ID A0A0A1VKU4_9BURK Unreviewed; 706 AA.
AC A0A0A1VKU4;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:GAD24335.1};
GN ORFNames=AVS7_04095 {ECO:0000313|EMBL:GAD24335.1};
OS Acidovorax sp. MR-S7.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Acidovorax.
OX NCBI_TaxID=1268622 {ECO:0000313|EMBL:GAD24335.1};
RN [1] {ECO:0000313|EMBL:GAD24335.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MR-S7 {ECO:0000313|EMBL:GAD24335.1};
RX DOI=10.1128/genomeA.00412-13;
RA Miura T., Kusada H., Kamagata Y., Hanada S., Kimura N.;
RT "Genome Sequence of the Multiple-beta-Lactam-Antibiotic-Resistant Bacterium
RT Acidovorax sp. Strain MR-S7.";
RL Genome Announc. 1:e00412-13(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
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DR EMBL; DF238983; GAD24335.1; -; Genomic_DNA.
DR RefSeq; WP_020229836.1; NZ_DF238983.1.
DR AlphaFoldDB; A0A0A1VKU4; -.
DR STRING; 1268622.AVS7_04095; -.
DR eggNOG; COG1250; Bacteria.
DR OrthoDB; 5287258at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000030646; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000030646}.
FT DOMAIN 315..490
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 493..590
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 706 AA; 74647 MW; 1AC1EDC407308DC4 CRC64;
MTDQFPLTLQ EGGIALIRLD AQPGEAGAVC PPQLEALVAA LQTAAERADV QGVLLHASGP
SWLPEAGAQA WLDLCRAGDA HAIAAVLQRR SGLLRAVERL PNPIAIVIEG ACMDLCLEFA
LACHARWAVP GARLGLPLVK RGLPPSAGAT QRLPRLAGIP AVLNGLLAGD TWEADAARQM
GLLSGVQPLA QALQDARAWL LAHPQAQAPW DAKGYRLPGG AGAMAAHAGR SFTDNIARLR
KPSDTQPAPL ALLSAVYEGT QLPIDAALKV EAQCAAQALA EPATANQIRS LWLHQAQARQ
LVRRPADVPE QPVRKLGVLG SGLMGAGIAQ VAAAAGIDVV MVDTSAERAQ AAHGKIAAAL
ARGHGDRAAA IAQRIEPTAD LQRLHGCEFV IEAVFEDRAV KADLMARAAP VLADRPVHFV
WASNTSTLPI GGLASAWAAP EQVIGMHFFS PVPRMPLLEI ILGARTNPAT VARTLDLAAR
LGKTPILVND SSGFYTSRIF CAYIDEGMAM LAEGVNPALI ENAARQAGFA TAPLAVTDEV
SLDLQALVIG QARKDGLEEK FLRTLAQPAV ERMNQLQRLG RKSGGGFYDY PKSGKHLWPG
LAQQFPQSGE QPDLDTVMGR MLCIEAMESA RCLEEGVLTS AADGDLGALL GLGFPAWTGG
TFSYIDTVGC AAFVQRCDVL ADRFGERFRP SAWLRDRAAQ GLRFHP
//