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Database: UniProt
Entry: A0A099ZIW7_TINGU
LinkDB: A0A099ZIW7_TINGU
Original site: A0A099ZIW7_TINGU 
ID   A0A099ZIW7_TINGU        Unreviewed;      4917 AA.
AC   A0A099ZIW7;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   25-OCT-2017, entry version 20.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|EMBL:KGL80765.1};
DE   Flags: Fragment;
GN   ORFNames=N309_01010 {ECO:0000313|EMBL:KGL80765.1};
OS   Tinamus guttatus (White-throated tinamou).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Palaeognathae; Tinamiformes; Tinamidae; Tinamus.
OX   NCBI_TaxID=94827 {ECO:0000313|EMBL:KGL80765.1, ECO:0000313|Proteomes:UP000053641};
RN   [1] {ECO:0000313|EMBL:KGL80765.1, ECO:0000313|Proteomes:UP000053641}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N309 {ECO:0000313|EMBL:KGL80765.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; KL893424; KGL80765.1; -; Genomic_DNA.
DR   Proteomes; UP000053641; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053641};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KGL80765.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053641};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4229   4247       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4450   4470       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4524   4543       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4660   4681       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4718   4739       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4794   4817       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       59    114       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      121    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    229       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      235    292       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      300    357       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      560    757       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      973   1170       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1298   1510       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3972   4007       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     4367   4388       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KGL80765.1}.
FT   NON_TER    4917   4917       {ECO:0000313|EMBL:KGL80765.1}.
SQ   SEQUENCE   4917 AA;  559467 MW;  4F39B6D103CD3FE7 CRC64;
     NVPPDLSICT FVLEQSLSVR ALQEMLANTE EKAEGGLILF QGPTMSFLFV FQSAQGGGHR
     TLLYGHAILL RHSYSGMYLC CLSTSRSSMD KLAFDVGLQE NTTGEACWWT IHPASKQRSE
     GEKVRVGDDL ILVSVSSERY LHLSYGNGSL HVDAAFQQTL WSVAPISSGS EVAQGYLIGG
     DVLRLLHGHM DECLTVPSGE HGEEQRRTVH YEGGAVSIHA RSLWRLETLR VAWSGSHIRW
     GQPFRLRHIT TGKYLSLLDD RSLLLTDKEQ ADVKSTAFCF RSSKEKLDVG TRKEVDGMGA
     PEIKYGDSIC FIQHVDTGLW LTYQSADAKS VRMGSVQRKA IMHHEGHMDD GLTLSRSQHE
     ESRTARVIRS TVFLFNRFIR GLDALSKKAK SSTVDLPIES VSLSLQDLIG YFHPPDEHLE
     HEDKQNRLRA LKNRQNLFQE EGMINLVLEC IDRLNVYSSA AHFGDVAGKE AGEAWKSILN
     SLYELLAALI RGNRKNCAQF SGSLDWLISR LERLEASSGI LEVLHCVLVE SPEALNIIKE
     GHIKSIICLL DKHGRNHKVL DVLCSLCVCH GVAVRSNQHL ICDNLLPGRD LLLQTRLVNH
     VSSMRPNIFL GISEGSAQYR KWYYELMVDH LEPFVTAEST HLRVGWASTE GYSPYPGGGA
     EWGGNGVGDD LYSYGFDGLH LWSGCVARTV NSPNQHLLRT DDVISCCLDL SAPSISFRIN
     GQPVQGMFEN FNIDGLFFPV VSFSACLVRF LLGGRHGEFK FLPPPGYAPC FEAVLPKEKL
     KVEHSREYKQ DRSYTRDLLG PTISLSQAAF TPVPVDTSQI VLPPHLERIR EKLAENIHEL
     WVMNKIELGW QYGPVRDDNK RQHPCLVEFS KLPEQERNYN LQMSLETLKT LLALGSHVGI
     ADEHAEEKVK KMKLPKNYQL SSGYKPAPMD LSFIKLTPSQ EAMVDKLAEN AHNVWARDRI
     RQGWTYGIQQ DVKNRRNPRL VPYALLDDRT KKSNKDSLRE AVRTLLGYGY NLEAPDQDHA
     TRLDMCMGII EKFRIFRTEK TYAVKTGKWY FEFEAVTAGD MRVGWTRPGC LPDQELGSDE
     EAFVFDGFKA QRWHQGNEHF GRSWLAGDVV GCMVDMNEHT MMFTLNGEIL LDDSGSELAF
     KDFEVGDGFL PVCSLGLSQV GRMNFGKDVS TLKYFTICGL QEGYEPFAVN TNRDITIWLS
     KRLPQFLPVP LNHEHIEVLR IDGTIDSCPC LKVTQKSFGS QNSKTDVMFF RLSMPIECAE
     VFSRTAAGGL PGTGLYGPKN DLEDYDADSD FEVLMKTAHG HLVPDRTERE KEVTKTELNN
     HKDCAQEKPS RLKQRFMLRR TKPDYSTSHS ARLTEDVLAD DRDDYDYLMQ TSTYYYSVRI
     FPGQEPANVW VGWITSDFHQ YDTTFDLDRV RTVTVTLGDE KGKVHESIKR SNCYMVCAGE
     SMSPGQGRNN NGLEIGCLVD AASGLLTFTA NGKELGTYYQ VEPSTKLFPA VFAQATSPNV
     FQFELGRIKN VMPLSAGLFK SEHKNPVSQC PPRLHVQFLT HVLWSRVPNH FLKVDVSRIS
     ERQGWMIQCM NPLQFMALHI PEENRTIDIL ELTEQEELLK FHYHTLRLYS AVCALGNNRV
     AHAMCSHVDE SQLLYAIENK YMPGLLRAGY YDLLIDIHLN TYATARLMMN NEFIVPMTDE
     TKSITLFPDE NKKHGLPGIG LSTSLRPRMQ FSSPSFVSIS SECFQFSPEF PLEILKAKTI
     EMLTEAVQEG SLHVRDPVGG STEFLFVPLI KLFYTLLIMG IFHNGDLKHI LQLIEPRVFK
     EAMSQEDESD FSEKELSSDE LKAEEGEEET KGEQVPKEGL LQMKLPEPVK LQMCHLLQYL
     CDCQVRHRIE AIVAFSDDFV ARLQENQRFR YNEVMQALNM SAALTARKTK EFRSPPQEQI
     NMLLNFKDDK NDCPCPEEIR DQLLDFHEDL MAHCGIELDE DGSLDGNNDL TIRGRLLYLM
     EKVTYLKKKQ TEKPVDDDAK TSSTLQQLIS DTMVRWAQES VIEDPELVRA MFVLLHRQYD
     GIGGLVRALP KTYTINSVSV EDTINLLASL GQIRSLLSVR MGKEEEKLMI RGLGDIMNNK
     VFYQHPNLMR ALGMHETVME VMVNVLGGGE SKEITFPKMV ANCCRFLCYF CRISRQNQKA
     MFDHLSYLLE NSSVGLASPS MRGSTPLDVA AASVMDNNEL ALALREPDLE KVVRYLAGCG
     LQSCPLLVSK GYPDIGWNPV EGERYLDFLR FAVFCNGESV EENANVVVRL LIRRPECFGP
     ALRGEGGNGL LAAMEEAIKI SEDPTRDGRS PSNGSSKTLE MEEQEDDTIH MGNAIMTFYA
     ALIDLLGRCA PEMHLLHAGK GEAIRIRSIL RSLIPLEDLV GVISIPFHMP TIAKDGTVVE
     PDMSAGFCPD HKAAMVLFLD RVYGIEDQDF LLHLLEVGFL PDLRAAASLD TAALSATDMA
     LALNRYLCTA VLPLLTRCAP LFAGTEHHAS LIDSLLHTVY RLSKGCSLTK AQRDSIEECL
     LSICGQLRPS MMQHLLRRLV FDVPLLNEHA KMPLKLLTNH YERCWKYYCL PGGWGNFGAA
     SEEELHLSRK LFWGIFDALS QKKYEQELFK LALPCLSAVA GALPPDYMES NYVSMMEKQS
     SMDSDGNFNP QPVDTSNITI PEKLDYFINK YAEHSHDKWS MEKFANGWVY GETYSESAKV
     QPLMKQYKLL SEKEKEIYRW PIKESLKTML AWGWRIERTR EGDSMALYNR TRRISQTSQI
     SVDTAHGYSP RAIDMSNVTL SRDVHAMAEM MAENYHNTWA KKKKLELEAK GGGNHPLLVP
     YDTLTAKEKA KDREKAQDIL KFLQINGYVV SRGLKDLELD TPSIEKRFAY SFLQQLIRYV
     DEAHQYILEF DGGSRGKGEH FPYEQEIKFF AKVVLPLIDQ YFKNHRLYFL SAASRPLSSG
     GHASNKEKEM VTSLFCKLGV LVRHRISLFG NDAASIVNCL HILGQTLDAR TVMKTGLESV
     KMALRAFLDN AAEDLEKTME NLKQGQFTHT RNQPKGVTQI INYTTVALLP VLSSLFEHIG
     QHQFGEDLIL EDVQVSCYRI LASLYALGTS KSIYVERQRS ALGECLAAFS GAFPVAFLET
     HLNKHNTYSI YNTKNARDRA VLNLPTSVEE VCPNIPSLVK LMEEIVELAE SGIRYTQMPH
     IMEVILPMLC SYMSHWWEHG PENNPDKAEM CCTALTSEHM NTLLGNILKI IYNNLGIDEG
     AWMKRLAVFS QPIISKAKPQ LLKTHFLPLM DKLKKKAAVV VSDEEHLRAE GRGDMSEAEL
     LILDEFTTLA RDLYAFYPLL IRFVDYNRAK WLKEPNPEAE ELFRMVAEVF IYWSKSHNFK
     REEQNFVVQN EINNMSFLIT DTKSKMSKAA VSDQERKKMK RKGDRYSMQT SLIVAALKRL
     LPIGLNICAP GDQELIALAK NRFSMKDTED EVRDIIRSNL HLQGKLEDPA IRWQMALYKD
     LPNRTEDSSD PEKTVERVLD IANVLFHLEE RCVIYFFPVY FIYQVEHPQR SKKAVWHKLL
     SKQRKRAVVA CFRMAPLYNL PRHRAVNLFL QGYDKSWIET EEHYFEDKLI EDLAKPGEEP
     PEEDEGLKRV DPLHQLILLF SRTALTEKCK LDEDFLYMAY ADIMAKSCHD EDDDDGEEEV
     KSFEEKEMEK QKLLYQQARL HDRGAAEMVL QTISASKGEM GPMVAATLKL GIAILNGGNS
     TVQQKMLDYL KDKKDVGFFQ SLAGLMQSCS VLDLNAFERQ NKAEGLGMVT EEGSGEKVMQ
     DDEFTCDLFR FLQLLCEGHN SDFQNYLRTQ TGNNTTVNII ISTVDYLLRV QESISDFYWY
     YSGKDVIDEQ GQRNFSKAIQ VAKQVFNTLT EYIQGPCTGN QQSLAHSRLW DAVVGFLHVF
     AHMQMKLSQD SSQIELLKEL MDLQKDMVVM LLSMLEGNVV NGTIGKQMVD MLVESSNNVE
     MILKFFDMFL KLKDLTSSDA FKEYDPDGKG IISKRDFHKA MESHKHYTQS ETDFLLSCAE
     TDENETLDYE EFVKRFHEPA KDIGFNVAVL LTNLSEHMPH DTRLQTFLEL SESVLNYFHP
     FLGRIEIMGS AKRIERVYFE ISESSRTQWE KPQVKESKRQ FIFDVVNEGG EKEKMELFVN
     FCEDTIFEMQ LAAQISESDL NERSANKEEN EKDKPEDQDP RMGFFSLVTM KSALVALKYN
     LMTLMKMLSV KSLKKQMKKV KKMTMKDMIL ALFSSYWSIL MGLLHFACSV FRGFFRIVYS
     LLLGGSLVEG AKKIKVAELL ANMPDPTQDE VRGEGEEGER KPTETALPAE DLTDLRTLSD
     DSDLLSDIFG LDLKREGGQY KLIPHNPNAG LSDLLSTPSI VPMPEVQEKA QEQVKEDEKE
     EKEETKSEPE KAEGEDGEKE DKAKEDKGKQ KLRQLHTHRY GEPDVQESAF WKKIIAYQQK
     LLNYFARNFY NMRMLALFVA FAINFILLFY KVSTSAVAEE KEVPVVPAGE SSKLNSLESD
     NSRVIAVHYV LEESSGYMEP TLRILAILHT VISFFCIIGY YCLKVPLVIF KREKEVARKL
     EFDGLYITEQ PSEDDIKGQW DRLVINTQSF PNNYWDKFVK RKVMDKYGEF YGRDRISELL
     GMDKAALDFS DAREKKKPKK DSSLSAVLNS IDVKYQMWKL GVVFTDNSFL YLAWYMTMSI
     LGHYNNFFFA AHLLDIAMGF KTLRTILSSV THNGKQLVLT VGLLAVVVYL YTVVAFNFFR
     KFYNKSEDGD MPDMKCDDML TCYMFHMYVG VRAGGGIGDE IEDPAGDEYE IYRIIFDITF
     FFFVIVILLA IIQGLIIDAF GELRDQQEQV KEDMETKCFI CGIGNDYFDT VPHGFETHTL
     QEHNLANYLF FLMYLINKDE TEHTGQESYV WKMYQERCWE FFPAGDCFRK QYEDQLN
//
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