ID A0A099P573_PICKU Unreviewed; 1616 AA.
AC A0A099P573;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Thioredoxin domain-containing protein {ECO:0000259|PROSITE:PS51352};
GN ORFNames=JL09_g1458 {ECO:0000313|EMBL:KGK39362.1};
OS Pichia kudriavzevii (Yeast) (Issatchenkia orientalis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=4909 {ECO:0000313|EMBL:KGK39362.1, ECO:0000313|Proteomes:UP000029867};
RN [1] {ECO:0000313|Proteomes:UP000029867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SD108 {ECO:0000313|Proteomes:UP000029867};
RX PubMed=25159171; DOI=10.1186/s12934-014-0121-4;
RA Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT "Exploiting Issatchenkia orientalis SD108 for succinic acid production.";
RL Microb. Cell Fact. 13:121-121(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGK39362.1}.
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DR EMBL; JQFK01000009; KGK39362.1; -; Genomic_DNA.
DR VEuPathDB; FungiDB:C5L36_0B09460; -.
DR VEuPathDB; FungiDB:C5L36_0B09470; -.
DR VEuPathDB; FungiDB:C5L36_0B09480; -.
DR eggNOG; KOG0191; Eukaryota.
DR eggNOG; KOG0764; Eukaryota.
DR eggNOG; KOG4476; Eukaryota.
DR HOGENOM; CLU_243709_0_0_1; -.
DR Proteomes; UP000029867; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0006862; P:nucleotide transport; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd02961; PDI_a_family; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR018608; Gti1/Pac2.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR044712; SLC25A32-like.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR45683:SF2; MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED; 1.
DR PANTHER; PTHR45683; MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED; 1.
DR Pfam; PF09729; Gti1_Pac2; 2.
DR Pfam; PF00153; Mito_carr; 3.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50920; SOLCAR; 3.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 603..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 668..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..728
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 778..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1566..1587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 599..697
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 704..806
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 829..921
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT DOMAIN 899..1045
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REGION 110..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1616 AA; 184721 MW; 3332A0BAC52BD48D CRC64;
MVMRNKTPVS ATYHGYIASS RDALLVIDAV LRGLLLPVTN RPTPKERKAL IRSGNVFVFI
EEESNIKRWT DGTSWSPSRI LGRFLIYREL SKNIVKDSNN NLSAITSVVE DNGDSNNMDN
GNASGSRATS TATNNNNNNN NSSTNNNGAN NHYASTESRF VKLNCQPITA YAMAGGEDVI
RKRSIDDVIK EDANSNNNNN NNNNTDTNST HNSIRGDTTI SNTNEINTNL LNSNIEVDVL
SDNIYRSDGL IKKSLSIVLH SPSRKTIHLV SYYTTKDVIN DKLNIPSSDN FFKDNSVVPS
YELIDSLLNT SLGHSISHRR RSDPSSGPIS FLDTDGFDDQ TVMSYTNHKR RRLSEQRQQQ
QQQQQQQQQQ LQQLQQQQQQ QQQHNKINNN NNNNSSSSIN IINRFRCNCL NNFTLLTHTP
RTSYDEHAVP SMPVLRSASH PGFDTLPLSH DFQQPQQTAS VTQTHQYHQH HPQQQQQQQQ
LATAAPPLSQ QLDYPTSLRT LPVSQSSQMQ QNDQLQFNAS PLVNETDDIS NQNKHPQSTL
ESSNLLTLSS EDSIHSHGCD CEPPKTHQIS TDISVHAVPV LEPLSTHKND LRAFKLRLSP
NEITSISGAL AGFISGLVVC PLDVAKTRFQ AQGAYNNSND IDKKKILPIL MSAVQSIKLI
WKEEGFRGLY RGVVPITLGY FPTWMIYFTC YEHFKKFYNN YIHDDNLSYF ASAISSGAIS
TTLTNPIWVV KTRLMLQMDD GKTVYSSSNV NANTSTNVTR NGDFDAFKKM YQHEGLNVFY
RGLLPSYFGL IHVAIQFPLY ENFKKILKIS NNGDETLDMS NTSTKMKTLN FLKFILASSL
SKMIASAITY PHEILRTRLQ LFNNNSNQQN ESQLKGLKRV FKNIIKVEGF KGFYSGFIIN
LARTVPASAV TMVSFEYFRE YFQSANENES SNDLQSRVPP PLTLSNFDNT LLKGFHMVEF
YSPYCHHCQN LFPTWVEFYE SNPESSGYAI HQVDCVVSGD LCDREGIRYF PMIRFYGPNS
KLLASMTSSS RTIDTLNEFA NEQLLIWNEE GDSKFNEDDF VGLQNSMIDN SELRKVLSGD
LEVPKLISFW PTSNDQLNDS NFQNKYNAHA IFKNSENLYN FRNIWNFVIR NLHKFGEEHK
LEFHYVNCKS NAALCGSLGF SELLNSNLKN LTPRIVLYLP KSNGNSLFLK PSLIKNRKFN
HIVKFITNWT YRNLINSELQ DLKINDIKNF IGATTKLKDK NDISDIPNYS KVAFIQVNDP
NTQVLEDDII LDHLLQPVAD LDSEVYLFKS TDKDGALKLL QDQERNLIDY IKIDEQSLQD
KISEKLFISR TRSTFPMFIA LKSSSLYTPV YQSFTSKEIR DTKKVLSFIR SNYLPMINHL
SDDNKYQVFP KRMSPLNSKT EKILVSITDF QPKQFFEVEF YMSKVYHKFQ YLRNMKIFQK
IDKQRNEKHE EVNRMKLNDA TSDDIIDKLR EKITESYIST DNNLFPVYLD LDTLSKVASS
LNWNKLDIQK YKVGDSILIS RFTGQYWDQD LRGRQLNIEN IDETVNLLKD ILKNKNSGKS
ITRQSILLTI FQVWILLLVI AACLHYYKRF QIKRAQQNEK MKGLGILGLS ADSKFD
//
