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Database: UniProt
Entry: A0A0A1U3V4_ENTIV
LinkDB: A0A0A1U3V4_ENTIV
Original site: A0A0A1U3V4_ENTIV 
ID   A0A0A1U3V4_ENTIV        Unreviewed;       809 AA.
AC   A0A0A1U3V4;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   05-JUL-2017, entry version 15.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=EIN_474330 {ECO:0000313|EMBL:ELP88841.1};
OS   Entamoeba invadens IP1.
OC   Eukaryota; Amoebozoa; Archamoebae; Entamoebidae; Entamoeba.
OX   NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP88841.1, ECO:0000313|Proteomes:UP000014680};
RN   [1] {ECO:0000313|EMBL:ELP88841.1, ECO:0000313|Proteomes:UP000014680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP1 {ECO:0000313|EMBL:ELP88841.1,
RC   ECO:0000313|Proteomes:UP000014680};
RA   Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KB206689; ELP88841.1; -; Genomic_DNA.
DR   RefSeq; XP_004255612.1; XM_004255564.1.
DR   EnsemblProtists; ELP88841; ELP88841; EIN_474330.
DR   GeneID; 14887893; -.
DR   KEGG; eiv:EIN_474330; -.
DR   EuPathDB; AmoebaDB:EIN_474330; -.
DR   KO; K02154; -.
DR   Proteomes; UP000014680; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000014680};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Hydrolase {ECO:0000313|EMBL:ELP88841.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014680};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    379    404       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    425    449       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    500    521       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    533    555       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    596    618       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    730    759       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       93    134       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   809 AA;  93829 MW;  CEDB1C7EAF28619D CRC64;
     MGELIRSQLV SYGQLIVPMS VAEETIQLIG ELNCVQFVDL NSTELSFNRR YCNELKRCDE
     LERKMRYFNE MITKEEERPD FGGLKFQRIS EVFDTEREST ENLELRMESL EKELKQIESD
     CTINENELEK LEEGLLVSSN MDNLFENMAD ISVGGLKYVI GVVEKTKYDA IQRLIWRISR
     GLVLIKSTDL SENSNLRNFL VLFQGDDLEV RITKSCQSLG VRMYTKVPLD QLERRNFVEE
     ALNSKQTLSE LFEGSTKQKR ELLKKIAIKL EDWKETVTRE KLIYFTLNMF RVDRGQTLTG
     ECWYPSARFD DIVQKLGQLD QSNMSPVFTP IPPHPKAIVP TFNKTNSFTQ TFQDLTDSYG
     TPHYGEINTA WLNIVTFPWL FGVMFSDCGH GFFIFLFGLS FIIFAKKLQG KAMNDIFVML
     FDARYLLMLM GLYSMYCGCL FNEFFGFSID FFGTAWDVKN ESKGVYERSD NGYIYYFGVD
     PIWKSSNNEL YYLNSLKMKL SILIGVFHMI FGIILSLFNY IHMKKYINIW FHWIPEMIFM
     ICSFGYLCFL IIFKWCAPFQ EGAPMLTNVF LEMFQNFGIV TEENHIYSGQ EVIEPILLVL
     VIISLILMFV PKPAILYYRL RKHQKALPEC RPLLSEGGNT EESMFEDNMV PPATDTDSLI
     FQVKEEKKES GEEEEEDNEE GNSLMEIIIF NSIHGIEFVL GCISNTASYL RLWALSLAHA
     ELSAVFLENV FYLLLGMKIC VTIFVGFAVW AMITLAILIG MESLSAFLHT LRLHWIEFQN
     KFYVGDGVPF TPIKLEPRKS FFDQVDSRQ
//
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