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Database: UniProt
Entry: A0A099WJW3_9LIST
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ID   A0A099WJW3_9LIST        Unreviewed;       614 AA.
AC   A0A099WJW3;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   ORFNames=EP56_06760 {ECO:0000313|EMBL:KGL45252.1};
OS   Listeriaceae bacterium FSL A5-0209.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae.
OX   NCBI_TaxID=1497679 {ECO:0000313|EMBL:KGL45252.1, ECO:0000313|Proteomes:UP000029855};
RN   [1] {ECO:0000313|EMBL:KGL45252.1, ECO:0000313|Proteomes:UP000029855}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FSL A5-0209 {ECO:0000313|EMBL:KGL45252.1,
RC   ECO:0000313|Proteomes:UP000029855};
RA   den Bakker H.C.;
RT   "Novel Listeriaceae from food processing plants.";
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KGL45252.1}.
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DR   EMBL; JNEZ01000011; KGL45252.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A099WJW3; -.
DR   STRING; 1497679.EP56_06760; -.
DR   eggNOG; COG0323; Bacteria.
DR   Proteomes; UP000029855; Unassembled WGS sequence.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd00782; MutL_Trans; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00149};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00149}.
FT   DOMAIN          208..326
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          428..570
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
SQ   SEQUENCE   614 AA;  68709 MW;  4B1E80A628FE4F10 CRC64;
     MAHIIELTDA LSNKIAAGEV VERPASVVKE LVENAIDAKS TVIDVLVEEG GLNKITIIDN
     GVGIRAEEVS VAFKRHATSK IKNEHDLFRV HTLGFRGEAL PSIASVSFLE MTTATGDGAG
     TKIVVEGGKE IEKHSAQARK GTEIQVSNLF FNTPARLKYL KSLHTELGNI TDIMNRLALS
     HPEISFRFSH NGKSLLKTNG NGDLQQVMAS IYGLAVAKKM IPIQAESLDF KLTGYAALPE
     VNRSNRNYIS TIVNGRFIKN YALVRAIQDG YHTLLPIGRF PILVLQIEMD PLIVDVNVHP
     AKLEVRLSKE AELGQFIAST LKAAFHKEQL IPDAAPSKRQ KLASEQLAIN FDKEEEPEEV
     VVEAPKPVVT PTYSTAPKTQ MELPTSDALP DEDPLFINED FAAYDVAPKM EEAAPVEVPK
     ERMPKMYPVG QVHATYIVAQ NETGMYLIDQ HAAQERIKYE FYREKIGEVD RELQQLLVPI
     VLDFSTDEFI KLRDQKAKLE EVGVFLENFG QNSFIIREHP TWLPKGEEES TLRDILDEAL
     TKPQVSIHKL REDAAIMMSC KKSIKANHYL TQADMEKLLD TLREANDPFT CPHGRPVIIS
     YSTYELEKMF KRIM
//
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