ID A0A099TWC4_9HELI Unreviewed; 365 AA.
AC A0A099TWC4;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=NAD(P)-dependent alcohol dehydrogenase {ECO:0000313|EMBL:TLE00181.1};
DE SubName: Full=NADP-dependent alcohol dehydrogenase {ECO:0000313|EMBL:STQ87008.1};
DE EC=1.1.1.2 {ECO:0000313|EMBL:STQ87008.1};
GN Name=cad {ECO:0000313|EMBL:STQ87008.1};
GN ORFNames=LS73_005725 {ECO:0000313|EMBL:TLE00181.1}, NCTC12714_01819
GN {ECO:0000313|EMBL:STQ87008.1};
OS Helicobacter muridarum.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=216 {ECO:0000313|EMBL:STQ87008.1, ECO:0000313|Proteomes:UP000255139};
RN [1] {ECO:0000313|EMBL:TLE00181.1, ECO:0000313|Proteomes:UP000029922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST1 {ECO:0000313|EMBL:TLE00181.1,
RC ECO:0000313|Proteomes:UP000029922};
RX PubMed=25428971;
RA Sheh A., Shen Z., Fox J.G.;
RT "Draft genome sequences of eight enterohepatic helicobacter species
RT isolated from both laboratory and wild rodents.";
RL Genome Announc. 2:e01218-e01214(2014).
RN [2] {ECO:0000313|EMBL:STQ87008.1, ECO:0000313|Proteomes:UP000255139}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12714 {ECO:0000313|EMBL:STQ87008.1,
RC ECO:0000313|Proteomes:UP000255139};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; UGJE01000002; STQ87008.1; -; Genomic_DNA.
DR EMBL; JRPD02000010; TLE00181.1; -; Genomic_DNA.
DR RefSeq; WP_034558626.1; NZ_UGJE01000002.1.
DR AlphaFoldDB; A0A099TWC4; -.
DR STRING; 216.LS73_07435; -.
DR OrthoDB; 5295340at2; -.
DR Proteomes; UP000029922; Unassembled WGS sequence.
DR Proteomes; UP000255139; Unassembled WGS sequence.
DR GO; GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF85; DEATH RESISTOR ADH DOMAIN CONTAINING TARGET, ISOFORM C; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:STQ87008.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000255139};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 26..356
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 365 AA; 40069 MW; 7C89EB22C8F08193 CRC64;
MLLKENLIQA QNGQRITAKG YAVAHKSDTF KPFSFSRHAL GENDILIEIL FAGICHSDIH
SAREEWHKGI FPMVPGHEIA GRVVAVGSNV NKFKVGDYAG VGCMVNSCGE CEACKRSQEQ
FCENGKCVFT YDCRDCFHDN EPTYGGYSNN IVVSEKFAVN FPQDAPLEKV APLLCAGITT
YSPIKFSKVK AGDKVAVAGF GGLGVMALKY AIKMGAEVSV FARNKNKEKE ALELGAKTLY
TDTKGVKERF DFIISTIPTA YDINAYAELL KFGGEMAIVG LPPASENLKI DLTRLVFAAG
KKVYGSLIGG MKETQEMLDF SLKHKIYPET EVISVEQINE AYENLISGKA KFRYVIDMSS
IKGQE
//