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Database: UniProt
Entry: A0A099P2Y7_PICKU
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ID   A0A099P2Y7_PICKU        Unreviewed;       340 AA.
AC   A0A099P2Y7;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=2-dehydropantoate 2-reductase {ECO:0000256|RuleBase:RU362068};
DE            EC=1.1.1.169 {ECO:0000256|RuleBase:RU362068};
DE   AltName: Full=Ketopantoate reductase {ECO:0000256|RuleBase:RU362068};
GN   ORFNames=BOH78_0415 {ECO:0000313|EMBL:ONH77364.1}, C5L36_0B09130
GN   {ECO:0000313|EMBL:AWU75672.1}, JL09_g1428
GN   {ECO:0000313|EMBL:KGK39373.1};
OS   Pichia kudriavzevii (Yeast) (Issatchenkia orientalis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Pichia.
OX   NCBI_TaxID=4909 {ECO:0000313|EMBL:KGK39373.1, ECO:0000313|Proteomes:UP000029867};
RN   [1] {ECO:0000313|Proteomes:UP000029867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SD108 {ECO:0000313|Proteomes:UP000029867};
RX   PubMed=25159171; DOI=10.1186/s12934-014-0121-4;
RA   Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT   "Exploiting Issatchenkia orientalis SD108 for succinic acid production.";
RL   Microb. Cell Fact. 13:121-121(2014).
RN   [2] {ECO:0000313|EMBL:KGK39373.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SD108 {ECO:0000313|EMBL:KGK39373.1};
RA   Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT   "Exploiting Issatchenkia orientalis SD108 for Succinic Acid Production.";
RL   Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000189274}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=129 {ECO:0000313|Proteomes:UP000189274};
RX   PubMed=28385833; DOI=10.1128/genomeA.00064-17;
RA   van Rijswijck I.M.H., Derks M.F.L., Abee T., de Ridder D., Smid E.J.;
RT   "Genome sequences of Cyberlindnera fabianii 65, Pichia kudriavzevii 129,
RT   and Saccharomyces cerevisiae 131 isolated from fermented masau fruits in
RT   Zimbabwe.";
RL   Genome Announc. 5:E00064-E00064(2017).
RN   [4] {ECO:0000313|EMBL:ONH77364.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=129 {ECO:0000313|EMBL:ONH77364.1};
RA   Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:AWU75672.1, ECO:0000313|Proteomes:UP000249293}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS573 {ECO:0000313|EMBL:AWU75672.1,
RC   ECO:0000313|Proteomes:UP000249293};
RA   Douglass A.P., Offei B., Braun-Galleani S., Coughlan A.Y., Martos A.,
RA   Ortiz-Merino R.A., Byrne K.P., Wolfe K.H.;
RT   "Population genomics shows no distinction between pathogenic Candida krusei
RT   and environmental Pichia kudriavzevii: One species, four names.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the NADPH-dependent reduction of ketopantoate into
CC       pantoic acid. {ECO:0000256|RuleBase:RU362068}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH;
CC         Xref=Rhea:RHEA:16233, ChEBI:CHEBI:11561, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15980, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC         EC=1.1.1.169; Evidence={ECO:0000256|RuleBase:RU362068};
CC   -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC       {ECO:0000256|ARBA:ARBA00007870, ECO:0000256|RuleBase:RU362068}.
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DR   EMBL; CP028774; AWU75672.1; -; Genomic_DNA.
DR   EMBL; JQFK01000009; KGK39373.1; -; Genomic_DNA.
DR   EMBL; MQVM01000002; ONH77364.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A099P2Y7; -.
DR   VEuPathDB; FungiDB:C5L36_0B09130; -.
DR   eggNOG; ENOG502QWBM; Eukaryota.
DR   HOGENOM; CLU_031468_2_1_1; -.
DR   OrthoDB; 1816688at2759; -.
DR   Proteomes; UP000029867; Unassembled WGS sequence.
DR   Proteomes; UP000189274; Unassembled WGS sequence.
DR   Proteomes; UP000249293; Chromosome 2.
DR   GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015940; P:pantothenate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR003710; ApbA.
DR   InterPro; IPR013752; KPA_reductase.
DR   InterPro; IPR013332; KPR_N.
DR   NCBIfam; TIGR00745; apbA_panE; 1.
DR   PANTHER; PTHR21708:SF30; 2-REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00740)-RELATED; 1.
DR   PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR   Pfam; PF02558; ApbA; 1.
DR   Pfam; PF08546; ApbA_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|RuleBase:RU362068};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU362068};
KW   Reference proteome {ECO:0000313|Proteomes:UP000249293}.
FT   DOMAIN          7..161
FT                   /note="Ketopantoate reductase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02558"
FT   DOMAIN          194..316
FT                   /note="Ketopantoate reductase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08546"
SQ   SEQUENCE   340 AA;  37760 MW;  BA09E5610B9C272C CRC64;
     MTITPNILLV GPGGVGAIVA YGLQYTGKAV LSVVVRGDYE KVSKDGFEIK SPHYGHVKSW
     KPVNVYPTID AAAKNSKFYD YVVISTKNLP DITKLEDMVE PVITPAKTTI VLVQNGFGID
     RPFISKYPKN ICLSGISHIG SSILHGVVTQ KTRDENHIGY FLNENLPVKV QEEKAKQFID
     IYSNEHNTII YCENVKAFRY QKLVYNACFN TICALTGLDT SRLYLSGSYN TLLVPAMREV
     VSVAKADGIT LRDDVIDYYA HISDGHYYKP SMQIDVEKGN PIEVETILGN LIKVADSLQV
     PIPTLKMLYS LLHAVQFRLK EGRGIVSVPE SAPVNNEHYS
//
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