ID   A0A099P5C2_PICKU        Unreviewed;       899 AA.
AC   A0A099P5C2;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=phosphatidylserine decarboxylase {ECO:0000256|ARBA:ARBA00012243};
DE            EC=4.1.1.65 {ECO:0000256|ARBA:ARBA00012243};
GN   ORFNames=JL09_g818 {ECO:0000313|EMBL:KGK40145.1};
OS   Pichia kudriavzevii (Yeast) (Issatchenkia orientalis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Pichia.
OX   NCBI_TaxID=4909 {ECO:0000313|EMBL:KGK40145.1, ECO:0000313|Proteomes:UP000029867};
RN   [1] {ECO:0000313|Proteomes:UP000029867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SD108 {ECO:0000313|Proteomes:UP000029867};
RX   PubMed=25159171; DOI=10.1186/s12934-014-0121-4;
RA   Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT   "Exploiting Issatchenkia orientalis SD108 for succinic acid production.";
RL   Microb. Cell Fact. 13:121-121(2014).
CC   -!- COFACTOR:
CC       Name=pyruvate; Xref=ChEBI:CHEBI:15361;
CC         Evidence={ECO:0000256|ARBA:ARBA00001928};
CC   -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC       biosynthesis. {ECO:0000256|ARBA:ARBA00024326}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KGK40145.1}.
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DR   EMBL; JQFK01000004; KGK40145.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A099P5C2; -.
DR   VEuPathDB; FungiDB:C5L36_0E01370; -.
DR   eggNOG; KOG2419; Eukaryota.
DR   HOGENOM; CLU_322119_0_0_1; -.
DR   UniPathway; UPA00558; -.
DR   Proteomes; UP000029867; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004609; F:phosphatidylserine decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR003817; PS_Dcarbxylase.
DR   InterPro; IPR033177; PSD-B.
DR   NCBIfam; TIGR00163; PS_decarb; 1.
DR   PANTHER; PTHR10067; PHOSPHATIDYLSERINE DECARBOXYLASE; 1.
DR   PANTHER; PTHR10067:SF17; PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF02666; PS_Dcarbxylase; 1.
DR   SMART; SM00239; C2; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   PROSITE; PS50004; C2; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW   Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW   Pyruvate {ECO:0000256|ARBA:ARBA00023317};
KW   Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   DOMAIN          221..349
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
SQ   SEQUENCE   899 AA;  101616 MW;  E63C22F9FA79370E CRC64;
     MDHATQQVFN NQLVSSGVKI PIVFSVQERL ENGTLGDCRI KDVSILKDHL TSSIIFDISK
     NRLSEYTVKF EVSICNLASI QRLQLNNDSI KAVVYLENEK TSSILETISL KNLLELGSKK
     VSHFTKTLNE FHLDLNFSID SSDKRTEEEI TNHFTTLRLP YSPQSDLTSL PSYFSSDISS
     TNQSFASLNS LSPPSRPNST CSKKKSIPNF LKPSLKGSSK TNSNIDISTS NPDLYHEDTD
     GFLILQIESA TGLPPFKKKT QLGYDMDPFV VVSFSKQIYK TNVCRHALNP SWKNQLINIR
     VSKYSLKFLL KLSVYDFDVF TFNDDICSTS LEIGDLINES EHNSNDTWTY KKLPLSFSDR
     ALSKKLLKTQ NYMPELSIRF KYVPVSTLAG LVHSFNPTKT RCPYCHKLDK KHASALQHLS
     ICRMGLKPSQ FLHKHYTTSN HASRRWYVKI LAHIAYGRLT VGGNNAHILV QDRVTGLVLE
     EKISVFVKLG IRLLYKSVKS DNSSEKIKKM LRSLSIKQGA KYDKPSSKSK IEEFVKFHGL
     KSTLVECENP DLSSYRTFNE FFSRKLKSDA RPLEGGTDNQ IIVSVADSRL IVFNDISSAK
     NLWIKGNGFT VDKLLGRKET GEVKFKYSIA IFRLAPQDYH RVHLPLNGKI VKINHIHGSY
     YTVNPMAIRS ALDVFGENVR TVITLETEEY GDVELVMVGA MMVGSIILSV KVNDIVKKGQ
     ELGYFKFGGS TVILVFRNSR EDSNMPKMVW DGDLLSNSNK KLETLVKVGM SVGHSVRSKE
     FRRGVKKEVS DSERREIIRR VTGIPENPTP GVGDNIKAKL GGMIDDVMST KSVKSYNQRN
     EIENMLQSDW EIKELTTLEG LNDNGELRDQ IDIDVTRGFD GTNFFHMLDD SDEYNSLDK
//