ID A0A099P1D2_PICKU Unreviewed; 986 AA.
AC A0A099P1D2;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA repair protein RAD4 {ECO:0008006|Google:ProtNLM};
GN ORFNames=JL09_g2150 {ECO:0000313|EMBL:KGK38725.1};
OS Pichia kudriavzevii (Yeast) (Issatchenkia orientalis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=4909 {ECO:0000313|EMBL:KGK38725.1, ECO:0000313|Proteomes:UP000029867};
RN [1] {ECO:0000313|Proteomes:UP000029867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SD108 {ECO:0000313|Proteomes:UP000029867};
RX PubMed=25159171; DOI=10.1186/s12934-014-0121-4;
RA Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT "Exploiting Issatchenkia orientalis SD108 for succinic acid production.";
RL Microb. Cell Fact. 13:121-121(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGK38725.1}.
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DR EMBL; JQFK01000016; KGK38725.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A099P1D2; -.
DR VEuPathDB; FungiDB:C5L36_0A04250; -.
DR eggNOG; KOG2179; Eukaryota.
DR HOGENOM; CLU_003639_1_2_1; -.
DR Proteomes; UP000029867; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.60.290; Rad4, beta-hairpin domain BHD2; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF3; DNA REPAIR PROTEIN RAD4; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 521..582
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 584..654
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 661..736
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 16..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..148
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..639
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..939
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..960
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 986 AA; 113393 MW; 8687080E77DA19F0 CRC64;
MSVPSQYKDL LRNALQQERT NKWTNGSTQA PLKSPKRRRI LSPVERMREL KKKKETDGEP
KDERYVIHIN DEDNDDISMK RSFEGQKSER PDPLSGKHDE DNKEGFSDTG DLDKSEEDEE
IDSDEFEDVD LDGTSFMDDA DGDESENEEI NITIQKNAHN KRATKGSVIS SEERIFRRKL
HLMHLFVMVG HGVTRNAWLS DPKFLLNLQK QIPLKLKKEL QEYQQHRQKS NVTAQSKTRR
LLDLLRHLME YWQRVWKIDS RAPVLYKKLW PEIKNQRILP NMKKQRLSKE NFHASILSHV
GSRDISAQGF VALLRSLNLQ ARLVFSIQPP DFTNMKKCED KSEDKDSMPR EASKWSPRKT
SKPANVKENL LSALRSRKAY TNTVTKTQAQ HREEFAEKFG GWPVFWAEVW DKDSKKYITI
DPIVKKLIEV VSWKSKLEPP MNSIRNNAWY VVGYDRVGGI RDVTRRYAKE YNAKVRKKRI
TRDPKWELWW ASLLRGACSK KRLNDNRVDK FEQIEFEELS LKEGMPSNVG DFKGHPVYVL
ESDLKYNEIL YPKISCGGLS NKGKSKKASN GFIPVYKRKN VHIVRSARGW FMKGRVLKMG
ERPMKIRKKG TNTNTRKKGR EDDFRLSDSD TGNGDNDDDT RLYAEFQTEK YVPPPVIDGK
IPRNAYKNID IYEPWMVPEG CVHIRNPYAE KAARLMGIEY VPAVVGFDFK SHREVNTKIQ
GVVTFDEFKD AVELVCEGLK EVEEEDNKIR EDIINLRAWK VLLTRLKINR RLIAEHGEVE
DDDEDAYKVN DNDSGEDVSN DDSNGIGGGG FLYNSSITLP ASSRTRSHYQ HEDMPIYERS
DLSASDFEDE VADENNIQYK NIPLALQRKG KLRKAAAKPK SGETPSSPVD APVGTLSVAE
GGMLNEKDDL VYNPEGSDGY NGGEDSDSSE EEVDEDDERM KELDKDMDFG DLEDVHVEND
SAEANSSGDN RTAPTPNDDY EFEFSE
//
