ID A0A0A1U510_ENTIV Unreviewed; 344 AA.
AC A0A0A1U510;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=RNA uridylyltransferase {ECO:0000256|ARBA:ARBA00012472};
DE EC=2.7.7.52 {ECO:0000256|ARBA:ARBA00012472};
GN ORFNames=EIN_487910 {ECO:0000313|EMBL:ELP89279.1};
OS Entamoeba invadens IP1.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP89279.1, ECO:0000313|Proteomes:UP000014680};
RN [1] {ECO:0000313|EMBL:ELP89279.1, ECO:0000313|Proteomes:UP000014680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP1 {ECO:0000313|EMBL:ELP89279.1,
RC ECO:0000313|Proteomes:UP000014680};
RA Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide;
CC Xref=Rhea:RHEA:14785, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17348,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:140395,
CC ChEBI:CHEBI:173116; EC=2.7.7.52;
CC Evidence={ECO:0000256|ARBA:ARBA00024498};
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DR EMBL; KB206670; ELP89279.1; -; Genomic_DNA.
DR RefSeq; XP_004256050.1; XM_004256002.1.
DR AlphaFoldDB; A0A0A1U510; -.
DR EnsemblProtists; ELP89279; ELP89279; EIN_487910.
DR GeneID; 14888235; -.
DR KEGG; eiv:EIN_487910; -.
DR VEuPathDB; AmoebaDB:EIN_487910; -.
DR OrthoDB; 21395at2759; -.
DR Proteomes; UP000014680; Unassembled WGS sequence.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:InterPro.
DR GO; GO:0050265; F:RNA uridylyltransferase activity; IEA:RHEA.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:UniProt.
DR GO; GO:0061157; P:mRNA destabilization; IEA:UniProt.
DR CDD; cd05402; NT_PAP_TUTase; 1.
DR Gene3D; 1.10.1410.10; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002058; PAP_assoc.
DR InterPro; IPR045862; Trf4-like.
DR InterPro; IPR045100; TUTase_dom.
DR PANTHER; PTHR23092:SF15; INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED; 1.
DR PANTHER; PTHR23092; POLY(A) RNA POLYMERASE; 1.
DR Pfam; PF03828; PAP_assoc; 1.
DR Pfam; PF19088; TUTase; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE 4: Predicted;
KW Nucleotidyltransferase {ECO:0000313|EMBL:ELP89279.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000014680};
KW Transferase {ECO:0000313|EMBL:ELP89279.1}.
FT DOMAIN 22..122
FT /note="TUTase nucleotidyltransferase"
FT /evidence="ECO:0000259|Pfam:PF19088"
FT DOMAIN 199..252
FT /note="PAP-associated"
FT /evidence="ECO:0000259|Pfam:PF03828"
FT REGION 312..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 344 AA; 38908 MW; 1E67E97A447DF564 CRC64;
MWLRSVCPTD KLTLTEEIKL FTRYISLTPN EQELRQISYQ KVSQLLTNRY PGCEVTIYGS
YVSGFSLPSS DIDLVLSFSE EVSKNQVKKL LFKISTICRS SKFLRVEDVI TNAKVPIIKL
LDLDTTISID LSINCEGGID SSALTHSLLT SSQFTQEIAL FVKYLVFQNN LNEPYHGGIG
SYAIVLLTAT FLKFYPQHSL GRALVEFLNF YGNIFKMGKT GVSYQHGFFS LVEKNLFEED
SLVIEDPCDE GNNVGRSSFK FNAVQFLFKK TLMGINLIIK NPEGMYLPSG SRLAKVVAIP
KSLQKYREAI DAVKSEQKSE EKTEEKEEVE VMKSPEIYNE PLVQ
//
