ID A0A099P4F3_PICKU Unreviewed; 550 AA.
AC A0A099P4F3;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN ORFNames=JL09_g1624 {ECO:0000313|EMBL:KGK39174.1};
OS Pichia kudriavzevii (Yeast) (Issatchenkia orientalis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=4909 {ECO:0000313|EMBL:KGK39174.1, ECO:0000313|Proteomes:UP000029867};
RN [1] {ECO:0000313|Proteomes:UP000029867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SD108 {ECO:0000313|Proteomes:UP000029867};
RX PubMed=25159171; DOI=10.1186/s12934-014-0121-4;
RA Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT "Exploiting Issatchenkia orientalis SD108 for succinic acid production.";
RL Microb. Cell Fact. 13:121-121(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGK39174.1}.
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DR EMBL; JQFK01000011; KGK39174.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A099P4F3; -.
DR VEuPathDB; FungiDB:C5L36_0A02540; -.
DR eggNOG; KOG2214; Eukaryota.
DR HOGENOM; CLU_009031_5_0_1; -.
DR Proteomes; UP000029867; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR PANTHER; PTHR14226:SF44; TRIACYLGLYCEROL LIPASE 3; 1.
DR Pfam; PF11815; DUF3336; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 22..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 199..394
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
SQ SEQUENCE 550 AA; 63610 MW; 13F90E763CEF7BA8 CRC64;
MLIIHKYSSI HGSTVENFLF SVIIWILTHI PLPILKLILL LFDVFVYWFG SIYDKFKNSP
DRILLYKLNH STSWSEFSKT AFDLDNYFNN DIWKNNLVSS KYDYVLIQER LHDLRNARLS
NNFQHMLSLL RAGMLRNLGG ISNKSLYNRT YIGTKSLIEQ YNKEVANCLE SLDKDPFIDN
QLKLDFYHDA KTTLGATALC LHGGSLFGMG HIGVVKSLLD QNLLPNVLVG SGVGSVVGAL
VGCLEKEELV EILVNLKNVM QEEGYGLKPK NCNDPIESTQ IGLKWIENIK KGVTKEMKLF
IDFVLSKVGG MTFKQAHEKT GKTFNILVYP KSSKLPTLLN YLSTPYITME SAIRCSLGTG
ELKDKIPTLE IKFRGDITKY SNVQCDFQPP YQVRGQSIEL KNSPYNRITE MFNVNHFVIS
ISRPYLASFV SMRWRRIYNY NSLLKKLLNI INIELKHRIR MLNRFGLLNT PLRWLLVDEK
SVLVDTNHIA IIPTGTRWIL WDFIDLFVQN KSVMNYWIEC GERSVWSMHS LLETRSRAEF
LLDEYFQKYR
//
