ID A0A0A2FF07_9PORP Unreviewed; 306 AA.
AC A0A0A2FF07;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=3-phosphoglycerate dehydrogenase {ECO:0000313|EMBL:KGN88697.1, ECO:0000313|EMBL:SQH73693.1};
DE EC=1.1.1.95 {ECO:0000313|EMBL:SQH73693.1};
GN Name=serA {ECO:0000313|EMBL:SQH73693.1};
GN ORFNames=HQ45_08300 {ECO:0000313|EMBL:KGN88697.1}, NCTC12858_01559
GN {ECO:0000313|EMBL:SQH73693.1};
OS Porphyromonas crevioricanis.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC Porphyromonas.
OX NCBI_TaxID=393921 {ECO:0000313|EMBL:KGN88697.1, ECO:0000313|Proteomes:UP000030139};
RN [1] {ECO:0000313|EMBL:KGN88697.1, ECO:0000313|Proteomes:UP000030139}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COT-253 OH2125 {ECO:0000313|Proteomes:UP000030139}, and
RC COT-253_OH2125 {ECO:0000313|EMBL:KGN88697.1};
RA Wallis C., Deusch O., O'Flynn C., Davis I., Jospin G., Darling A.E.,
RA Coil D.A., Alexiev A., Horsfall A., Kirkwood N., Harris S., Eisen J.A.;
RT "Porphyromonas crevioricanis strain:COT-253_OH2125 Genome sequencing.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SQH73693.1, ECO:0000313|Proteomes:UP000249300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12858 {ECO:0000313|EMBL:SQH73693.1,
RC ECO:0000313|Proteomes:UP000249300};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JQJB01000013; KGN88697.1; -; Genomic_DNA.
DR EMBL; LS483447; SQH73693.1; -; Genomic_DNA.
DR RefSeq; WP_023940233.1; NZ_LS483447.1.
DR AlphaFoldDB; A0A0A2FF07; -.
DR STRING; 393921.HQ45_08300; -.
DR KEGG; pcre:NCTC12858_01559; -.
DR eggNOG; COG1052; Bacteria.
DR OrthoDB; 9777288at2; -.
DR Proteomes; UP000030139; Unassembled WGS sequence.
DR Proteomes; UP000249300; Chromosome 1.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0004617; F:phosphoglycerate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42789; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR PANTHER; PTHR42789:SF1; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000249300}.
FT DOMAIN 21..306
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 126..250
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 306 AA; 33646 MW; AF2572D93A6AFB5C CRC64;
MAKILIATEK PFAPVAVNGI REIIEKAGFE LTLLEKYTEK SQLLNAVADV DAIIVRSDIV
DNEVFDAAKN LKIVVRAGAG YDNVDCAAAT AHNVCVMNTP GQNSNAVAEL CIGMLIYGLR
GMFNGASGNE LKGKKVGILA YGHIGKLVAE YCKAFGCEVY AYHPRRTDEQ IQADGVIPVH
SQQELFEKCQ IVSVHTPSRP ENKGCVNYEC MSKMPAKAII LNSARKEVFN EEDLVRIMKE
RTDMKYLTDI QPACHDKMCE LFEGRYYATP KKMGAQTAEA NINAGLAAAE QIVKFIKNGD
ETFRVN
//
