GenomeNet

Database: UniProt
Entry: A0A0A1TXA9_ENTIV
LinkDB: A0A0A1TXA9_ENTIV
Original site: A0A0A1TXA9_ENTIV 
ID   A0A0A1TXA9_ENTIV        Unreviewed;       750 AA.
AC   A0A0A1TXA9;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   08-NOV-2023, entry version 40.
DE   RecName: Full=methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00012838};
DE            EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
DE   AltName: Full=Methionyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030904};
GN   ORFNames=EIN_134970 {ECO:0000313|EMBL:ELP85913.1};
OS   Entamoeba invadens IP1.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP85913.1, ECO:0000313|Proteomes:UP000014680};
RN   [1] {ECO:0000313|EMBL:ELP85913.1, ECO:0000313|Proteomes:UP000014680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP1 {ECO:0000313|EMBL:ELP85913.1,
RC   ECO:0000313|Proteomes:UP000014680};
RA   Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-
CC         methionyl-tRNA(Met); Xref=Rhea:RHEA:13481, Rhea:RHEA-COMP:9667,
CC         Rhea:RHEA-COMP:9698, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:57844, ChEBI:CHEBI:78442, ChEBI:CHEBI:78530,
CC         ChEBI:CHEBI:456215; EC=6.1.1.10;
CC         Evidence={ECO:0000256|ARBA:ARBA00001234};
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363039}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB207027; ELP85913.1; -; Genomic_DNA.
DR   RefSeq; XP_004185259.1; XM_004185211.1.
DR   AlphaFoldDB; A0A0A1TXA9; -.
DR   EnsemblProtists; ELP85913; ELP85913; EIN_134970.
DR   GeneID; 14884920; -.
DR   KEGG; eiv:EIN_134970; -.
DR   VEuPathDB; AmoebaDB:EIN_134970; -.
DR   OrthoDB; 1341752at2759; -.
DR   Proteomes; UP000014680; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd07957; Anticodon_Ia_Met; 1.
DR   CDD; cd00814; MetRS_core; 1.
DR   CDD; cd02153; tRNA_bindingDomain; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 2.20.28.20; Methionyl-tRNA synthetase, Zn-domain; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   HAMAP; MF_00098; Met_tRNA_synth_type1; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR041872; Anticodon_Met.
DR   InterPro; IPR023458; Met-tRNA_ligase_1.
DR   InterPro; IPR014758; Met-tRNA_synth.
DR   InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR   InterPro; IPR033911; MetRS_core.
DR   InterPro; IPR029038; MetRS_Zn.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR002547; tRNA-bd_dom.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   NCBIfam; TIGR00398; metG; 1.
DR   PANTHER; PTHR45765; METHIONINE--TRNA LIGASE; 1.
DR   PANTHER; PTHR45765:SF1; METHIONINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR   Pfam; PF19303; Anticodon_3; 1.
DR   Pfam; PF09334; tRNA-synt_1g; 1.
DR   Pfam; PF01588; tRNA_bind; 1.
DR   PRINTS; PR01041; TRNASYNTHMET.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF57770; Methionyl-tRNA synthetase (MetRS), Zn-domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
DR   PROSITE; PS50886; TRBD; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363039};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363039};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363039};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014680};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU00209};
KW   tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|PROSITE-
KW   ProRule:PRU00209}.
FT   DOMAIN          590..693
FT                   /note="TRNA-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50886"
SQ   SEQUENCE   750 AA;  84700 MW;  495A2B6268598AF1 CRC64;
     MSLPIPVPKV GERNILITSA LPYCNNYPHL GTLIGCVLSA DVYARYCRLK GYNTMFVCGT
     DEYGTTTEQK AIQEHCTPQE ICDKYYKLHK EVYDWFDIAF NYFGRTSTEK QTEITQDIFN
     HLNDNHYIYK EAVEQFFCEK CERFLADRFV EGVCPYCHSV GARGDQCDAC QKLINTVELI
     DPHCKICKTV PIRKSSEHLF IDLPKISDKL DTWANETMEK YEWPNNCSCA TKAWLGNLKG
     RCITRDLKWG TKVPMEGFEN KVFYVWFDAP IGYLSITANY TDDWKKWWMD NEHVELTQFL
     GKDNIVFHSV IFPSTLLGSG MPWTMVRKLA TTEYLNYEDC KFSKSNGTGV FGDDAMKTGI
     PAEVWRYYLL MNRPEQSDTI FLWTDLMEKN NNELLKNLGN LAQRTLTFSN KNFDGKIPRK
     IIKMLDVENK AIEEINGLYE QYTKAMENVK LKEGVKLAMA ISSVGNKYLQ DTTAWTVIKT
     DKERAADVTY FALNILYFVS LVLDPYIPEF GQKVRKQLGV AMMDFPAKFG LILEGNTTLG
     EIGVLFHAIT IDQINKFKEQ FGGIKGEAPK EAKPTVNEKK KQANVKEVLD GFQLDIRVGQ
     IVEAGPHPNS EHLLALKVNV GDEKPRSIVA GLAEFYKPEE LQGKKAVFVC NLKASKLRGV
     ASEGMILAAT SLDGKSVKFC HPTEDIEIGK RVVPSEGKVT ISVKPIVIDV VGKMKLSLKG
     GNVLTDVTPL IVEGTGVKVT VDDVVDGTVR
//
DBGET integrated database retrieval system