ID A0A0A0MRI8_HUMAN Unreviewed; 858 AA.
AC A0A0A0MRI8;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF {ECO:0000313|Ensembl:ENSP00000355667.2};
DE Flags: Fragment;
GN Name=OBSCN {ECO:0000313|Ensembl:ENSP00000355667.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000355667.2, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000355667.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H.,
RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C.,
RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R.,
RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.,
RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.,
RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R.,
RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D.,
RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A.,
RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S.,
RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A.,
RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S.,
RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A.,
RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L.,
RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z.,
RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C.,
RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M.,
RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000355667.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL353593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL359510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL670729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0A0MRI8; -.
DR SMR; A0A0A0MRI8; -.
DR MassIVE; A0A0A0MRI8; -.
DR PeptideAtlas; A0A0A0MRI8; -.
DR Antibodypedia; 11615; 58 antibodies from 16 providers.
DR Ensembl; ENST00000366706.7; ENSP00000355667.2; ENSG00000154358.23.
DR UCSC; uc057qef.1; human.
DR HGNC; HGNC:15719; OBSCN.
DR VEuPathDB; HostDB:ENSG00000154358; -.
DR GeneTree; ENSGT00940000154756; -.
DR HOGENOM; CLU_013555_0_0_1; -.
DR ChiTaRS; OBSCN; human.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000154358; Expressed in hindlimb stylopod muscle and 120 other cell types or tissues.
DR ExpressionAtlas; A0A0A0MRI8; baseline and differential.
DR CDD; cd00096; Ig; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR35971:SF4; OBSCURIN; 1.
DR PANTHER; PTHR35971; SI:DKEY-31G6.6; 1.
DR Pfam; PF07679; I-set; 8.
DR SMART; SM00409; IG; 8.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 9.
DR PROSITE; PS50835; IG_LIKE; 5.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Proteomics identification {ECO:0007829|MaxQB:A0A0A0MRI8,
KW ECO:0007829|PeptideAtlas:A0A0A0MRI8};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 137..228
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 316..407
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 494..578
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 674..756
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 768..847
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000355667.2"
SQ SEQUENCE 858 AA; 94692 MW; 3A12E907ABBD2427 CRC64;
AGKTMAIAAQ GACRSLTIYR CEFADQGVYV CDAHDAQSSA SVKVQGRNIQ IVRPLEDVEV
MEKDGATFSC EVSHDEVPGQ WFWEGSKLRP TDNVRIRQEG RTYTLIYRRV LAEDAGEIQF
VAENAESRAQ LRVKELPVTL VRPLRDKIAM EKHRGVLECQ VSRASAQVRW FKGSQELQPG
PKYELVSDGL YRKLIISDVH AEDEDTYTCD AGDVKTSAQF FVEEQSITIV RGLQDVTVME
PAPAWFECET SIPSVRPPKW LLGKTVLQAG GNVGLEQEGT VHRLMLRRTC STMTGPVHFT
VGKSRSSARL VVSDIPVVLT RPLEPKTGRE LQSVVLSCDF RPAPKAVQWY KDDTPLSPSE
KFKMSLEGQM AELRILRLMP ADAGVYRCQA GSAHSSTEVT VEAREVTVTG PLQDAEATEE
GWASFSCELS HEDEEVEWSL NGMPLYNDSF HEISHKGRRH TLVLKSIQRA DAGIVRASSL
KVSTSARLEV RVKPVVFLKA LDDLSAEERG TLALQCEVSD PEAHVVWRKD GVQLGPSDKY
DFLHTAGTRG LVVHDVSPED AGLYTCHVGS EETRARVRVH DLHVGITKRL KTMEVLEGES
CSFECVLSHE SASDPAMWTV GGKTVGSSSR FQATRQGRKY ILVVREAAPS DAGEVVFSVR
GLTSKASLIV RERPAAIIKP LEDQWVAPGE DVELRCELSR AGTPVHWLKD RKAIRKSQKY
DVVCEGTMAM LVIRGASLKD AGEYTCEVEA SKSTASLHVE EKANCFTEEL TNLQVEEKGT
AVFTCKTEHP AATVTWRKGL LELRASGKHQ PSQEGLTLRL TISALEKADS DTYTCDIGQA
QSRAQLLVQG EAAKCARA
//
