ID A0A099ZI41_TINGU Unreviewed; 4130 AA.
AC A0A099ZI41;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Dynein heavy chain 8, axonemal {ECO:0000313|EMBL:KGL82064.1};
DE Flags: Fragment;
GN ORFNames=N309_15386 {ECO:0000313|EMBL:KGL82064.1};
OS Tinamus guttatus (White-throated tinamou).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Tinamiformes; Tinamidae; Tinamus.
OX NCBI_TaxID=94827 {ECO:0000313|EMBL:KGL82064.1, ECO:0000313|Proteomes:UP000053641};
RN [1] {ECO:0000313|EMBL:KGL82064.1, ECO:0000313|Proteomes:UP000053641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N309 {ECO:0000313|EMBL:KGL82064.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KL894906; KGL82064.1; -; Genomic_DNA.
DR STRING; 94827.A0A099ZI41; -.
DR Proteomes; UP000053641; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF15; DYNEIN AXONEMAL HEAVY CHAIN 8; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053641}.
FT DOMAIN 1481..1625
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1762..1915
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2088..2236
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 2697..2776
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2933..2981
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KGL82064.1"
FT NON_TER 4130
FT /evidence="ECO:0000313|EMBL:KGL82064.1"
SQ SEQUENCE 4130 AA; 472737 MW; 472B128583851466 CRC64;
QITEMITIVQ TFSALSMSTI EGIDIMAVKF KNIYQSVQKK QYDILDPRKT EFDADFVDFM
AKIEGLEMQI QTFMRTCFGR ILSSQNALQL LQRFQNLRMP CLQEEIAHTV GCILQHYVAE
LEATKKLYQI QKDDPPLARN MPPVAGKILW VRQLFRRISE PIDYFHKNSS ILKSAEGKAV
VRLYNKISYV LVEFEVLYHN AWVKEISQLQ YALQATLLVR HPKTGKFLVN FDPKIPEIVR
ETKCMIKLGL EVPEQAKRIV KIENNLKSNK LYLEGLLQCY EDLCQETPTV FVNLMAPKMK
KMEAVLRQGL TMLTWSSLTL DSFFQEVDEV LYMYKQLLKK VNDLSEVQID LILKEISNTL
LIVLPIDGPT KVDEMLSSNE LYTKECAELL NHKSMHIEDA VQELISVFET IYDIKYSKKT
SKKRTSPAID FLSHIYKIYV SVFYVACIAL WPFSVDISLS AQLSLHEGIK CKEMVAYFSH
QLLDSLLKAT RLSLDTLKRR IFVSRSTYGR TSYFVRASKT EEIISFLKAE VHLAIPNVVM
VPSLDDIQQA INRMIQLILE VSRGVAHWGQ RHLQKPNIIS ESGTRHTAST GKLGKKEEKG
VEEVLTRKLR NFYPGVAEHK DISKLVVLLS SSVNSIRDVA SEALQDFQKY KVLWTEDRDA
KVQQFLASCP SLTEIRAEIL HYATFEQEME DLKPIILVGP IELHTGPLKL ALSIEAKAWK
MLLCRYLNEE YKKKMTDMMS FITEYLKKLS RPLRDLDDVR FAMEALSDIR DNKIQMDMTL
GPIEEAYAIL NRFEIEVTKE ESEGVDTLRY SFNKLQTKAS RVQDELVQVQ PKFKSNLLES
VAVFREDVSN FETSYETEGP MVPNIPPQEA SNRLQIFQAN FDELWRKFIT YSSGEQLFGL
PVTDYEVLHK VRKELGLLQK LYGLYDTVMN NISGYYEILW SDVDIEKINA ELLDFQNRCR
KLPKGLKNWQ AFLDLKKRID DFSESCPLLE MMTNKAMKQR HWNRIAETTG HQFDIESDTF
CLRNIMEAPL LQHKDDIEDI CISATKEKDI EAKLSQIVDS WGGQVLSFSP FKGRGELLLK
GTESSEIITL MEDSLMILGS LLSNRYNAPF KKEIQSWIYK LSSSTDIIEE WLVVQNLWVY
LEAVFVGGDI AKQLPQEAKR FQNIDKSWIK IMQRAHENPN VINCCVGDET MGQLLPHLHE
QLEVCQKSLT GYLEKKRLLF PRFFFVSDPA LLEILGQASD SHTIQPHLPS ISDNINEVQF
HPKDYDRITA VISREGEKIA LDTPVIAKGP VELWLLDLLR VQQNSLHAII RAAYYQVSDP
GYQLLTFLNH FPAQVGLLGI QMLWTHDAEE ALHNAKDDRK IMHVTNARFL DILNTLISQT
THDLSKFDRV KFETLVTIHV HQRDIFDDLV KMHIRSPTDF EWLKQCRFYF KEDFDQVLVS
ITDVDFVYQN EFLGCTDRLV ITPLTDRCYI TLAQALGMNM GGAPAGPAGT GKTETTKDMG
KALGKYVVVF NCSDQMDFRG LGRIFKGLAQ SGSWGCFDEF NRIELPVLSV AAQQIYIILT
ARKERKKQFI FSDGDTVDLN PEFGIFLTMN PGYAGRQELP ENLKIQFRTV SMMVPDRQII
MRVKLASCGF IDNVILAQKF FVLYKLCEEQ LTKQVHYDFG LRNILSVLRT LGSQKRARPN
ESELSIVMRG LRDMNLSKLV DEDEPLFLSL INDLFPGLQL DSNTYAELQA AVANQVEEAG
LINHPPWNLK LVQLYETSLV RHGLMTLGPS GSGKTTVITM LMRALTECGH PHREMRMNPK
AITAPQMFGR LDTATNDWTD GIFSTLWRKT LKSKKGENVF LVLDGPVDAI WIENLNSVLD
DNKTLTLANG DRIPMSPTCK LLFEVHNIEN ASPATVSRMG MVYISSSALS WRPILQAWLK
KRSAQEAEVL QSLYDRIFEP AYTYMKLNLN PKMELLECNY IVQSINLLEG LIPSKEDGGL
STVFHLHKLF SFGLMWSLGA LLELDSRDKL EAFIREHDNK LDLPEIAPGT NQTMYELFVT
DYGDWEHWSK RVQEYVYPTD SVPDYASILV PNVDNVRTQF LIDTIAKQHK VFLLTGEQGT
AKTVMIKAYV KKYDPEEHLS KCLNFSSATE PFMFQRTIES YVDKRIGSTY GPPGGRKMTV
FIDDINMPVV NEWGDQVTNE IVRQMMEMEG MYSLDKPGDF TTIVDVQLVA AMIHPGGGRN
DIPQRLKRQF SVFNCTLPSN ASIDKIFGVI GCGYFHPCRK FSSEVCDMVK KLVPAGRILW
QWTKTKMLPT PSKFHYIFNL RDLSRIWQGM LTIKAEECSD STVLTTLFKH ECSRVIADRF
ITDEDRAWFD KTTIKAIEEY VDTSLAEAVQ TEPYFVDFLR EMPEPTGEEP EDFVFEPPKI
YEEIPSFEFL CEKLQMYQRQ YNEYIRGSFL DLVFFKDAMT HLVKISRIIR TACGNALLVG
VGGSGKQSLS RLATFIAGYK IFQITLTRSY NVSNLTDDLK LLYRTAGAEG KGITFIFTDN
EIKEESFLEY LNNLLSSGEI ANLFARDELD EITQGLIPLM KKEMPRCPPT FDNLYEYFIT
RAKKNLHVVL CFSPVGEKFR ARSLKFPGLI SGCTMDWFSR WPKEALVAVA SYFLSEFNMV
CSASVKREIV ETMGLFHDIV SESCENYFQR YRRRAHVTPK SYLSFINGYK EVYTEKLANI
NEQAERMQIG LSKLMEASES VAKLSQELAV KEKELALASV KADKVLAEVT ISAEAAAKVK
NEVQGVKDKA QRIVDEIDSE KVIAESKLEA ARPALEEAEA ALNTIRPADI ATVRKLAKPP
HLIMRIMDCC LLLFQKQVDP VTMDPEKPCC KPSWGESLKI MSGPFLQSLQ QFPKDTINEE
TVELLQPYFN MEDYTLECSK KVCGNVAGLL SWTQAMAIFY GVNREVLPLK ANLAKQEGRL
KVANAELAKA QEVLDEKQAE LDKVQAKFDA AMKEKMDLLN DAETCRRKMQ AASALIDGLS
GEKVRWTKQS KEFKSQINRL VGDVLLCTGF LSYCGPFNQN FRNLLLKDLW ETEMKAHKIP
FSEDLNLISM LVDPPTISEW NLQGLPGDDL SIQNGIIVTK ATRYPLLVDP QTQGKTWIKK
KEEDNELQVT TLNHKYFRTH LEDSLSLGRS LVIEDIGEEL DPVLDNILEK NFIKSGTSFK
VKVGDKEVEV MNSFRLYITT KLPNPAFTPE INAKTSVIDF TVTMKGLENQ LLRRVILTEK
QELEAERIKL MEDVTFNKRK MKELEDNLLY KLSATKGSLV DDESLIGVLR TTKQTAAEVA
EKLSVAAETQ VKINTAQEEY RPAATRGSIL YFLITEMSMV NNMYQTSLAQ FLKLFDQSMA
KSEKSPLPQK RISNIIEFLT FETYAYSVRG LYENHKFLFT LLLTLKIDLE RGHVKNKEFH
ALIRGGAALD LKACPPKPFR WILDMTWLNL VELSKLPQFA EIMNQVARNE KGWKSWFDKD
APEEEVIPDG YNDSLDTCRK LLLIRSWCPD RTVSQARKYI ADSLDEKYTE PVILNLEKTW
EESDKRTPLI CFLSMGSDPT IQIDSLARKL KLECRTISMG QGQEVHARKF TQMAMHQGGW
VLLQNCHLGL DFMDELLETL LTAEIPNETF RVWITTEPHP KFPITLLQIA IKFTNEPPQG
VRAGLKRTFS GINQDLLDVS NMPMWKPLLY TVAFLHSTVQ ERRKFGPLGW NIPYEFNSAD
FTASVQFIQN HLDECDIKKG ISWSTVRYMI GEVQYGGRVT DDFDKRLLNC FARVWFNERM
FDSSFCFYTG YKIPVCKTLE QYFEYIQSLP AMDSPEVFGL HPNADITYQS NTAADVLDTI
TNIQPKESGG GVGETREAIV YRLAEDMLDK LPPDYVPHEA TRLIKMGHLN SMNIFLRQEI
DRMQKVITVL RNSLNDLKLA IEGTIIMSEA STSIDALDNM YDARIPQIWK RVSWDSSTLG
FWFTELLERN SQFSTWIFEG RPNVFWMTGF FNPQGFLTAM RQEATRAHKG WALDTVTIHN
EVLKQTKEEI TVPPSEGVYI YGLYLEGAGW DRRNGKLIES TPKILFVQLP VVHIFAINTA
IPKDSKLYVC PIYKKPRRTD LTYITVIYLR TVLSADHWIL RGVALLCDIK
//
