ID A0A0A1TGH0_9HYPO Unreviewed; 483 AA.
AC A0A0A1TGH0;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 22-FEB-2023, entry version 28.
DE RecName: Full=Hsp90 chaperone protein kinase-targeting subunit {ECO:0000256|ARBA:ARBA00031396};
GN ORFNames=VHEMI05208 {ECO:0000313|EMBL:CEJ89363.1};
OS [Torrubiella] hemipterigena.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC Clavicipitaceae incertae sedis; 'Torrubiella' clade.
OX NCBI_TaxID=1531966 {ECO:0000313|EMBL:CEJ89363.1, ECO:0000313|Proteomes:UP000039046};
RN [1] {ECO:0000313|EMBL:CEJ89363.1, ECO:0000313|Proteomes:UP000039046}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Horn F., Habel A., Scharf D.H., Dworschak J., Brakhage A.A., Guthke R.,
RA Hertweck C., Linde J.;
RT "Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus
RT Verticillium hemipterigenum.";
RL Genome Announc. 3:e01439-e01414(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the CDC37 family.
CC {ECO:0000256|ARBA:ARBA00006222}.
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DR EMBL; CDHN01000002; CEJ89363.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A1TGH0; -.
DR STRING; 1531966.A0A0A1TGH0; -.
DR HOGENOM; CLU_033261_0_0_1; -.
DR OrthoDB; 1329460at2759; -.
DR Proteomes; UP000039046; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR Gene3D; 1.20.58.610; Cdc37, Hsp90 binding domain; 1.
DR InterPro; IPR004918; Cdc37.
DR InterPro; IPR013873; Cdc37_C.
DR InterPro; IPR013874; Cdc37_Hsp90-bd.
DR InterPro; IPR038189; Cdc37_Hsp90-bd_sf.
DR InterPro; IPR013855; Cdc37_N_dom.
DR PANTHER; PTHR12800; CDC37-RELATED; 1.
DR PANTHER; PTHR12800:SF4; HSP90 CO-CHAPERONE CDC37; 1.
DR Pfam; PF08564; CDC37_C; 1.
DR Pfam; PF08565; CDC37_M; 1.
DR Pfam; PF03234; CDC37_N; 1.
DR SMART; SM01069; CDC37_C; 1.
DR SMART; SM01070; CDC37_M; 1.
DR SMART; SM01071; CDC37_N; 1.
DR SUPFAM; SSF101391; Hsp90 co-chaperone CDC37; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000039046}.
FT DOMAIN 2..194
FT /note="Cdc37 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01071"
FT DOMAIN 197..367
FT /note="Cdc37 Hsp90 binding"
FT /evidence="ECO:0000259|SMART:SM01070"
FT DOMAIN 382..482
FT /note="Cdc37 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01069"
FT REGION 176..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 53078 MW; 8A58E65E7A914DB7 CRC64;
MPVDYSKWDA LELSDDSDVE VHPNVDKRSF IRAKQNQIHQ ERQQRKTKIE ALKYELVLHE
GLRKRVSALL SSLKARADQA ATKNPAEVAF AAVMESAGQQ TDDKLPPLPE GLHTDPNQPK
TYSAMLAGML DQVNKALDEK KPDDRYSSMV AEVESHEGQI NTLLKDSAAE LQKLEQEDKR
KITSDSIHTG FDSSHVNKTT SSAESTKVEL LNPSFDTSGG SSSKKSQSAG GAASAADDDD
EDAEASPAGI KFSQIASNNY SASLDFLSKN PQILTEKETD GLLVLAFDAA LERKDDLCRQ
CVHQALLLQY CRALGKDGVA LFFKRVTTQG HQAQDLFIRD VQDTYMRIKN RAAEIVAERA
NEPEGVEQIQ LHAVEPGTVI NISIPPADSE DTEIKRAREI FEGFAPEMKA ALETGELDKV
NKVLGEMSVE DAEELVNLFS EANILSMEEQ IIDATTEQGK QQLKEIERAA AAAEDEGPTP
DPE
//
