ID A0A099TP77_9HELI Unreviewed; 606 AA.
AC A0A099TP77;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=UDP-N-acetylglucosamine 4,6-dehydratase (Configuration-retaining) {ECO:0000313|EMBL:TLD79882.1};
GN ORFNames=LS70_009505 {ECO:0000313|EMBL:TLD79882.1};
OS Helicobacter sp. MIT 11-5569.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1548151 {ECO:0000313|EMBL:TLD79882.1, ECO:0000313|Proteomes:UP000029923};
RN [1] {ECO:0000313|EMBL:TLD79882.1, ECO:0000313|Proteomes:UP000029923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 11-5569 {ECO:0000313|EMBL:TLD79882.1,
RC ECO:0000313|Proteomes:UP000029923};
RX PubMed=25428971;
RA Sheh A., Shen Z., Fox J.G.;
RT "Draft genome sequences of eight enterohepatic helicobacter species
RT isolated from both laboratory and wild rodents.";
RL Genome Announc. 2:e01218-e01214(2014).
CC -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC {ECO:0000256|ARBA:ARBA00007430}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TLD79882.1}.
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DR EMBL; JRPB02000019; TLD79882.1; -; Genomic_DNA.
DR RefSeq; WP_034287344.1; NZ_JRPB02000019.1.
DR AlphaFoldDB; A0A099TP77; -.
DR STRING; 1548151.LS70_01600; -.
DR eggNOG; COG1086; Bacteria.
DR OrthoDB; 9769113at2; -.
DR Proteomes; UP000029923; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003869; Polysac_CapD-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR Pfam; PF02719; Polysacc_synt_2; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 280..564
FT /note="Polysaccharide biosynthesis protein CapD-like"
FT /evidence="ECO:0000259|Pfam:PF02719"
SQ SEQUENCE 606 AA; 67297 MW; 960EB11DAFBB820B CRC64;
MLKSVLFRPS NAKRITFFVI IDIIVSYFTL ILSYDLRFSF QVPLEFKANV VLVFFVLIAL
KILALAVFKL YLVPWRFFGL LEALKLFYAH ILAYGIFCGI AFLGVFGSFP LSVVGIDFVI
SSILIGAIRI AKRIYLENSP KNSPKPALIF GANTQAPTLI KAALNSEIPF YPLAIIAEDN
EAVGSYISNL KVYPKSALKE LIAKHKIKSA ILTRAYAKPP LKDLFDALRE LGIEEIKIAT
MLKDNAQEDL QDISIEDLLS RPSKDLDKET IGAFLRDKCV LITGAGGSIG SEIVRQCAEF
GAKRLVLVEH SEFNLYAILE ELNQKYPQKK MDNSALFRPC LLSILEKERL LALIQEEKPD
IIVHAAAYKH VPLCEYNQKS AIENNIIGSK NVVDCAIEAG VPKIVMISTD KAVRPTNVMG
ATKRVVELYA QNVESKNSEI VAVRFGNVLG SSGSVVPKFK AQIQSGGPIT VTHPDITRYF
MLIPEACQLV LQAGAIAKGG EIFILDMGEP VKIVDLAKNM LRLYDKEHEI VIEFSGLRPG
EKLYEELLIG ESEGKTKYPS IQVACPTHYA INKLNEDIAE LIECKDSKSR LEKLKEIVVE
FNHNAG
//
