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Database: UniProt
Entry: A0A096NZ92_PAPAN
LinkDB: A0A096NZ92_PAPAN
Original site: A0A096NZ92_PAPAN 
ID   A0A096NZ92_PAPAN        Unreviewed;      1662 AA.
AC   A0A096NZ92;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   30-AUG-2017, entry version 25.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN9A {ECO:0000313|Ensembl:ENSPANP00000018413};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000018413, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000018413, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000018413}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPANP00000018413}.
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DR   EMBL; AHZZ01041784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ01041785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ01041786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_009180626.1; XM_009182362.2.
DR   Ensembl; ENSPANT00000023923; ENSPANP00000018413; ENSPANG00000005059.
DR   GeneID; 101004494; -.
DR   CTD; 6335; -.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000028761; Chromosome 12.
DR   ExpressionAtlas; A0A096NZ92; baseline.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR028803; SCN9A.
DR   PANTHER; PTHR10037:SF235; PTHR10037:SF235; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     24     42       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     63     90       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    411    437       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    449    467       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    487    508       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    529    557       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    619    642       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    867    885       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    906    922       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    998   1018       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1067   1088       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1108   1131       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1190   1208       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1220   1238       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1245   1270       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1307   1335       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1411   1434       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       11     96       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      169    368       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      419    647       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      656    861       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      865   1140       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1189   1444       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       87    132       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1662 AA;  189864 MW;  A4BAF5C5006A74F2 CRC64;
     MFFFMCSQCP EGYTCMKIGR NPDYGYTSFD TFSWAFLALF RLMTQDYWEN LYQQTLRAAG
     KTYMIFFVVV IFLGSFYLIN LILAVVAMAY EEQNQANIEE AKQKELEFQQ MLDRLKKEQE
     EAEAIAAAAA EYTSIRRSRI MGLSESSSET SRLSSKSAKE RRNRRKKKNQ KKLSSGEEKG
     DAEKLSKSDS EENIRRKSFH LGVEGHRRAH EKRLSTPSQS PLSIRGSLFS ARRSSRTSLF
     SFKGRGRDIG SETEFADDEH SIFGDNESRR GSLFVPHRPQ ERRSSNISQA SRSPPMLPVN
     GKMHSAVDCN GVVSLVDGRS ALMLPNGQLL PEGTTNQIHK KRRCSSYLLS EDMLNDPNLR
     QRAMSRASIL TNTVEELEES RQKCPPWWYR FAHKFLIWNC SPYWIKFKKC IYFIVMDPFV
     DLAITICIVL NTLFMAMEHH PMTEEFKNVL AIGNLVFTGI FAAEMVLKLI AMDPYEYFQV
     GWNIFDSLIV TLSLVELFLA DVEGLSVLRS FRLLRVFKLA KSWPTLNMLI KIIGNSVGAL
     GNLTLVLAII VFIFAVVGMQ LFGKSYKECV CKINDDCTLP RWHMNDFFHS FLIVFRVLCG
     EWIETMWDCM EVAGQAMCLI VYMMVMVIGN LVVLNLFLAL LLSSFSSDNL TAIEEDPDAN
     NLQIAVTRIK MGINYVKQTL REFILKTFSK KPKISREIRQ TEDLNTKKEN YISNYTLAEM
     SKGHNFLKEK DKISGFGSCV DKYLMEDSDG QSFIHNPSLT VTVPIAPGES DLENMNTEEL
     SSDSDSEYSK VRLNQSSSSE CSTVDNPFPG EGEEAEAEPM NSDEPEACFT DGCVRRFSCC
     QVNIESGKGK IWWNIRKTCY KIVEHSWFES FIVLMILLSS GALAFEDIYI ERKKTIKIIL
     EYADKIFTYI FILEMLLKWI AYGYKTYFTN AWCWLDFLIV DVSLVTLVAN TLGYSDLGPI
     KSLRTLRALR PLRALSRFEG MRVVVNALIG AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK
     FYECINTTDG SRFPASQVPN RSECFALMNV SQNVRWKNLK VNFDNVGLGY LSLLQVATFK
     GWTIIMYAAV DSVNVDKQPR YEYSLYMYIY FVIFIIFGSF FTLNLFIGVI IDNFNQQKKK
     LGGQDIFMTE EQKKYYNAMK KLGSKKPQKP IPRPGNKIQG CIFDLVTNQA FDISIMVLIC
     LNMVTMMVEK EGQSLYMTDV LYWINVVFII LFTGECVLKL ISLRYYYFTI GWNIFDFVVV
     IISIVGMFLA DLIETYFVSP TLFRVIRLAR IGRILRLVKG AKGIRTLLFA LMMSLPALFN
     IGLLLFLVMF IYAIFGMSNF AYVKKEDGIN DMFNFETFGN SMICLFQITT SAGWDGLLAP
     ILNSKPPDCD PKKVHPGSSV EGDCGNPSVG IFYFVSYIII SFLVVVNMYI AVILENFSVA
     TEESTEPLSE DDFEMFYEVW EKFDPDATQF IEYNKLSDFA AALDPPLLIA KPNKVQLIAM
     DLPMVSGDRI HCLDILFAFT KRVLGESGEM DSLRSQMEER FMSANPSKVS YEPITTTLKR
     KQEDVSATVI QRAYRRYRLR QNVKNISSIY IKDGDRDDDL LNKKDMVFDN VNENSSPEKT
     DATSSTTSPP SYDSVTKPDK EKYEQDRTEK EDKGKDSKES KK
//
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