:neuromuscular process controlling posture; IEA:Ensembl.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0019227; P:neuronal action potential propagation; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008051; Na_channel_a1su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01664; NACHANNEL1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    124    147       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    192    211       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    223    243       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    249    269       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    398    425       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    757    775       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    787    805       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    867    895       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    954    980       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1207   1225       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1246   1265       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1321   1349       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1447   1471       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1530   1548       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1560   1578       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1590   1610       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1647   1675       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1751   1774       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      127    432       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      504    706       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      757    984       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      994   1201       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1205   1479       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1529   1784       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      422    467       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1996 AA;  227587 MW;  9C69CBA7C2A7ADEC CRC64;
     MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK PNSDLEAGKN
     LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVLNKGKAIF RFSATSALYI LTPFNPLRKI
     AIKILVHSLF SMLIMCTILT NCVFMTMSNP PDWTKNVEYT FTGIYTFESL IKIIARGFCL
     EDFTFLRDPW NWLDFTVITF AFVTEFVNLG NFSALRTFRV LRVLKTSVIP GLKTIVGALI
     QSVKKLSDVM ILTVFCLSVF ALIGLQLFMG NLRNKCIQWP PTNASLEEHS VEKNITVNYN
     GTLINETVFE FDWKSYIQDS RYHYFLEGFL DALLCGNSSD AGQCPEGYVC VKAGRNPNYG
     YTSFDTFSWA FLSLFRLMTQ DFWENLYQLT LRAAGKTYMI FFVLVIFLGS FYLINLILAV
     VAMAYEEQNQ ATLEEAEQKE AEFQQMIEQL KKQQEAAQQA ATATASEHSR EPSAAGRLSD
     SSSEASKLSS KSAKERRNRR KKRKQKEQSG GEEKDEDEFH KSESEDSIRR KGFRFSIEGN
     RLTYEKRYSS PHQSLLSIRG SLFSPRRNSR TSLFSFRGRA KDVGSENDFA DDEHSTFEDN
     ESRRDSLFVP RRHGERRNSN LSQTSRSSRM LAVFPANGKM HSTVDCNGVV SLVGGPSVPT
     SPVGQLLPEG TTTETEMRKR RSSSFHVSMD FLEDPSQRQR AMSIASILTN TVEELEESRQ
     KCPPCWYKFS NIFLIWDCSP YWLKVKHVVN LVVMDPFVDL AITICIVLNT LFMAMEHYPM
     TDHFNNVLTV GNLVFTGIFT AEMFLKIIAM DPYYYFQEGW NIFDGFIVTL SLVELGLANV
     EGLSVLRSFR LLRVFKLAKS WPTLNMLIKI IGNSVGALGN LTLVLAIIVF IFAVVGMQLF
     GKSYKDCVCK IASDCQLPRW HMNDFFHSFL IVFRVLCGEW IETMWDCMEV AGQAMCLTVF
     MMVMVIGNLV VLNLFLALLL SSFSADNLAA TDDDNEMNNL QIAVDRMHKG VAYVKRKIYE
     FIQQSFIRKQ KILDEIKPLD DLNNKKDSCM SNHTTEIGKD LDYLKDVNGT TSGIGTGSSV
     EKYIIDESDY MSFINNPSLT VTVPIAVGES DFENLNTEDF SSESDLEESK EKLNESSSSS
     EGSTVDIGAP AEEQPVVEPE ETLEPEACFT EGCVQRFKCC QINVEEGRGK QWWNLRRTCF
     RIVEHNWFET FIVFMILLSS GALAFEDIYI DQRKTIKTML EYADKVFTYI FILEMLLKWV
     AYGYQTYFTN AWCWLDFLIV DVSLVSLTAN ALGYSELGAI KSLRTLRALR PLRALSRFEG
     MRVVVNALLG AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK FYHCINTTTG DRFDIEDVNN
     HTDCLKLIER NETARWKNVK VNFDNVGFGY LSLLQVATFK GWMDIMYAAV DSRNVELQPK
     YEESLYMYLY FVIFIIFGSF FTLNLFIGVI IDNFNQQKKK FGGQDIFMTE EQKKYYNAMK
     KLGSKKPQKP IPRPGNKFQG MVFDFVTRQV FDISIMILIC LNMVTMMVET DDQSEYVTTI
     LSRINLVFIV LFTGECVLKL ISLRHYYFTI GWNIFDFVVV ILSIVGMFLA ELIEKYFVSP
     TLFRVIRLAR IGRILRLIKG AKGIRTLLFA LMMSLPALFN IGLLLFLVMF IYAIFGMSNF
     AYVKREVGID DMFNFETFGN SMICLFQITT SAGWDGLLAP ILNSKPPDCD PNKVNPGSSV
     KGDCGNPSVG IFFFVSYIII SFLVVVNMYI AVILENFSVA TEESAEPLSE DDFEMFYEVW
     EKFDPDATQF MEFEKLSQFA AALEPPLNLP QPNKLQLIAM DLPMVSGDRI HCLDILFAFT
     KRVLGESGEM DALRIQMEER FMASNPSKVS YQPITTTLKR KQEEVSAVII QRAYRRHLLK
     RTVKQASFTY NKNKIKGGAN LIKEDMIIDR INENSITEKT DLTMSTAACP PSYDRVTKPI
     VEKHEQEGKD EKAKGK
//
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