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Database: UniProt
Entry: A0A099S1A6_9CLOT
LinkDB: A0A099S1A6_9CLOT
Original site: A0A099S1A6_9CLOT 
ID   A0A099S1A6_9CLOT        Unreviewed;       451 AA.
AC   A0A099S1A6;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   05-JUL-2017, entry version 23.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=DP68_12640 {ECO:0000313|EMBL:KGK86780.1};
OS   Clostridium sp. HMP27.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1487921 {ECO:0000313|EMBL:KGK86780.1, ECO:0000313|Proteomes:UP000030009};
RN   [1] {ECO:0000313|EMBL:KGK86780.1, ECO:0000313|Proteomes:UP000030009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HMP27 {ECO:0000313|EMBL:KGK86780.1,
RC   ECO:0000313|Proteomes:UP000030009};
RA   Tan B.F., Foght J., Budwill K.;
RT   "Draft genome sequence of Clostridium sp. HMP27 isolated from a coal
RT   degrading methanogenic culture.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KGK86780.1}.
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DR   EMBL; JMFY01000024; KGK86780.1; -; Genomic_DNA.
DR   RefSeq; WP_035310076.1; NZ_JMFY01000024.1.
DR   EnsemblBacteria; KGK86780; KGK86780; DP68_12640.
DR   Proteomes; UP000030009; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030009};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030009}.
FT   DOMAIN      146    274       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      358    427       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     154    161       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   451 AA;  51301 MW;  CDA73FD8CBC2D2F3 CRC64;
     MNAQLKDIWE NALTIIKGEL TEVSFNTWIK SIVPLKIEAD CFYLCVPNDF TKGILSSRYK
     DLIINALKLI TSKRYNVEFI VSTEEVIDLE KSPSNNIPEK NNNIVVNDEM SAMLNPKYTF
     KSFVIGNSNR FAHAASLAVA EAPAKAYNPL FIYGGVGLGK THLMHAIGHY ILNNNPNSKV
     VYVSSEKFTN ELINSIKDDR NVEFRNKYRN IDVLLIDDVQ FIAGKERTQE EFFHTFNDLH
     ESNKQIILSS DRPPKEIPTL EDRLRSRFEW GLIADIQAPD FETRMAILKK KADVENLSIP
     NEVLVYIATK IKSNIRELEG ALIRIVAFSS LTNKEISVDL ASEALKDIIS NKHSKQVTIE
     SIQDIVSSYF NLRVEDFKSA RRTRNVAFPR QIAMYLCRKL TDTSLPKIGE EFGGRDHTTV
     IHAYEKISSS LKEDESLQNA VSELTKKITQ K
//
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