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Database: UniProt
Entry: A0A0A1DQH8_NOCSI
LinkDB: A0A0A1DQH8_NOCSI
Original site: A0A0A1DQH8_NOCSI 
ID   A0A0A1DQH8_NOCSI        Unreviewed;       540 AA.
AC   A0A0A1DQH8;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 2.
DT   05-JUL-2017, entry version 21.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=KR76_00005 {ECO:0000313|EMBL:AIY19604.2}, SAMN05421671_3717
GN   {ECO:0000313|EMBL:SFM84949.1};
OS   Nocardioides simplex (Arthrobacter simplex).
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Pimelobacter.
OX   NCBI_TaxID=2045 {ECO:0000313|EMBL:AIY19604.2, ECO:0000313|Proteomes:UP000030300};
RN   [1] {ECO:0000313|EMBL:AIY19604.2, ECO:0000313|Proteomes:UP000030300}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM Ac-2033D {ECO:0000313|EMBL:AIY19604.2,
RC   ECO:0000313|Proteomes:UP000030300};
RX   PubMed=25573942;
RA   Shtratnikova V.Y., Schelkunov M.I., Pekov Y.A., Fokina V.V.,
RA   Logacheva M.D., Sokolov S.L., Bragin E.Y., Ashapkin V.V., Donova M.V.;
RT   "Complete Genome Sequence of Steroid-Transforming Nocardioides simplex
RT   VKM Ac-2033D.";
RL   Genome Announc. 3:0-0(2015).
RN   [2] {ECO:0000313|EMBL:SFM84949.1, ECO:0000313|Proteomes:UP000183394}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6946 {ECO:0000313|EMBL:SFM84949.1,
RC   ECO:0000313|Proteomes:UP000183394};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP009896; AIY19604.2; -; Genomic_DNA.
DR   EMBL; FOUK01000004; SFM84949.1; -; Genomic_DNA.
DR   EnsemblBacteria; AIY19604; AIY19604; KR76_00005.
DR   KEGG; psim:KR76_00005; -.
DR   KO; K02313; -.
DR   Proteomes; UP000030300; Chromosome.
DR   Proteomes; UP000183394; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030300,
KW   ECO:0000313|Proteomes:UP000183394};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030300}.
FT   DOMAIN      231    359       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      443    512       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     239    246       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   540 AA;  59738 MW;  F8F3965132163F3C CRC64;
     MTGNPDQPQD ETDTPAPDIP PVDPATARLV HEWTAVVGDL QTHQRAWLQA SRPVTLHGTT
     AIVAVPDDFT RKRLEGRLRG ELEDALTERF GHDVQLAVTV DASLRHELGA ESASYDDGPA
     YDPPTYDAPA YERPRAETDG DAIHPDRADR QVAMSTNPPV DTSTPGAPAA AVPPMPGLPD
     LGAASSAGPS TTPAGEARLN PKYTFETFVI GSSNRFPHAA AVAVSEAPGR SYNPLLVYGE
     SGLGKTHLLH AIGHYVRTIY AGSKVRYVSS EEFTNEFINA IRDDRQDRFK RKYRDIDVLL
     IDDIQFLEGK TQTQEEFFHT FNTLHNANKQ IVLTSDRPPK RLEALEDRLR NRFEWGLITD
     VQPPDLETRI AILRKKAAMD RLTAPSDVLE FIASKIQTNI RELEGALIRV TAFANLNRQD
     VDMTLAEIVL KDLIPEGGEP EITASLIIAQ TAAYFGLSID ELTGPSRGRH LVMARQIAMY
     LCRELTGLSL PKIGAQFGNR DHTTVMYAER KINQLLGERR AVFNQVSELT NRVKMQARQS
//
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