ID A0A0A1UCQ4_ENTIV Unreviewed; 346 AA.
AC A0A0A1UCQ4;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 08-NOV-2023, entry version 26.
DE RecName: Full=Sphingomyelin synthase-like domain-containing protein {ECO:0000259|Pfam:PF14360};
GN ORFNames=EIN_404780 {ECO:0000313|EMBL:ELP90074.1};
OS Entamoeba invadens IP1.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP90074.1, ECO:0000313|Proteomes:UP000014680};
RN [1] {ECO:0000313|EMBL:ELP90074.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP1 {ECO:0000313|EMBL:ELP90074.1};
RA Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR EMBL; KB206537; ELP90074.1; -; Genomic_DNA.
DR RefSeq; XP_004256845.1; XM_004256797.1.
DR AlphaFoldDB; A0A0A1UCQ4; -.
DR EnsemblProtists; ELP90074; ELP90074; EIN_404780.
DR GeneID; 14889003; -.
DR KEGG; eiv:EIN_404780; -.
DR VEuPathDB; AmoebaDB:EIN_404780; -.
DR OrthoDB; 22880at2759; -.
DR Proteomes; UP000014680; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF25; SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014680};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 209..300
FT /note="Sphingomyelin synthase-like"
FT /evidence="ECO:0000259|Pfam:PF14360"
SQ SEQUENCE 346 AA; 39980 MW; DCC451D00FA847E6 CRC64;
METDTQTNPP NPVNPTPSNV TTEICLLLPN CNFPARGIYA LKDTFEELFR MGKQFVKSPL
QQTMKFLVHP FFWSLVFMII CGYWNGIFQV LTQKRFERWV KTHPQATDEI VIADVAFDVL
PVLSISELPE TLSMIFIITT LIRFFLTPYR FVILRRYFFL QGVIYFIRGL CVFTTILPDP
SGRKSTVNTN NILLEGFLVL LGVHRIECDM MFSGNAASMV ICACLWHHYS HRAPIFDFDI
LGSTPSSTPY GYPLRMTIVK FAMWGFTLIC FVLYIMNRMH YIADIYIGFV FSLFLFKLYH
NYILFCAIRN NFVNSFVKWF ESDAMDIPAV VRVPMEGISS SDAMSN
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