UniProt: A0A0A1YQE7

Database: UniProt
Entry: A0A0A1YQE7_9PSED

LinkDB:  A0A0A1YQE7_9PSED 
Original site:  A0A0A1YQE7_9PSED

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (12)   
   InterPro (8)   
   Pfam (3)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (19)   

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ID   A0A0A1YQE7_9PSED        Unreviewed;       436 AA.
AC   A0A0A1YQE7;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=GDP-mannose 6-dehydrogenase {ECO:0000256|ARBA:ARBA00020994, ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.132 {ECO:0000256|ARBA:ARBA00012932, ECO:0000256|PIRNR:PIRNR000124};
GN   ORFNames=TMS3_0105205 {ECO:0000313|EMBL:KFX71323.1};
OS   Pseudomonas taeanensis MS-3.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=1395571 {ECO:0000313|EMBL:KFX71323.1, ECO:0000313|Proteomes:UP000030063};
RN   [1] {ECO:0000313|EMBL:KFX71323.1, ECO:0000313|Proteomes:UP000030063}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MS-3 {ECO:0000313|EMBL:KFX71323.1,
RC   ECO:0000313|Proteomes:UP000030063};
RX   PubMed=24407626;
RA   Lee S.Y., Kim S.H., Lee D.G., Shin S., Yun S.H., Choi C.W., Chung Y.H.,
RA   Choi J.S., Kahng H.Y., Kim S.I.;
RT   "Draft Genome Sequence of Petroleum Oil-Degrading Marine Bacterium
RT   Pseudomonas taeanensis Strain MS-3, Isolated from a Crude Oil-Contaminated
RT   Seashore.";
RL   Genome Announc. 2:0-0(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GDP-alpha-D-mannose + H2O + 2 NAD(+) = GDP-alpha-D-mannuronate
CC         + 3 H(+) + 2 NADH; Xref=Rhea:RHEA:21728, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57527, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:84886; EC=1.1.1.132;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- PATHWAY: Glycan biosynthesis; alginate biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005182, ECO:0000256|PIRNR:PIRNR000124}.
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00006601, ECO:0000256|PIRNR:PIRNR000124}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFX71323.1}.
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DR   EMBL; AWSQ01000001; KFX71323.1; -; Genomic_DNA.
DR   RefSeq; WP_025164165.1; NZ_AWSQ01000001.1.
DR   AlphaFoldDB; A0A0A1YQE7; -.
DR   STRING; 1395571.TMS3_0105205; -.
DR   eggNOG; COG1004; Bacteria.
DR   OrthoDB; 9803238at2; -.
DR   UniPathway; UPA00286; -.
DR   Proteomes; UP000030063; Unassembled WGS sequence.
DR   GO; GO:0047919; F:GDP-mannose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0042121; P:alginic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR028358; GDPman_DH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   NCBIfam; TIGR03026; NDP-sugDHase; 1.
DR   PANTHER; PTHR43750:SF1; GDP-MANNOSE 6-DEHYDROGENASE; 1.
DR   PANTHER; PTHR43750; UDP-GLUCOSE 6-DEHYDROGENASE TUAD; 1.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500135; GDPman_DH; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF52413; UDP-glucose/GDP-mannose dehydrogenase C-terminal domain; 1.
PE   3: Inferred from homology;
KW   Alginate biosynthesis {ECO:0000256|ARBA:ARBA00022841,
KW   ECO:0000256|PIRNR:PIRNR000124};
KW   NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|PIRNR:PIRNR000124};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|PIRNR:PIRNR000124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030063}.
FT   DOMAIN          317..425
FT                   /note="UDP-glucose/GDP-mannose dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00984"
FT   ACT_SITE        268
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-1"
FT   BINDING         10
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         11
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         30
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         35
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         86
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         124
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         161
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         210
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         214
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         217
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         225
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         256
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         257
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         259
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         262
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         265
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         271
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         324
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         331
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
SQ   SEQUENCE   436 AA;  47051 MW;  9355211FF27259BC CRC64;
     MRISIFGLGY VGAVCAGCLS ARGHEVIGVD VSQPKIDLIN QGKSPIVEPG LAELLDAGVK
     AGRLHGTTDV AAAVLASELS FIAVGTPSKR NGDLDLGYME QVCTQIGTAL RDKSERHTIV
     VRSTVLPGTV KNVVIPLIEA ASGKRAGVDF GVATNPEFLR ESTAINDYDF PAMTVIGELD
     VQSGDLLQEL YSELDAPIIR KSIEVAEMIK YTCNVWHATK VSFANEIGNI AKACGVDGRE
     VMDVVCQDHK LNLSRYYLRP GFAFGGSCLP KDVRALTYRA GQMDVEHPLL SSIMPSNRVQ
     VQRAFDMVAS YGKRKVGLLG LSFKAGTDDL RESPLVELAE MLIGKGYELR IFDSNVEYAR
     VFGANKEYIE SKIPHVSSLL CGELEDVVAT SDVLILGNGD SRFADVLMNA GDDKQIVDLV
     GFMQHSTSGS KEGICW
//

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