ID A0A0A1H5Y9_9BURK Unreviewed; 981 AA.
AC A0A0A1H5Y9;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Diguanylate cyclase DosC {ECO:0000256|ARBA:ARBA00015125};
DE AltName: Full=Direct oxygen-sensing cyclase {ECO:0000256|ARBA:ARBA00029839};
GN ORFNames=E1O_15230 {ECO:0000313|EMBL:BAP88654.1};
OS Burkholderiales bacterium GJ-E10.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales.
OX NCBI_TaxID=1469502 {ECO:0000313|EMBL:BAP88654.1, ECO:0000313|Proteomes:UP000031649};
RN [1] {ECO:0000313|EMBL:BAP88654.1, ECO:0000313|Proteomes:UP000031649}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GJ-E10 {ECO:0000313|EMBL:BAP88654.1,
RC ECO:0000313|Proteomes:UP000031649};
RA Fukushima J., Tojo F., Asano R., Kobayashi Y., Shimura Y., Okano K.,
RA Miyata N.;
RT "Complete Genome Sequence of the Unclassified Iron-Oxidizing,
RT Chemolithoautotrophic Burkholderiales bacterium GJ-E10 Isolated from Acid
RT River.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the hemerythrin family.
CC {ECO:0000256|ARBA:ARBA00010587}.
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DR EMBL; AP014683; BAP88654.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A1H5Y9; -.
DR STRING; 1469502.E1O_15230; -.
DR KEGG; bbag:E1O_15230; -.
DR HOGENOM; CLU_303427_0_0_4; -.
DR Proteomes; UP000031649; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd14759; GS_GGDEF_2; 1.
DR CDD; cd12107; Hemerythrin; 1.
DR Gene3D; 3.30.450.40; -; 2.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 1.10.490.10; Globins; 1.
DR Gene3D; 1.20.120.50; Hemerythrin-like; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR044398; Globin-sensor_dom.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR012312; Hemerythrin-like.
DR InterPro; IPR035938; Hemerythrin-like_sf.
DR InterPro; IPR012827; Hemerythrin_metal-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR02481; hemeryth_dom; 1.
DR PANTHER; PTHR46663; DIGUANYLATE CYCLASE DGCT-RELATED; 1.
DR PANTHER; PTHR46663:SF2; GGDEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF01814; Hemerythrin; 1.
DR Pfam; PF11563; Protoglobin; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR SUPFAM; SSF46458; Globin-like; 1.
DR SUPFAM; SSF47188; Hemerythrin-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000031649}.
FT DOMAIN 415..554
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 891..981
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 981 AA; 109305 MW; 7FF57E35B38F7EA8 CRC64;
MPKERSEHSS GHGTVPRQAV LLDQARLLDW DDAMATGIAA VDAEHRQLLD IFRRIAGAGE
MSPEAIAGFL DELGDYSRSH FREEERLMQS GRVSPEHRAM HLQAHAQFAD FLRRTRSLIG
HFLGGVRTEL LAFLAQWLLY HIMEVDQAMA REVRSGQGGA EVVNGAGAPR GNARLQISRL
LGELSDGLGE KTLDLLTQQK KLLDLQALHR ALLQSADVLI HNWNEQDILD SLCRRLTQEA
LFRAVWIGRP GDSGIFDVLA LAGEGADQVR KSPPRLADGD TVSVAARAWN RHGVVVCNDT
LSDDTLRPWH AEFAVHGWHS VLAIPVARAG QMWAILVFAS SRPGCFDAQT VEVCSRIGAL
LGYGLDEFDL KRRIRFLQER DARMARTDAL TGLPNRFALE EYLPQAIARA LRRGKSLAVG
MMDLDDFKPI NDQLGHEAGD DLLRRVSQSL LDLLRDSDFI ARLGGDEFVV VLEDLDSGQE
LAQLTMALTR LHRAVETPFA LGAESEHVVS IDMSMGVALY PNDGIQAELL LRHADAAMYQ
AKQRKRDRAR WWALGAAPAL EQREETSFDA FGDEAQELMR TLAPHLNVLA GKFTVMFYQQ
LEAQSGCESI LASLSADELQ LLKRKQASHL RFLLDPLATE DEVRAAAQRL GTVHGLIGVT
GAWMTWAVGM YRDLLRTHLD GMLFTARTRY RILRAADIRL QRDLESQLHA MQNVLEQYQA
LLARPIGGRT LATDWIAEEL DALAALPGMC VALVWRPDPK NWLVVERASG GRADALVEAF
RVQDLYPTLD PRDARGRGLV ATTWRSDSQQ ETGNFSAEAC ARPWQELMKQ FGIRSAATIP
IHQRDTIHAV LMLFGTYPNQ FSPGWMRTWR MSLQHRWDAM AAAWHRGRAI DKAEAANIRA
LLYGGGLEMF VQPVVDLVDG ALVKVEGLAR LRTPEGGILT PDRFLPALGD TDLDSLFRQG
LTQGLDHLRR WRDQGMDLGL S
//
