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Database: UniProt
Entry: A0A0A1GU99_9LACO
LinkDB: A0A0A1GU99_9LACO
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ID   A0A0A1GU99_9LACO        Unreviewed;       448 AA.
AC   A0A0A1GU99;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378,
GN   ECO:0000313|EMBL:BAP85555.1};
GN   ORFNames=LOOC260_110160 {ECO:0000313|EMBL:BAP85555.1};
OS   Paucilactobacillus hokkaidonensis JCM 18461.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Paucilactobacillus.
OX   NCBI_TaxID=1291742 {ECO:0000313|EMBL:BAP85555.1, ECO:0000313|Proteomes:UP000031620};
RN   [1] {ECO:0000313|EMBL:BAP85555.1, ECO:0000313|Proteomes:UP000031620}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LOOC260 {ECO:0000313|EMBL:BAP85555.1,
RC   ECO:0000313|Proteomes:UP000031620};
RA   Tanizawa Y., Tohno M., Kaminuma E., Nakamura Y., Arita M.;
RT   "Complete genome sequence and analysis of Lactobacillus hokkaidonensis
RT   LOOC260T.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00378,
CC         ECO:0000256|RuleBase:RU004355};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355}.
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DR   EMBL; AP014680; BAP85555.1; -; Genomic_DNA.
DR   RefSeq; WP_041093455.1; NZ_AP014680.1.
DR   AlphaFoldDB; A0A0A1GU99; -.
DR   STRING; 1291742.LOOC260_110160; -.
DR   KEGG; lho:LOOC260_110160; -.
DR   HOGENOM; CLU_023625_3_1_9; -.
DR   Proteomes; UP000031620; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   NCBIfam; TIGR00237; xseA; 1.
DR   PANTHER; PTHR30008; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR   PANTHER; PTHR30008:SF0; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00378};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW   Rule:MF_00378};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00378};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00378}.
FT   DOMAIN          7..102
FT                   /note="OB-fold nucleic acid binding"
FT                   /evidence="ECO:0000259|Pfam:PF13742"
FT   DOMAIN          128..437
FT                   /note="Exonuclease VII large subunit C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02601"
FT   COILED          272..300
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   448 AA;  50401 MW;  62FF973343C30800 CRC64;
     MDNDKYLTVS ALTKYIKRKF DVDPYLGRIY MTGEISNFRP RANAHQYFSL KDDHAKISAI
     MFKSAFAKIK FQPEEGMKVL VSGRIGLYEA SGSYQIYVDS MQPDGIGALY QAYEQLKRKL
     EQEGLFSAPK QALPMFPKKI AIVTSPSGAV IRDIITTTKR RFPIVQLVLF PAVVQGDAAA
     KDITRQIERV NENGTFDTLI IGRGGGSIED LWPFNEEIVA RAIADSEVPI ISSVGHETDT
     TIADLVADVR AATPTAAAEL AVPVLTDELL KISQQRQRLN NAMKNRIRLA QQDLDKLNQS
     YIFTQPKRLY EGYLQNVDLV TDRLKRQISV SLQKWQQQVS LASSGLSAYS IKQRVNLADK
     QVADLHQRLE QNGQRLVHDR KNVLQNTIAA LDFLSPLKIM SRGYTYVTYD DQVVKSVTEL
     DKGTQVKLHF QDGQADAEIK KITINEEQ
//
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