ID A0A0A2EF60_9PORP Unreviewed; 417 AA.
AC A0A0A2EF60;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Hemolysin {ECO:0000313|EMBL:KGN77491.1};
GN ORFNames=HW49_10860 {ECO:0000313|EMBL:KGN77491.1};
OS Porphyromonadaceae bacterium COT-184 OH4590.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae.
OX NCBI_TaxID=1517682 {ECO:0000313|EMBL:KGN77491.1, ECO:0000313|Proteomes:UP000030107};
RN [1] {ECO:0000313|EMBL:KGN77491.1, ECO:0000313|Proteomes:UP000030107}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COT-184 OH4590 {ECO:0000313|Proteomes:UP000030107};
RA Wallis C., Deusch O., O'Flynn C., Davis I., Jospin G., Darling A.E.,
RA Coil D.A., Alexiev A., Horsfall A., Kirkwood N., Harris S., Eisen J.A.;
RT "Porphyromonadaceae COT-184_OH4590 Genome sequencing.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGN77491.1}.
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DR EMBL; JRAN01000072; KGN77491.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A2EF60; -.
DR eggNOG; COG1253; Bacteria.
DR Proteomes; UP000030107; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR019862; Motility-assoc_prot_GldE.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR NCBIfam; TIGR03520; GldE; 1.
DR PANTHER; PTHR22777; HEMOLYSIN-RELATED; 1.
DR PANTHER; PTHR22777:SF17; UPF0053 INNER MEMBRANE PROTEIN YFJD; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01595; CNNM; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000030107};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 61..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..189
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 205..264
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 269..326
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 417 AA; 47284 MW; CD1D7E1D0B4EE4AB CRC64;
MNALGILMII LGLLIISAFN SAAETAFFSF SPNNLDEIKE ESQDNITYKR ILNLLKNPEK
LLATVLLSND LCNIAVAVLS AIFLTMIVDF GDSFLLEFVI QTIVITFIIL LFAEIIPKIY
ASQNPLKVAS FSATPLTAID KILSPISTLL VKSTSIVHKR LKKNHQTISV DELSQALDLT
NHIEGEQDIL RGIVEFGNLS VDSIMTPRID VVAINIKTLF SDVVKKIIDT GYSRIPVYEK
SLDQIVGVLY IKDLIAHINK GDTFRWQTLI RPATFIPETR KIDDLLLDFQ KHKVHIAIVV
DEFGGTLGII TMEDIMEEII GDIADEYDED NKQYEKIDDK TYEFEGKILL NDFYKILDIS
PDEFDHLTNE VDTLAGLILE MFEEMPHVSE HVSYKNYTFT IIALEKRRIK RIKLEIE
//
