ID A0A0A0MSI3_HUMAN Unreviewed; 200 AA.
AC A0A0A0MSI3;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Phosphotriesterase-related protein {ECO:0000256|ARBA:ARBA00020475};
DE AltName: Full=Parathion hydrolase-related protein {ECO:0000256|ARBA:ARBA00029607};
GN Name=PTER {ECO:0000313|Ensembl:ENSP00000389535.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000389535.3, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000389535.3, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0000313|Ensembl:ENSP00000389535.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|ARBA:ARBA00001968};
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Phosphotriesterase family. {ECO:0000256|PROSITE-ProRule:PRU00679}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00679}.
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DR EMBL; AL360230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001248767.1; NM_001261838.1.
DR AlphaFoldDB; A0A0A0MSI3; -.
DR SMR; A0A0A0MSI3; -.
DR MassIVE; A0A0A0MSI3; -.
DR PeptideAtlas; A0A0A0MSI3; -.
DR Antibodypedia; 25152; 125 antibodies from 26 providers.
DR DNASU; 9317; -.
DR Ensembl; ENST00000423462.6; ENSP00000389535.3; ENSG00000165983.15.
DR GeneID; 9317; -.
DR UCSC; uc031pti.1; human.
DR CTD; 9317; -.
DR HGNC; HGNC:9590; PTER.
DR VEuPathDB; HostDB:ENSG00000165983; -.
DR GeneTree; ENSGT00390000006960; -.
DR HOGENOM; CLU_1365848_0_0_1; -.
DR BioGRID-ORCS; 9317; 11 hits in 1155 CRISPR screens.
DR ChiTaRS; PTER; human.
DR GenomeRNAi; 9317; -.
DR Proteomes; UP000005640; Chromosome 10.
DR Bgee; ENSG00000165983; Expressed in anterior cingulate cortex and 178 other cell types or tissues.
DR ExpressionAtlas; A0A0A0MSI3; baseline and differential.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009056; P:catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR032466; Metal_Hydrolase.
DR InterPro; IPR001559; Phosphotriesterase.
DR PANTHER; PTHR10819; PHOSPHOTRIESTERASE-RELATED; 1.
DR PANTHER; PTHR10819:SF3; PHOSPHOTRIESTERASE-RELATED PROTEIN; 1.
DR Pfam; PF02126; PTE; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR PROSITE; PS51347; PHOSPHOTRIESTERASE_2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A0A0A0MSI3,
KW ECO:0007829|MaxQB:A0A0A0MSI3};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
SQ SEQUENCE 200 AA; 22591 MW; E5AEAAD61A94CAD9 CRC64;
MNEILHGADG TSIKCGIIGE IGCSWPLTES ERKVLQATAH AQAQLGCPVI IHPGRSSRAP
FQIIRILQEA GADISKTVMS HLDRTILDKK ELLEFAQLGC YLEYDLFGTE LLHYQLGPDI
DMPDDNKRIR RVRLLVEEGC EDRILVAHDI HTKTRLMKYG GHGYSHILTN VVPKMLLRGI
TENVLDKILI ENPKQWLTFK
//
