ID A0A0A1SYR3_9HYPO Unreviewed; 726 AA.
AC A0A0A1SYR3;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=VHEMI05755 {ECO:0000313|EMBL:CEJ89941.1};
OS [Torrubiella] hemipterigena.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC Clavicipitaceae incertae sedis; 'Torrubiella' clade.
OX NCBI_TaxID=1531966 {ECO:0000313|EMBL:CEJ89941.1, ECO:0000313|Proteomes:UP000039046};
RN [1] {ECO:0000313|EMBL:CEJ89941.1, ECO:0000313|Proteomes:UP000039046}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Horn F., Habel A., Scharf D.H., Dworschak J., Brakhage A.A., Guthke R.,
RA Hertweck C., Linde J.;
RT "Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus
RT Verticillium hemipterigenum.";
RL Genome Announc. 3:e01439-e01414(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; CDHN01000003; CEJ89941.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A1SYR3; -.
DR STRING; 1531966.A0A0A1SYR3; -.
DR HOGENOM; CLU_008213_0_0_1; -.
DR OrthoDB; 1360679at2759; -.
DR Proteomes; UP000039046; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:CEJ89941.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:CEJ89941.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|EMBL:CEJ89941.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000039046}.
FT DOMAIN 286..448
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 502..659
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 683..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..726
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 726 AA; 81784 MW; 8D56CE5C3BAAB57E CRC64;
MVDQGPSDTK IETLPDSAQN YFGSRDFSHL KLKENHQNRP LWIDPIKRTI ILEQFHPYAK
QATEFLITIA EPSSRPAFIH EYCLTANSLY AAVSVGLDTD DIIQYLDQFL KVDIPDTIRS
FIRSCTENCG KVKLVLKANR YYMESVDRVL LDELFNDEII VKLGIGSPFL NVNSTLSNST
DDNVQVASGG LPALSQGTEQ ATSTRVALFD LLTGNDDDDD GEHRAAYAYE IPDEAVEALQ
KRCLDFGFPL LEEYDFRRDS ANPDLDIDLR PQTLIRPYQE TGLGKMFGNG RARSGIIVLP
CGAGKTLVGI TAACTIKKGT IVLCTSSVSA VQWRQEFLKW SNIKPEDITL FTADSKSTFA
GDTGIIVSTY AMMANGQGRS HDSQQMMDFL KDREWGLMIL DEVHVVPANM FRRVTSSIKS
HSKLGLTATL VREDDKISHL NFLIGPKLFE ANWNELSQQG HIAKVQCAEV WCAMPSDFLE
QYQQAPSHTK RTLSTINPEK FQACQYLIEK HEARGDKIIV FSDDLYSLRQ YALKLNKAFI
CGETGQEERL RVLENFQKNP LVNTLFLSKV GDTSLDLPEA TCLIQISSHY GSRRQEAQRL
GRILRAKRRN EEGFNAFFYS LVSKNTQEMV YSARRQAFLV DQGYSFKVST RLAGLSSMPN
LAFSSAEERG QLLKEVMAHS KISTSEQTEA AVGTRISGKP ADKRKRKQNP FFQKIAREEK
RRGRQE
//
