ID A0A0A1SSG4_9HYPO Unreviewed; 4345 AA.
AC A0A0A1SSG4;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=VHEMI03410 {ECO:0000313|EMBL:CEJ84200.1};
OS [Torrubiella] hemipterigena.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC Clavicipitaceae incertae sedis; 'Torrubiella' clade.
OX NCBI_TaxID=1531966 {ECO:0000313|EMBL:CEJ84200.1, ECO:0000313|Proteomes:UP000039046};
RN [1] {ECO:0000313|EMBL:CEJ84200.1, ECO:0000313|Proteomes:UP000039046}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Horn F., Habel A., Scharf D.H., Dworschak J., Brakhage A.A., Guthke R.,
RA Hertweck C., Linde J.;
RT "Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus
RT Verticillium hemipterigenum.";
RL Genome Announc. 3:e01439-e01414(2015).
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; CDHN01000002; CEJ84200.1; -; Genomic_DNA.
DR STRING; 1531966.A0A0A1SSG4; -.
DR HOGENOM; CLU_000038_7_0_1; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000039046; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000039046}.
FT DOMAIN 1938..2076
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2593..2748
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2935..3101
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1638..1665
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3197..3259
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3423..3464
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4345 AA; 492242 MW; ADE79C5C715637D7 CRC64;
MEVTSATTPT MPPNGLSTPP FATIEPERVV EHLASICEIA LGASRSELEQ PGNLLNEARY
AETVARCTRF ANDAQNVLYI QKDIASSSNA DSGSDGQSPL SFTYTLTTEI SSSATTFASL
VLLKSPQPID PNRPLSSQIF ITNLPGPAAL SAAVGEQGSA LSPWEVLHSQ VHHALVPYFD
ASTKSQQLAN GLRGRSDVDA KTGIPVTKKR LNDLELSLLH LQQNVDIPEI SLSFHSVVQN
ALEDAESRHS RPSIDSIPQA LLQDSSFLNR LQANVNTWIK SIQGITKMTK DPSSTSNQEF
STASQEVNFW LSMESALEGI EGQLRSEGVL LTLEILKHAK RFQATVSFTA DTGLKEAMEK
VQKYNQLMRD FPLDELLSAT SLPKVQEAIA QIFSHLNKKL RICPYPIRRA LPLVEAISAD
LDDVLHRLLP GTELVNLDYQ QFQSIMRTCD GIFRTWEENI KEFTNVAREV TRRRNEKFIP
IKINKKHSEL ESRIKYVGTF RDNHEQLQRT IVNVLGPKAS IAAVAEAPAT MNNGAVVEEI
GDVDAVEEVQ QAWEALQNVD LLDVTETGKE RWVQAENLYN ERTTRVENSI IARLRDRLAT
AKTANEMFRV FSKFNALFVR PKIRGAIQEY QNQLMDHVKQ AINGLHERFK QQYGHSEAHA
MAQLRDLPPV SGAIIWARQI EFQLDGYMRK VEAVLGPDWN LHAEGRKLQE ESELFKKKLD
TRRIYEAWLT DVNRRKISIT GQLFDIARVR SAGGILELTV NFDPQIITLF KETRNLTWQS
YSVPHAVTTV SKDAKRVYPY AVSLMESVRT LSQTLRQMNS MGPEAVLLNG YRNDVYKLVG
DGVPLRWESF INSHELFYTD QRQNRPMLPG ANDYGLAKNA ESKHGMFIRG FAAAVSVLQS
KTVALGYIHT TIEQALKEII SCPYEPQAFQ SRLDTIQAAV DQLNLEQYVN LDFWVNGLNE
KIQATLLERL QGAIQAWITV FEDETSDNTR RKPTTEDGTK IEGPTMKRLV LEIAMRNQVI
YLEPPMEYAR ASWFLHLHEW LGIVCNLSKI KAARYQMSLN TMPTEEARFT DLPSQCAKTL
QRVYVSVENK LQEIGAYVDK WLQFQSLWDL QSEQVYDMLG DHLPRWLECL QDIRKVRTTF
DTQEVSRSFG HITIDYDQVQ TKVNAKYDQW QQEILMKFAG RLGTRMREVN ADIEKARKSL
EGQSSDTSST AQAVQFITAV QSCKRNVKLW APEIEMFRQG QSTLVRQRYH FPNDWLHIEQ
IDSQWEALKE ILDKKSRIME EQSDAMRANI VAQDKLVNEK IAEIVAEWNQ EKPVSGTIQP
DVASATLSTF ETRITGLQDD LQQVIRAKEA LDLPGTSDTS LEATLEEVRD FQSVWSNLSI
IWASLHETRD ILWTAVQPRK IRSKIDDLIK STKEMPSRMR QYAAFEHVQG ILRGFLKVNS
ILSDLKSDAI RERHWQKIYK QIRPQKRFSP SSMTLGDVWD LNLVATEAIV KDIIAQAQGE
MALEEFIKQV RETWQNYALE MVNYQNKCRL IRGWDDLFAK CSENLNSLQA MKHSPYYKEF
EEEALSWEDK LNRVHVLFDV WIDVQRQWVY LEGVFTGNAD IKHLLPIESG RFQNINSEFL
TVMKKANKTP YVLDVLNIPN AQKSLERLAE MLNKIQKALG EYLEKERVSF PRFYFVGDED
LLEMIGNSND TLRIAKHFKK MFAGLSGLIM DDETVISGFT SKEGESVTLK KEISLTQTPR
INDWLALLEG GMKSTLAELL AEAIDKYTPI FEAETIDRAA LTAYMEEFPS QIVVLAAQAV
WTTAVEASLT AGGSSLQQLF EREVQILRVI ADTVLDDLSV ILRKKCEQMI TECVHQRDVV
EKLANIKADT PSHHLWQLQM RYVYNPQSDF LDRLHVKMAN AKLNYGFEYL GVPDRLVRTP
LTDRCFLTLT QALCQRLGGS PYGPAGTGKT ESVKALGLQL GRFTLVFCCD DTFDFQAMGR
IFLGICQVGA WGCFDEFNRL EERILSAVSQ QIQNIQLGLK QGSEDESSQI ELIGRQLRVN
QNTGIFITMN PGYAGRSNLP DNLKKLFRSV AMSKPDKELI AEVMLYSQGF NQAKRLSKQA
VPFFDECSKK LSKQAHYDFG LRALKSVLVS SGGLKRARLG DGNLGGEEVV EPEIIVQSIR
ETIAPKLIKA DADVMVTIET DCFPGVQYVP ANLHKLEEAI RTLAAERQLV VTETWMTKIL
QLYQIQNIHH GVMMVGNSGS GKSAAWKLLL DALQKVEGVE GVSHVIDSKV MSKEALYGNL
DSTTREWTDG LFTSILRKIV DNLRGEDSKR HWIVFDGDVD PEWVENLNSV LDDNKLLTLP
NGERLNLPPN VRIMFEVETL KYATLATVSR CGMVWFSEDT VTPEMIVTNY LDTLRNVPFE
DLDEDSVATG QSPAKALAVQ GQVADLLQTY LSTDNFVVQA LEKAQSYNHI MDFTAARVLN
TLFSLLNKAV RDMVEYNAQH SDFPLDPEQV EAFVPKRLLL ALVWAFTGDC PLSDRKAFGD
DICAFATFGS PPLDGTSSLI DFDVTLPKAE WSSWQTQVPT IEVNTHSIIQ TDVVIPTLDT
VRHEDVLYSW LAEHKPLLLC GPPGSGKTMT LFSALRKLPN MEVVGLNFSS ATTPDLLIKT
FEQYCEYKKT LNGVMLSPTQ IGRWLVIFCD EINLPAPDKY GTQRAISFLR QLVEHNGFWR
TSDKSWVTLD RIQFVGACNP PTDAGRTPLG ARFLRHAPLI MVDYPGETSL NQIYGTFNSA
VLKIIPALRG YAEPLTNAMV RFYLESQQRF TPKIQPHYVY SPRELTRWVR GIYEAIKPLE
TLSIEGLVRI WAHEALRLFQ DRLVDEDERK WTDDAVKRIA LKHFPTIEEE KALGGPILFS
NWLSKNYMPV EREQLRDFVK ARLKTFCEEE VDVPLILFND VLEHVLRIDR VFRQPQGHLI
LIGVSGSGKT TLSRFVAWMN GLKVFQIKVH GKYSAEDFDD DLRDVLRRCG CKGEKICFIM
DESNVLDSGF LERMNTLLAN AEVPGLFEGD EYAALMTACK EGAQRQNLHL DSPEELYKWF
TQQIVNNLHV VFTMNPPEDG LSSKAATSPA LFNRCVLNWF GDWSDQALFQ VGHELTQSID
LDNSNWHAPG TIPVAYRGLQ LPPSHRETIV NSMVHIHYSL HRYNDKLLKQ QKKLTFLTPR
HFLDFVGQYV KLYTEKREDL EEQQRHLNVG LEKLRDTVDK VRDLRVSLAE KKTQLEQKDA
EANEKLQRMV ADQREAEQRK NTSLEIQSAL EIQEAEVASR KKVVLEDLAK AEPAVEEAKA
SVSNIKRQHL TEVRSMGNPP SGVRLAMDAV CTLLGHKITD WKAIQGIVRK DDFIASILMF
DNGKQMTKPL RMKMRNEFLS NPDFSFEKVN RASKACGPLV QWVAAQVNYS DILDRVGPLK
EEVTQLEEQA LQTKANAKAI ESNIAELEAS ISTYKTEYAA LISETQAIKA EMSKVQFKVD
RSVRLLDSLS SERTRWEDGS KSFETQISTL VGDVLVAAAF LAYSGLYDQT FRKSMMDDWL
HQLHLSGIQY KSHNPVTEYL SSADERLGWQ ENSLPVDDLC TENAIILKRF NRYPLIIDPS
GRVTEFLQKE CKDRRLTVTS FLDDTFTKQL ESSLRFGNPI LIQDAEHLDP ILNHVLNKEY
QRTGGRVLIQ LGKQEIDFSP SFKLYLTTRD PSAQFAPDIC SRTTFVNFTV TQSSLQTQSL
NDVLKSERPD VDERRSNLIK LQGEFKVHLR QLEKQLLQAL NESRGNILDD DNVIETLETL
KTEAAEISKK MSNTEGVMAE VEAITQQYSV VAKSCSAVFA VLENLHYLNH FYQFSLQYFL
NIFQSVLHGN ENLAKETDHN VRRDMIVKDL FVSTFQRTAL GLLQRDRIAL AMLLAQASPF
KMDKSLIDIV LDNRFEGCDL SSSPGDRDEA FAAARKVSTL KDKLDEVSSE SWDKFFSEEL
AENAVPQIWD ESTNAMDQAL ISLALVKFFR MDRFVPAAER YAIAVFGAEM FDVVEDLSQT
IAQVPPTLPV ALVSSPGFDA SYKVDNLVER NKVKCTNIAM GSNEGLTSAD KAINSAAETG
SWVLIKNVHL APTWLQSLEK RMESLNPHKD FRLFLSMESS PKIPVNLLRA SRVLMYEQPA
GVRANMKDSM SSLSTRATKS PVERARLYLL LCFLHAVVQE RLRYAPTLGW KGFWEFNDSD
YECCAFIADT WIDNVAGNRT NLAPQNMPWD MMRYLVTETY GGKIDDEGDF KLLGSLVDSV
LTPAAYDVDH RLVDGPDTLL VPSGTSMQDF NAWVHKLPER EPPTYLGLPA NAEKLLLVGL
GRNLVDNLRS VTEILDEGEQ LMTDS
//
