ID A0A0A2G786_9PORP Unreviewed; 872 AA.
AC A0A0A2G786;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=HQ36_05170 {ECO:0000313|EMBL:KGN98287.1};
OS Porphyromonas gingivicanis.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC Porphyromonas.
OX NCBI_TaxID=266762 {ECO:0000313|EMBL:KGN98287.1, ECO:0000313|Proteomes:UP000030134};
RN [1] {ECO:0000313|EMBL:KGN98287.1, ECO:0000313|Proteomes:UP000030134}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COT-022 OH1391 {ECO:0000313|Proteomes:UP000030134};
RA Wallis C., Deusch O., O'Flynn C., Davis I., Jospin G., Darling A.E.,
RA Coil D.A., Alexiev A., Horsfall A., Kirkwood N., Harris S., Eisen J.A.;
RT "Porphyromonas gingivicanis strain:COT-022_OH1391 Genome sequencing.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGN98287.1}.
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DR EMBL; JQZW01000008; KGN98287.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A2G786; -.
DR STRING; 266762.HQ36_05170; -.
DR eggNOG; COG0249; Bacteria.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000030134; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000030134}.
FT DOMAIN 682..698
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 490..517
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 608..615
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 872 AA; 98213 MW; 52F20C8784DC145C CRC64;
MRQYFQIKQK HPDAILLFRV GDFYETFVED AVEAARILGI TLTRRANGSA QHVELAGFPH
HALNTYLPRL IAAGKRVAIC DQLEDPKLTK KLVKRGITEL VTPGVAVGDH VLENKENNFL
AAITFGKERI GLSFLDISTG EFSAVEGDDR LIEKLLAGYK PKEILVERKQ RSEYNQRMGD
IHSFVFETDD WLFTPSNNKE RLLQHFGVKS LKGYGLENYP LSITAAGAIL NYLDLTQHTE
IGHITSISRI DEGKFVRLDN FTIHSLELLQ PMNPDGLSLC DILDRTITPM GARLLRRWIA
FPLKEIALIE ERQHIVNHLH NTSSLRLDLK NLFPEIGDLE RMVSKASMKR ITPREVVSLA
NALIAIEEIK KKCAATDNAF LQSLASGLAL CELLRERIKY ELNPDAPQQV NKGNVIAEGY
SEELDELRRL AFSGKDYLLA LQQRESDRTG IPSLKVGFNN VFGYYIEVRN AHKDKVPQEW
IRKQTLVNAE RYITEELKEY EQKILGAEER ILTLETLLFN QLVDDLQESV VALQQNARLL
STLDVLLSFA EVALAQNYVC PVVNDSLILD IKEGRHPVIE QRLPFGEPYI ANDLLLDNNG
CQIMIITGPN MSGKSALLRQ TALITLMAQI GSFVPARSAS IGVVDSIFTR VGASDNISMG
ESTFMVEMQE AASILNNLSS RSLVLFDELG RGTSTFDGIS IAWAIVEHLH NTPLIRPKTL
FATHYHELNE MAQSLSRVRN YSVSAKEVEG QMIFLRKLVE GGNEHSFGIQ VAKLAGMPRS
IVDRASEILK TLESERIQDG VVEREIMAIP GVAKSTKDID RKEEEFQLSF FQMEDPLLLE
IRDDLLAIDI NNLTPIEALN RLNYIKSLLK KY
//
