ID A0A099P267_PICKU Unreviewed; 500 AA.
AC A0A099P267;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Succinate-semialdehyde dehydrogenase, mitochondrial {ECO:0000256|ARBA:ARBA00019842};
DE EC=1.2.1.24 {ECO:0000256|ARBA:ARBA00013051};
DE AltName: Full=NAD(+)-dependent succinic semialdehyde dehydrogenase {ECO:0000256|ARBA:ARBA00030806};
GN ORFNames=C5L36_0B12100 {ECO:0000313|EMBL:AWU75980.1}, JL09_g1826
GN {ECO:0000313|EMBL:KGK38995.1};
OS Pichia kudriavzevii (Yeast) (Issatchenkia orientalis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=4909 {ECO:0000313|EMBL:KGK38995.1, ECO:0000313|Proteomes:UP000029867};
RN [1] {ECO:0000313|Proteomes:UP000029867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SD108 {ECO:0000313|Proteomes:UP000029867};
RX PubMed=25159171; DOI=10.1186/s12934-014-0121-4;
RA Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT "Exploiting Issatchenkia orientalis SD108 for succinic acid production.";
RL Microb. Cell Fact. 13:121-121(2014).
RN [2] {ECO:0000313|EMBL:KGK38995.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SD108 {ECO:0000313|EMBL:KGK38995.1};
RA Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT "Exploiting Issatchenkia orientalis SD108 for Succinic Acid Production.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AWU75980.1, ECO:0000313|Proteomes:UP000249293}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS573 {ECO:0000313|EMBL:AWU75980.1,
RC ECO:0000313|Proteomes:UP000249293};
RA Douglass A.P., Offei B., Braun-Galleani S., Coughlan A.Y., Martos A.,
RA Ortiz-Merino R.A., Byrne K.P., Wolfe K.H.;
RT "Population genomics shows no distinction between pathogenic Candida krusei
RT and environmental Pichia kudriavzevii: One species, four names.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
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DR EMBL; CP028774; AWU75980.1; -; Genomic_DNA.
DR EMBL; JQFK01000013; KGK38995.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A099P267; -.
DR STRING; 4909.A0A099P267; -.
DR VEuPathDB; FungiDB:C5L36_0B12100; -.
DR eggNOG; KOG2451; Eukaryota.
DR HOGENOM; CLU_005391_0_2_1; -.
DR OrthoDB; 216092at2759; -.
DR Proteomes; UP000029867; Unassembled WGS sequence.
DR Proteomes; UP000249293; Chromosome 2.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07103; ALDH_F5_SSADH_GabD; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR43353; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43353:SF5; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000249293}.
FT DOMAIN 32..495
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 271
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 500 AA; 54199 MW; F8C77B5FFDE8AC59 CRC64;
MSSSTEIKAF ADKYGIKNVN LIRTGALVNG EWVYNTDDVF SVTDPGTGDH LLHVSNTKIE
VIEQGIKDAQ TAFESYLSKS TGRERGRILR KFYDLMLENF NDLAILCTIE NGKSLTDSKG
EITYASSFFE WFAEEAPRIY ADNIPSAASN KRIITSKQPI GVVGILTPWN FPAAMITRKL
GAAFAAGCST VIKPATETPL SALALGYLAE EAGFPKGMLS MFPVDQKRTI QVGKLFCESP
IVKKISFTGS TGVGKLLMQQ SSSTLKKLSF ELGGNAPFIV FEDADVDAAV QGAIGCKLRQ
SGQTCICANR LYIHEEVYEE FAAKFVAEVS KTVLGHGLEP DTTHGPLIHE RAVAKVQEHI
QDAVSKGAKV LYGGNRASHL GENFHELTVL GDVPKSARVN KEETFGPVVP LIRFSSEEEV
LQLANDTEYG LAGYFFSRDY ARIFRFGEKL QCGMVGANTG ALGEAALPFG GIGWSGFGRE
GSKYGIDDYT VLKSIVIGGI
//
