ID A0A099DAJ9_9ACTN Unreviewed; 419 AA.
AC A0A099DAJ9;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=3-oxoacyl-ACP synthase {ECO:0000313|EMBL:ASU79892.1};
GN ORFNames=CDG81_18305 {ECO:0000313|EMBL:ASU79892.1}, IL38_06620
GN {ECO:0000313|EMBL:KGI82390.1};
OS Actinopolyspora erythraea.
OC Bacteria; Actinomycetota; Actinomycetes; Actinopolysporales;
OC Actinopolysporaceae; Actinopolyspora.
OX NCBI_TaxID=414996 {ECO:0000313|EMBL:ASU79892.1, ECO:0000313|Proteomes:UP000215043};
RN [1] {ECO:0000313|EMBL:KGI82390.1, ECO:0000313|Proteomes:UP000029737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM90600 {ECO:0000313|EMBL:KGI82390.1,
RC ECO:0000313|Proteomes:UP000029737};
RX PubMed=25250723;
RA Chen D., Feng J., Huang L., Zhang Q., Wu J., Zhu X., Duan Y., Xu Z.;
RT "Identification and Characterization of a New Erythromycin Biosynthetic
RT Gene Cluster in Actinopolyspora erythraea YIM90600, a Novel Erythronolide-
RT Producing Halophilic Actinomycete Isolated from Salt Field.";
RL PLoS ONE 9:E108129-E108129(2014).
RN [2] {ECO:0000313|EMBL:ASU79892.1, ECO:0000313|Proteomes:UP000215043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM 90600 {ECO:0000313|EMBL:ASU79892.1,
RC ECO:0000313|Proteomes:UP000215043};
RA Yin M., Tang S.;
RT "The complete genome sequence of moderately halophilic actinomycete
RT Actinopolyspora erythraea YIM 90600, the producer of novel erythromycin,
RT novel actinopolysporins A-C and tubercidin.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP022752; ASU79892.1; -; Genomic_DNA.
DR EMBL; JPMV01000012; KGI82390.1; -; Genomic_DNA.
DR RefSeq; WP_052427867.1; NZ_KN214174.1.
DR AlphaFoldDB; A0A099DAJ9; -.
DR KEGG; aey:CDG81_18305; -.
DR eggNOG; COG0304; Bacteria.
DR HOGENOM; CLU_000022_69_0_11; -.
DR OrthoDB; 9808669at2; -.
DR Proteomes; UP000029737; Unassembled WGS sequence.
DR Proteomes; UP000215043; Chromosome.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProt.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 1..413
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 419 AA; 43219 MW; 7DE9F3BD882DBD41 CRC64;
MTTSTPVPLD RANSTRRVVV TGLGVVSSIG SGREAYLAGL REGRCGTGPI SLFDTTGFRH
GNGCEVTDFD PAEVLRTVRA EEFGRVGRFS AAAARMAATD AGLPEGPTGS GLVAVGTTDG
ESLDLDELAA SFSGYGSSDG AESTRAGRIR PARLSTAVAR ELGLSDVEVA TMPTVCAAGN
YTLGYGLDAL RAGDVDFALC GGAESVCRRT FASFYRMGAL SPDLCRPFDR DRAGVVFGEG
AAVLVLESLE SASARGARVL AEMLEYHLNC DAMHPTRPDE DSVTACVAGA VRNAGISPAE
VDLVLAHGTG TPINDSLESR AFGRVFGFDG IPPVSAPKSM IGHTMGAAAS HSCTAAVLAL
EHGFLPPTVN HGTTDPDCPV DCVPNHSRAA DPRTILVNSL GFGGGNAAMV LRRWEGGEP
//
