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Database: UniProt
Entry: A0A0A1B4B8_9GAMM
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ID   A0A0A1B4B8_9GAMM        Unreviewed;       467 AA.
AC   A0A0A1B4B8;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   20-DEC-2017, entry version 26.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AIX75393.1};
GN   ORFNames=PSNIH2_17595 {ECO:0000313|EMBL:AIX75393.1};
OS   Pantoea sp. PSNIH2.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Pantoea.
OX   NCBI_TaxID=1484157 {ECO:0000313|EMBL:AIX75393.1, ECO:0000313|Proteomes:UP000030310};
RN   [1] {ECO:0000313|EMBL:AIX75393.1, ECO:0000313|Proteomes:UP000030310}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PSNIH2 {ECO:0000313|EMBL:AIX75393.1};
RX   PubMed=25232178;
RG   NISC Comparative Sequencing Program;
RA   Conlan S., Thomas P.J., Deming C., Park M., Lau A.F., Dekker J.P.,
RA   Snitkin E.S., Clark T.A., Luong K., Song Y., Tsai Y.C., Boitano M.,
RA   Dayal J., Brooks S.Y., Schmidt B., Young A.C., Thomas J.W.,
RA   Bouffard G.G., Blakesley R.W., Mullikin J.C., Korlach J.,
RA   Henderson D.K., Frank K.M., Palmore T.N., Segre J.A.;
RT   "Single-molecule sequencing to track plasmid diversity of hospital-
RT   associated carbapenemase-producing Enterobacteriaceae.";
RL   Sci. Transl. Med. 6:254RA126-254RA126(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP009866; AIX75393.1; -; Genomic_DNA.
DR   RefSeq; WP_038629329.1; NZ_CP009866.1.
DR   EnsemblBacteria; AIX75393; AIX75393; PSNIH2_17595.
DR   KEGG; panp:PSNIH2_17595; -.
DR   KO; K02313; -.
DR   Proteomes; UP000030310; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030310};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030310}.
FT   DOMAIN      164    366       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      375    444       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     172    179       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      326    346       {ECO:0000256|SAM:Coils}.
FT   COILED      444    464       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   467 AA;  52527 MW;  07CCCFB5FD1BD2C7 CRC64;
     MSLSLWQQCL ARLQDELPAT EFSMWIRPLQ AELNDNTLAL YAPNRFVLDW VRDKYLNNIN
     GLLNDFCGAD APQLRFEVGS KPVVQSIPQP AVTSNASFAA PVAASVAPVQ PAARPSWDSV
     PAPAERSWRS NVNAKHNFDN FVEGKSNQLA RAAARQVADN PGGAYNPLFL YGGTGLGKTH
     LLHAVGNGII ARKPNAKVVY MHSERFVQDM VKALQNNAIE EFKRYYRSVD ALLIDDIQFF
     ANKERSQEEF FHTFNALLEG NQQIILTSDR YPKEINGVED RLKSRFGWGL TVAIEPPELE
     TRVAILMKKA DENDIRLPGE VAFFIAKRLR SNVRELEGAL NRVIANANFT GRAITIDFVR
     EALRDLLALQ EKLVTIDNIQ KTVAEYYKIK VADLLSKRRS RSVARPRQMA MAMAKELTNH
     SLPEIGDAFG GRDHTTVLHA CRKIEQLREE SHDIKEDFSN LIRTLSS
//
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