ID A0A0A2F130_9PORP Unreviewed; 1909 AA.
AC A0A0A2F130;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Alpha-2-macroglobulin domain-containing protein {ECO:0000259|SMART:SM01360};
GN ORFNames=HQ41_06700 {ECO:0000313|EMBL:KGN83730.1};
OS Porphyromonas sp. COT-290 OH860.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC Porphyromonas.
OX NCBI_TaxID=1515615 {ECO:0000313|EMBL:KGN83730.1, ECO:0000313|Proteomes:UP000030116};
RN [1] {ECO:0000313|EMBL:KGN83730.1, ECO:0000313|Proteomes:UP000030116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COT-290 OH860 {ECO:0000313|Proteomes:UP000030116};
RA Wallis C., Deusch O., O'Flynn C., Davis I., Jospin G., Darling A.E.,
RA Coil D.A., Alexiev A., Horsfall A., Kirkwood N., Harris S., Eisen J.A.;
RT "Porphyromonas sp. strain:COT-290_OH860 Genome sequencing.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGN83730.1}.
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DR EMBL; JRAR01000057; KGN83730.1; -; Genomic_DNA.
DR RefSeq; WP_044189475.1; NZ_JRAR01000057.1.
DR eggNOG; COG2373; Bacteria.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000030116; Unassembled WGS sequence.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000030116}.
FT DOMAIN 1147..1237
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT COILED 1513..1547
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1909 AA; 218097 MW; 0CC73930314B208F CRC64;
MKRTIGLVYL CVLLCLLGWI RVDAQRTAQY TTQASKLKQE LLQAQKLRQP KTALDKAQSL
MRLAERNRQL SDLLLALVAS RDANRSISTD HDAEVFVQLA RVAQLSWLNP EERSLLSAVT
HSLYEDYQYR SRYYTRRNPM EEGEEYDAID PRRWSDSLYR QKLEALAREA LKDRRVLHQP
MRHELPPSVS RGTSKWNSTL GSYVYQLLVY RSGEISPLIL ASLQAYVQDL PIGAERLHAD
YFLLEHKYKD ASHREKELCR QFLDTYAGQI EVMQYITDIS QKLYEPSEPR LAVELLDRYL
QRFGSKASPT LVRSIREYRS GLLVASLDYE VGTNIVTGHR VQMLRLNHTL VDSVRLKLYH
TPSVLLNLDE QYDPQQLHLE QERTIALLPD SLWGSRSDTL RLEHRHRGLY YLHLEPVRSP
QASSLRKAYH SDRYIRYYVT DQFVINHEAQ GGRGGHLQWL DALSGRPLSA LAVQMKLRKG
TEQKQKTDEQ GRVQLPRPLD GQWYSSVFVR STNLEDPLGL SVGISRDTRE QGKPKGQVEA
LLSTDRPVYR PADTLRLWGY LAEQKAHAEL ARVLPEESIE LILYDANSER IQSIHVTTDS
LGRFDGQFTL PREAKLGRYR IVCERTGRYI ASSNVLVEEY RKPTFEVKMN KAERLLRLGD
SIDLSIRVVD MTGLPLASVR LAPKVQITGR AYQPRYGYFI TMSREQEELN LPELVTDAEG
RAMLRLHLSR LKAFDQLDRA VELYQYYRVG VQVTATTGEV QRGEIRFSIG KDLPQITAKL
PQYMEVNQSK QILEVRVQNS DYEPVPYLAT YEIRSRQKVW LTDTCSSNTE RNLSGQLRNL
PSGAYDLKTR ITLEDGRELS DTTSFVLYRS SDRIIEVKGA PLVATAPELT YSSRRPPLIH
YASALEDSYI YYRTEIDGRV IGYGMLRPRP SSLNQLMIDL PRETTEQVRV YLYTVRSARL
YEQTFTFSRV QPDKELTLSW QSFRDRLRAG SNETWQLRVL HKGKPVRASI AAWMYDSALD
AVMPLRFTQL YAHPLLRPFY THAYGLTNDR FAPNAVGQIN WGASQSEDYD VWHQSFVPLG
SMQEEYGGGN AMLLERSAVP KQMSAEAGAI RSKELRSMML AKSSDITDDA TEASPVEGGL
RQDFAETAFF RPRMLTDKSG EVSWSFQLPD NLTRWRLELV AHTADMNTGY HRAYIESYRE
LMLKPYLPRL IRLGDKLSLA AQVQNLSDRE QAGSVRLELF RLQDQAIIHQ DSLPLKVAPS
QTQDFRFSVA LDQSLELDSI GVRMMAHGSG FADGEQRALP ITSSREEAIR SEAFTLLTAE
QTKVDLSELF PSTGFIPDSG RVEVRVESNP LFLALQTLPT LAQDNLANAI SISSALYGQA
LAKAVAQTPG LQHWLSERRA EMRDSLRDDI DSLLKRPLST TPWAKVIASE DEGKRLASLV
AFFGTLGQSD REDRLLRELA ELQGSDGLWP WFARMRGSLY TTTYVMRQLV RLRQLNPRAV
DTRRTELMLQ RGHQALDKAM AELMQQIQEA ERKSKQIHGQ ISSLELNYLY ILELNKRAKS
ETNVAQRRFF LERLRRGAHE LPLWAKPQAA IALAEYDRPL ALLLVESLRQ HLSDAEVGAF
FAQISTGGYW WINRSYTMVT EMIEALRLLA PEDKATLHSL QQWLLNQKRS VRWESTTATA
EALYALFVGS GSTELREPNR TELTLKRADG TELVQSGERI RLVEDFDRAS YPLAIEARAQ
HSGQVWGAAT ARYMLPSIEE RASGRELQIE RRHYLKAVQG GREKLIPLAT GQSLAVGDVL
VTKLMLKLSR EMDFVALSDP RLGCTEPRRQ TSGYVWHSGA GYYYEPRDMM TNFYFDRLGR
GEYQIEYEQY VVRSGTYQVT SASAQSVYAP EYTATSGFGG TLEVAECRE
//
