ID A0A0A0MRF2_HUMAN Unreviewed; 263 AA.
AC A0A0A0MRF2;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Osteoclast associated Ig-like receptor {ECO:0000313|Ensembl:ENSP00000351145.4};
GN Name=OSCAR {ECO:0000313|Ensembl:ENSP00000351145.4};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000351145.4, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000351145.4, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000351145.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC245052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_573399.2; NM_133169.4.
DR AlphaFoldDB; A0A0A0MRF2; -.
DR SMR; A0A0A0MRF2; -.
DR MassIVE; A0A0A0MRF2; -.
DR PeptideAtlas; A0A0A0MRF2; -.
DR Antibodypedia; 32787; 269 antibodies from 27 providers.
DR DNASU; 126014; -.
DR Ensembl; ENST00000358375.9; ENSP00000351145.4; ENSG00000170909.14.
DR GeneID; 126014; -.
DR MANE-Select; ENST00000358375.9; ENSP00000351145.4; NM_133169.6; NP_573399.2.
DR UCSC; uc061cmc.1; human.
DR CTD; 126014; -.
DR HGNC; HGNC:29960; OSCAR.
DR VEuPathDB; HostDB:ENSG00000170909; -.
DR GeneTree; ENSGT01100000263562; -.
DR HOGENOM; CLU_021100_4_0_1; -.
DR OrthoDB; 5263922at2759; -.
DR BioGRID-ORCS; 126014; 19 hits in 1147 CRISPR screens.
DR GenomeRNAi; 126014; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000170909; Expressed in monocyte and 94 other cell types or tissues.
DR ExpressionAtlas; A0A0A0MRF2; baseline and differential.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0038064; F:collagen receptor activity; IEA:Ensembl.
DR GO; GO:0038094; P:Fc-gamma receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0072674; P:multinuclear osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0045780; P:positive regulation of bone resorption; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR PANTHER; PTHR11738:SF189; OSTEOCLAST-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR; 1.
DR Pfam; PF13895; Ig_2; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
PE 1: Evidence at protein level;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Proteomics identification {ECO:0007829|MaxQB:A0A0A0MRF2,
KW ECO:0007829|PeptideAtlas:A0A0A0MRF2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..263
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001967220"
FT DOMAIN 38..121
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 135..215
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
SQ SEQUENCE 263 AA; 28806 MW; 4DF7E0E4A4E1E866 CRC64;
MALVLILQLL TLWPLCHTDI TPSVPPASYH PKPWLGAQPA TVVTPGVNVT LRCRAPQPAW
RFGLFKPGEI APLLFRDVSS ELAEFFLEEV TPAQGGSYRC CYRRPDWGPG VWSQPSDVLE
LLVTEELPRP SLVALPGPVV GPGANVSLRC AGRLRNMSFV LYREGVAAPL QYRHSAQPWA
DFTLLGARAP GTYSCYYHTP SAPYVLSQRS EVLVISWEDS GSSDYTRGNL VRLGLAGLVL
ISLGALVTFD WRSQNRAPAG IRP
//
