ID   A0A0A1UU12_9HYPO        Unreviewed;      1528 AA.
AC   A0A0A1UU12;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   22-FEB-2023, entry version 25.
DE   SubName: Full=NACHT and HEAT repeat domain protein {ECO:0000313|EMBL:EXV00837.1};
GN   ORFNames=X797_005850 {ECO:0000313|EMBL:EXV00837.1};
OS   Metarhizium robertsii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=568076 {ECO:0000313|EMBL:EXV00837.1, ECO:0000313|Proteomes:UP000030151};
RN   [1] {ECO:0000313|EMBL:EXV00837.1, ECO:0000313|Proteomes:UP000030151}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 2575 {ECO:0000313|EMBL:EXV00837.1,
RC   ECO:0000313|Proteomes:UP000030151};
RA   Giuliano Garisto Donzelli B., Roe B.A., Macmil S.L., Krasnoff S.B.,
RA   Gibson D.M.;
RT   "The genome sequence of the entomopathogenic fungus Metarhizium robertsii
RT   ARSEF 2575.";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EXV00837.1}.
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DR   EMBL; JELW01000010; EXV00837.1; -; Genomic_DNA.
DR   eggNOG; KOG2029; Eukaryota.
DR   HOGENOM; CLU_003175_1_0_1; -.
DR   OrthoDB; 2251579at2759; -.
DR   Proteomes; UP000030151; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46844; SLR5058 PROTEIN; 1.
DR   PANTHER; PTHR46844:SF1; SLR5058 PROTEIN; 1.
DR   Pfam; PF13646; HEAT_2; 2.
DR   Pfam; PF05729; NACHT; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        156..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          444..584
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1528 AA;  172678 MW;  3DF574B9BB6A1A3E CRC64;
     MDRLRSRRDA RALATLPGQS RGHASHERIQ DTKLNPAREH TTGVTLTQIH PLPGVDVETD
     IDIIAIHGLD TGSPGTWTWK FNRPDRHDVN WLADKDMLPS RVGQARILTC DWPAELFERS
     DLIQKRIEEL ARLLLDGIRR RPSATNTSSK RGGRPIVFIA SCLGGIILMK ALVMAQYESC
     SIGGSSGSDT HAIIFLATPF RGTSFQDVAN WAEPGLKAWA WIRGQKVTRR LDDVKGPTFD
     LVKLVGDFTR LCREDSLDRV MTFYELGNTN LYHKVFPCLL VGSKRLVDES SAILDIVPNP
     LPLDRPHLTM NKFHGTDDPE YQKVAGKLEE FLHGIREGTV LNIADAWIRN QCYAADRLQI
     RRLSEEELPM EQCYINLAII EQQCGRVSSG SGYGSNGAYS TSQSYPFSMI SRQKVQTPDK
     SIQVELKTLF DQRGRGDHGV IKPRRILIRG RAGVGKTTLC KKMVYDFIQQ TSLHDLWTQW
     FDRLLWVPLR NLQRRPGQGY NLSLLFRDEY FRHHLGMGGL TREDLAAELS RKVDDSKSER
     TLFVLDGLDE VSQLLASSNE MSDFLKMLLN KPNVIVTSRP NASLPAIRTF DLELETIGFY
     PDQVREYIEK SFVDPDTKTT DLNKLKSFQS FLQNHQLIQD LVRIPILLDA LCYTWNDHKP
     GNIPDTMTGI YRLIELKLWK KDILRLEKRH DGAQLFSFNL ETAPRPTIKS FVKEEMDFLE
     SLAFTGLYDN TVDFSLEQIH GISHYFTPGL LPDKTLPSLS FLRTSEASSD YRNQNYHFIH
     QTYQEYFAAR YFVRQWSNPE GRLVLFAQNG GEREMKLSKP VEFLQEHKYA AGYNIFWRFV
     AGLLDAESGV KETLRFFRTI EQEPFDLLGP THQRLVMHCL SEVSNELQIR KDLLARLTQW
     FLFEVYLTNL YARPTLLQEP ECPDEAILAA LELVSDSGRE NILRAVHKYL PHTTITALIA
     LLKDEHETRF PAAAVLKDQS NLSDQAIVSL LALLEHEKEE VQFAAAEVLR IQSDLSDTAI
     ASLSALLEHE QDTTRTAAAE ALRSQSHLSD TAIVSLLALL EHGQDTTQTA AAEVLKSQSH
     LSDITIASLL ALLEHKKDTT RSAAAKTLKS QWKLSDAAIG SLSALLEHEE ENVRFAAAKA
     LPRRAPATMI ISLIVRLRHK EQRVRSVAAK ALGTCTQRRY LKTVVEPLET LLQSQDYNDK
     MAAVEALHLS YGLSDATIVS LIALLKDESL PAQSVAAKAL KSQSHLSDTA IVSLLALLEH
     EREEIRSVAV EVLSRQALPD AAIKTLTVLL QSNDGVLRAA AAKILTSQKD LPDAVIESLL
     MLLQSENYGA KTDIVRAWCF RASRLQRNIP HVENLMKAQF RKFDPWTTAV ILTAWNSQPN
     LSNAAIESLI ALFQARKRDD QAWLAEYMGL CPNLMDKMLK TILKTLGLLL ETELPAEPIN
     SIFRNSQFLK LVYGILLYES FRSHNSLYVQ SDGGSSRCIF NQPAGRRIAS FEESSVADEF
     HKLLSDCQKY WNEHGFKLWD RFGVDASQ
//