ID A0A0A0KJN5_CUCSA Unreviewed; 744 AA.
AC A0A0A0KJN5;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Cucumisin-like {ECO:0008006|Google:ProtNLM};
GN ORFNames=Csa_5G141040 {ECO:0000313|EMBL:KGN49930.1};
OS Cucumis sativus (Cucumber).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3659 {ECO:0000313|EMBL:KGN49930.1, ECO:0000313|Proteomes:UP000029981};
RN [1] {ECO:0000313|EMBL:KGN49930.1, ECO:0000313|Proteomes:UP000029981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 9930 {ECO:0000313|Proteomes:UP000029981};
RX PubMed=19881527; DOI=10.1038/ng.475;
RA Huang S., Li R., Zhang Z., Li L., Gu X., Fan W., Lucas W.J., Wang X.,
RA Xie B., Ni P., Ren Y., Zhu H., Li J., Lin K., Jin W., Fei Z., Li G.,
RA Staub J., Kilian A., van der Vossen E.A., Wu Y., Guo J., He J., Jia Z.,
RA Ren Y., Tian G., Lu Y., Ruan J., Qian W., Wang M., Huang Q., Li B.,
RA Xuan Z., Cao J., Asan null, Wu Z., Zhang J., Cai Q., Bai Y., Zhao B.,
RA Han Y., Li Y., Li X., Wang S., Shi Q., Liu S., Cho W.K., Kim J.Y., Xu Y.,
RA Heller-Uszynska K., Miao H., Cheng Z., Zhang S., Wu J., Yang Y., Kang H.,
RA Li M., Liang H., Ren X., Shi Z., Wen M., Jian M., Yang H., Zhang G.,
RA Yang Z., Chen R., Liu S., Li J., Ma L., Liu H., Zhou Y., Zhao J., Fang X.,
RA Li G., Fang L., Li Y., Liu D., Zheng H., Zhang Y., Qin N., Li Z., Yang G.,
RA Yang S., Bolund L., Kristiansen K., Zheng H., Li S., Zhang X., Yang H.,
RA Wang J., Sun R., Zhang B., Jiang S., Wang J., Du Y., Li S.;
RT "The genome of the cucumber, Cucumis sativus L.";
RL Nat. Genet. 41:1275-1281(2009).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; CM002926; KGN49930.1; -; Genomic_DNA.
DR RefSeq; XP_004145974.1; XM_004145926.2.
DR AlphaFoldDB; A0A0A0KJN5; -.
DR MEROPS; S08.A13; -.
DR EnsemblPlants; KGN49930; KGN49930; Csa_5G141040.
DR GeneID; 101213928; -.
DR Gramene; KGN49930; KGN49930; Csa_5G141040.
DR KEGG; csv:101213928; -.
DR eggNOG; ENOG502QRA7; Eukaryota.
DR OMA; HKLANME; -.
DR OrthoDB; 11910at2759; -.
DR Proteomes; UP000029981; Chromosome 5.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02120; PA_subtilisin_like; 1.
DR CDD; cd04852; Peptidases_S8_3; 1.
DR Gene3D; 2.60.40.2310; -; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034197; Peptidases_S8_3.
DR InterPro; IPR010259; S8pro/Inhibitor_I9.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR InterPro; IPR045051; SBT.
DR InterPro; IPR041469; Subtilisin-like_FN3.
DR PANTHER; PTHR10795:SF714; CUCUMISIN; 1.
DR PANTHER; PTHR10795; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN; 1.
DR Pfam; PF17766; fn3_6; 1.
DR Pfam; PF05922; Inhibitor_I9; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000029981};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..744
FT /note="Cucumisin-like"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001965380"
FT DOMAIN 31..110
FT /note="Inhibitor I9"
FT /evidence="ECO:0000259|Pfam:PF05922"
FT DOMAIN 132..582
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 639..735
FT /note="Subtilisin-like protease fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF17766"
FT ACT_SITE 140
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 204
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 533
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 744 AA; 80676 MW; 78EB08C80E45255F CRC64;
MSSLSRLLFL CLCFSLLFST SVSEDDQYRK TYIVYMGSHH QVSSAPLSSH HHMRILQEAV
GSTFAPHCLL HSYKRSFNGF VAKLTEIEAK KVSEMEGVIS VFPNGELQLH TTRSWDFMGM
SEQVERVPSV ESDIIVGVFD TGIWPESPSF LDHGYGPPPP KWKGSCEVSA NFSCNNKIIG
ARSYRSDGRY PIDDIKGPRD SNGHGTHAAS TVAGGLVRQA SMLGLGMGTA RGGVPSARIA
AYKVCWSDTC SDADVLAAFD DAIADGVDII SMSVGPKRPR PNYFQDPIAI GTFHAMRNGI
LTSTSAGNEG PLHFTVTNFS PWALSVAAST SDRRFLTAVQ LGDGRKFNGV TINTFDLNGT
QYPLVYAGNI PNVTGGFNGS FSRFCLRDSV DRELVKGKIA ICDSFVSPSD VGSLESAVGI
IMQDRSPKDL TFAFPLPASH LGIQQRPLIS SYLNSTRIPT ATILKSTGLK LQVAPLVASF
SSRGPNPTSP YILKPDVIGP GVEILAAWSP LRSPSNAKGD NRKLLFNIIS GTSMACPHAT
AVAAYVKSFH PSWSPAALKS ALITTAFPMR GDLYPEAEFA YGSGHINPLG AVNPGLIYNA
SETDYIRFLC DEGYNTTFLR IITKDNSTCS TTQSIRVYDL NYPSFALFTH ISTPFSQTSK
RRVTNVGSTN STYKATISAP SGLNITVNPS ILSFKALEEE LNFEVTFEGK IDRSIESASL
VWDDGVHKVR SPIIVFDSDT FTRN
//
