ID A0A099NZK3_PICKU Unreviewed; 1197 AA.
AC A0A099NZK3;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=JL09_g2710 {ECO:0000313|EMBL:KGK38080.1};
OS Pichia kudriavzevii (Yeast) (Issatchenkia orientalis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=4909 {ECO:0000313|EMBL:KGK38080.1, ECO:0000313|Proteomes:UP000029867};
RN [1] {ECO:0000313|Proteomes:UP000029867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SD108 {ECO:0000313|Proteomes:UP000029867};
RX PubMed=25159171; DOI=10.1186/s12934-014-0121-4;
RA Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT "Exploiting Issatchenkia orientalis SD108 for succinic acid production.";
RL Microb. Cell Fact. 13:121-121(2014).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGK38080.1}.
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DR EMBL; JQFK01000024; KGK38080.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A099NZK3; -.
DR VEuPathDB; FungiDB:C5L36_0B10540; -.
DR eggNOG; KOG0217; Eukaryota.
DR HOGENOM; CLU_002472_1_0_1; -.
DR Proteomes; UP000029867; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677}.
FT DOMAIN 1030..1046
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..182
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1197 AA; 136526 MW; 6851E7FBEC31ADFF CRC64;
MVEEIPKKMK QASLMSFLTR KKPIVKPPTP PAEESNKPPL KELQPPIETT ITPDTTVDDF
KGSQELGLNL REENSNVKKK ETPSKLQKEH YRDPTSSPAH LNGSFDDSFN SIASSPVKGR
RKRINYSELS DEDEDEEDGV VKPRKKKRSF AWDDGDDEDF DMDSDVKNSD NDDDDDDEFT
DDRNSTKEEL ENLYDNTKIE SEEEIEKDDF VEPLRKTSNS SKKGSKISSI LSGRQKSPLK
SNSLSAQKKF SKENEERYQW LITVKDADGH LETDPNYDPR TLYIPPSAWA KFTAFEKQYW
EIKSKMWDTV VFFKKGKFFE LYEKDADIAH SKFDLKLAGT GRANMRLAGV PEMSFDYWAK
RFITAGYKVA KVDQKESMLA KEIRGKNGAQ DAKESKVIQR ELEYVLTCGT LMDENLLNDE
MSKYCLSIKE NIDWENSSKK IGLCFVDVST GNFYLLEFDD DLECSKLETL LSQINPMEVL
VPKNELDTLT LRVLKFNSHP NASFNFIKPE AEFWDHEKTV DELSKFNETH DLKTPPVLQS
YYQHDKFLAF SAFGAVFWYL RTLKLDSNII SMGNFKEYNP FDKNLLGSSM RLDGITLQNL
EVFNNSFDQS DRGTLFRILN RGVTAFGKRV FKNWVIHPLL NKHAIDERLD SVELLLNDGD
LKYIIESKLK RVVDIERMLT RIHSKSLRAK DFVKVIDSFQ VISELVNDIN RYGIENLRGL
LRSLINSFPI AEMNDLLVTW NDKFDRDAAI NEDLIVPKEG VDAEFDESNV KIIGVENELN
AYLKEYRKQY KSNEICYKDS GKEIYLIEVP IKLANKIPRD WQQMAATSKC KRYWSPEVKS
LVKKLMELRE LHKIICLNLK DKIYENFDKS YEKCMKVVTS IGKIDCLISL TRASESLGYP
ICRPEIVESD NSFIDYKQLR HPCFMPGSGI LTTKDFIPND IELGIDNKNN IGLLTGANAA
GKSTLLRMSC IATIMAQIGC FLPAESARLS PVDAIMTRLG ANDNIMQGKS TFYVELLETK
KMLDNATPKS LIILDELGRG GSSSDGFAIA EAVLHHFATH IQAIGFFATH YANLGQSFLN
HPKIIPLRMA ILVDSDSKKI TFLYKLEKGQ SNGSFGMHVA TMCGIPKEIV QNAEIAAKKW
EHTSKLDKIN DTKAGVIPLG VESDFSWWSQ NKHIVSCFGQ EVEKEAMRSI FTMIDGL
//
