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Database: UniProt
Entry: A0A096P4K8_PAPAN
LinkDB: A0A096P4K8_PAPAN
Original site: A0A096P4K8_PAPAN 
ID   A0A096P4K8_PAPAN        Unreviewed;      2355 AA.
AC   A0A096P4K8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-SEP-2017, entry version 24.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1G {ECO:0000313|Ensembl:ENSPANP00000020283};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000020283, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000020283, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000020283}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPANP00000020283}.
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DR   EMBL; AHZZ01028109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ01028110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000018551; ENSPANP00000020283; ENSPANG00000022468.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; FWRLICD; -.
DR   OrthoDB; EOG091G02L1; -.
DR   Proteomes; UP000028761; Chromosome 16.
DR   ExpressionAtlas; A0A096P4K8; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0086056; F:voltage-gated calcium channel activity involved in AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086059; F:voltage-gated calcium channel activity involved SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0010045; P:response to nickel cation; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF256; PTHR10037:SF256; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    117    136       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    208    231       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    336    357       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    363    388       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    722    740       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    752    773       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    843    862       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    919    942       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1255   1273       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1293   1314       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1326   1345       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1390   1412       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1492   1515       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1590   1611       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1623   1646       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1724   1743       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1807   1829       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       75    399       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      721    947       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1253   1525       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1589   1839       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1524   1551       {ECO:0000256|SAM:Coils}.
FT   COILED     1828   1852       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2355 AA;  260118 MW;  FAF9244195FE400A CRC64;
     MDEEEDGAGA EESGQPRSFM RLNDLSAEKD PGSADSEAEG LPYPALAPVV FFYLSQDSRP
     RSWCLRTVCN PTARTWFERI SMLVILLNCV TLGMFRPCED IACDSQRCRI LQAFDDFIFA
     FFAVEMVVKM VALGIFGKKC YLGDTWNRLD FFIVIAGMLE YSLDLQNVSF SAVRTVRVLR
     PLRAINRVPS MRILVTLLLD TLPMLGNVLL LCFFVFFIFG IVGVQLWAGL LRNRCFLPEN
     FSLPLSVDLE RYYQTENEDE SPFICSQPRE NGMRSCRSVP TLRGEGGGGP PCGLDYEAYN
     SSSNTTCVNW NQYYTNCSAG EHNPFKGAIN FDNIGYAWIA IFQVITLEGW VDIMYFVMDA
     HSFYNFIYFI LLIIVGSFFM INLCLVVIAT QFSETKQRES QLMREQRVRF LSNASTLASF
     SEPGSCYEEL LKYLVYILRK AARRLAQVSR AAGVRAGLLS SPAPLGGQET QPSSSCSRSH
     RRLSLGNGTL RVPRASPEIQ DRDANGSRRL MLPPPSTPAL SGGPPGGAES VHSFYHADCH
     LEPVRCQAPR PRSPSEASGR TVGSGKVYPT VHTSPPPETL KEKALVEVAA SSGPATLTSL
     NIPPGPYSSM HKLLETQSTG ACQSSCKISS PCLKADSGAS GPDSCPYCAR AGAGEVELAD
     REMPDSDSEA VYEFTQDAQH SDLRDPHSWR PRSLGPDAEP SSVLAFWRLI CDTFRKIVDS
     KYFGRGIMIA ILVNTLSMGI EYHEQPEELT NALEISNIVF TSLFALEMLL KLLVYGPFGY
     IKNPYNIFDG VIVVISVWEI VGQQGGGLSV LRTFRLMRVL KLVRFLPALQ RQLVVLMKTM
     DNVATFCMLL MLFIFIFSIL GMHLFGCKFA SERDGDTLPD RKNFDSLLWA IVTVFQILTQ
     EDWNKVLYNG MASTSSWAAL YFIALMTFGN YVLFNLLVAI LVEGFQAEEI SKREDASGQL
     SCIQLPVDSQ GGDANKSESE PDFFSPSLDG DGDRKKCLAL VSLGEHPELR KSLLPPLIIH
     TAATPMSLPK STSTGLGEAL GPTSRRTSSS GSAEPGAAHE MKSPPSARSS PHSPWSAASS
     WTSRRSSRNS LGRAPSLKRR SPSGERRSLL SGEGQESQDE EESSEEERAS PAGSDRRHRE
     SLEREAKSSF DLPDTLQVPG LHRTASGRGS ASEHQDCNGK SASGRLARAL RPDDPPLDGD
     DADDEGNLSK GERVRAWIRA RLPACCLERD SWSAYIFPPQ SRFRLLCHRI ITHKMFDHVV
     LVIIFLNCIT IAMERPKIDP HSAERIFLTL SNYIFTAVFL AEMTVKVVAL GWCFGEQAYL
     RSSWNVLDGL LVLISVIDIL VSMVSDSGTK ILGMLRVLRL LRTLRPLRVI SRAQGLKLVV
     ETLMSSLKPI GNIVVICCAF FIIFGILGVQ LFKGKFFVCQ GEDTRNITNK SDCAEASYRW
     VRHKYNFDNL GQALMSLFVL ASKDGWVDIM YDGLDAVGVD QQPIMNHNPW MLLYFISFLL
     IVAFFVLNMF VGVVVENFHK CRQHQEEEEA RRREEKRLRR LEKKRRNLML DDVIASGSSA
     SAASEAQCKP YYSDYSRFRL LVHHLCTSHY LDLFITGVIG LNVVTMAMEH YQQPQILDEA
     LKICNYIFTV IFVLESVFKL VAFGFRRFFQ DRWNQLDLAI VLLSIMGITL EEIEVNASLP
     INPTIIRIMR VLRIARVLKL LKMAVGMRAL LDTVMQALPQ VGNLGLLFML LFFIFAALGV
     ELFGDLECDE THPCEGLGRH ATFRNFGMAF LTLFRVSTGD NWNGIMKDTL RDCDQESTCY
     NTVISPIYFV SFVLTAQFVL VNVVIAVLMK HLEESNKEAK EEAELEAELE LEMKTLSPQP
     HSPLGSPFLW PGVEGPDSPD SPKPGALHPA AHARSASHFS LEHPSDRQLF DTISLLIQGS
     LEWELKLMDE LAGPGGQPSA FPSAPSLGGS DPQIPLAEME ALSLTSEIVS EPSCSLALTD
     DSLPDDMHTL LLSAPESNVQ PHPTELPGPD LLTVRKSGVS RTHSLPNDSY MCRHGSIAEG
     PLGHRGWGLP KAQSGSVLSV HSQPADTSYI LQLPKDAPHL LQPYSTPTWG TIPKLPPPGR
     SPLAQRPLRR QFGLSCGAQX VQGLGSREDL LAEVSGPSLP LARAYSFWGQ SSTQAQQHSR
     SHSNISKHMP PRAPCPGPQP NWDKGPPETR SSLELDTELS WISGDLLPPG GQEEPPSPRD
     LKKCYSVEAQ SCQRRPTSWL DEQRRHSIAV SCLDSGSQPH LGTDASNLGG QPLGGPGSRP
     KKKLSPPSIS IDPPESQGPR PPPSPGVCLR RRAPSSDSKD PLASGPPDSM AASPSPKKDV
     LSLSGLSSDP ADLDP
//
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