ID A0A0A2IUY4_PENEN Unreviewed; 2464 AA.
AC A0A0A2IUY4;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=Acyl transferase/acyl hydrolase/lysophospholipase {ECO:0000313|EMBL:KGO58154.1};
GN ORFNames=PEX2_066640 {ECO:0000313|EMBL:KGO58154.1};
OS Penicillium expansum (Blue mold rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=27334 {ECO:0000313|EMBL:KGO58154.1, ECO:0000313|Proteomes:UP000030143};
RN [1] {ECO:0000313|EMBL:KGO58154.1, ECO:0000313|Proteomes:UP000030143}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MD-8 {ECO:0000313|EMBL:KGO58154.1,
RC ECO:0000313|Proteomes:UP000030143};
RX PubMed=25338147; DOI=10.1094/MPMI-09-14-0261-FI;
RA Ballester A.R., Marcet-Houben M., Levin E., Sela N., Selma-Lazaro C.,
RA Carmona L., Wisniewski M., Droby S., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome, transcriptome, and functional analyses of Penicillium expansum
RT provide new insights into secondary metabolism and pathogenicity.";
RL Mol. Plant Microbe Interact. 28:232-248(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGO58154.1}.
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DR EMBL; JQFZ01000121; KGO58154.1; -; Genomic_DNA.
DR RefSeq; XP_016599648.1; XM_016743935.1.
DR STRING; 27334.A0A0A2IUY4; -.
DR GeneID; 27679355; -.
DR HOGENOM; CLU_000022_31_1_1; -.
DR OrthoDB; 5396558at2759; -.
DR PhylomeDB; A0A0A2IUY4; -.
DR Proteomes; UP000030143; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901336; P:lactone biosynthetic process; IEA:UniProt.
DR GO; GO:0030639; P:polyketide biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd05274; KR_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF49; SYNTHASE, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Hydrolase {ECO:0000313|EMBL:KGO58154.1};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000030143};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KGO58154.1}.
FT DOMAIN 20..437
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2377..2455
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2464 AA; 269297 MW; 689C871A4EE21978 CRC64;
MNSTTGQGQS SCRNHEDDFG EPIAIIGMAM RLPGGVRCGD EFWDMLVNKR DGFCEAPPSR
CSREASSSPD CGDLREMKKG FFLQEDPACF DASFFSVPPH EAARLDPQQR LLLEVVWECL
ENSGETKWRG EKIGCFVGVF GEDWLEISHK DPQHLNQIYP IATGSFALAN QVSYRFDLLG
PSMTIQTACS SSLVCLNEAS QALRSGECST ALVGGTSLIW GPTMTDAMTK NMVLSPSGIS
HTFDADADGY GRGEGINCIY LKPLRDALRD NDAIRAVIRS TVTNHDGKTP NFSQPCPISQ
ERLIRHAYQI AGIDAIHETP VFECHGTGTA VGDVIEASVV AKMTQGEVTY ITAVKPNVGH
SEGASGITSI IKSILSLENK TIAPNIHFKT PNPQIPFQDA NLHVPLEPTL WPAGRPQRIS
VNSFGIGGSN AHAILESAST ISPKSQNASL GISDPQLLVI SAHTVETLRK RIAQIVDYVK
NHPSRIHDLS YTLAARRSHL PHRAFAVVHP TKATIDDTAF TIFNTSSPSV TFVFTGQGAQ
WPGMGLRLLS SFPIFKEDIK IMDEALQQLP DGPNWLLYDE LRQESSISRI HEAEFSQPLC
IALQIGLVNI LRGWGIEPST VVGHSSGEIV AAYAARAISM RTAIIIAYYR GKVAKPLEGS
GAMVAVGLTP DEVVPYLTPG VVVACHNSPH SVTLSGDKDS IDRAIKNIKA ANSDTLCRRL
TVKIAYHSDH MKQIGSEYEH CISHHIEYEE AMLPFCSSVT GDTITDPRKL DASYWRQNLE
SPVLFTEAIQ SLPTSGTPVF LEVGPHSALA APLRQIFRIL SARSPVYIPT LFRYEEDVQT
QLLCTAGQAH ATGLGVNLSS ITELGNTLTD LPPYPWQHDR PYWSESRLSR EWRQRAFPHH
EVLGSRVVDT TDHEPSWRNL VTLDNVSWLL DHLIQGAVTF PGAGFVAMVG EAVQQLHPDN
DSYSVRNMTF ITPLLFHEGD QIEMVTSLSP VEVADRVPSG WYGFKIMAHD GERWTMHCQG
QVRAGSDHPP ESFPISSYKR SVPSEGVYRV LQRSGIDYGS QFQGLEKITA DPTGPRATAT
VLGNRGLPGS RYSLHPTAID QCLQLMGVAC SQGLLRHLTT IYVPAMIDSL FVGSGGPPMS
ASARTKRGTR DGQLGDAIAM LGDKVVLSIQ GAYLFALEND NIDSGTGVAG SLAHLEWKSG
IDFLPLSALL STPLDYTAQA MNIKALGQIS VLFVLETADK IEDVEPASPH SAKWKKFIID
AAFNIKTSGR QSIYPESPQW ALLSSSDRQE MIRKVLAETK FTFDAPLVDC TQVVFDNCIA
FTSGESNPLE VLVKDNLLHK FHGAHTQYAD WKPFLPLLCH SNPGLRILEI GAGTGSATAM
ALELLKSPSG ERMYSQYVFT DISSGFMAAA TERFGHEQGM EYKVLDITLD PLEQGFDAHS
FDLIIASNVL HATPSLHPAL CYVHLLLKPT GRFLLHEICP EILTANFTMG VFPGWWLGED
DGRSDQPYIS PERWDRELRA AGFTGADVIA YDHKPPYHVS ASMLSRPVDE ITIPNDIWLL
KSNSTPCEWA SDVELQVRDK GYITNWTTLH ETPPQGKFVV SLLDLQGAPI GSLPKDDYEV
FQRYIEQAQE CQILWVTQST SHTCSDPIFG FIHGLARTLR AELLLDISIL EVPAWDTASA
KAVVQVCEKI QRSRAQSLPD PEYEFALHEG EIKVGRYHWT PLVEQLASPP RSDSSRKLAL
TTYGLLDTLH WAEKEASYEL NEEHVEVEMD YVGLNFKDMM VAMGFFGNKE DLGLEGSGIV
LRVGADVTDI TVGDRVVLMH SGVLASNVVV PHEACIKLPQ GLSMADAATM LTAYVTVLYS
LLEIGALKKG QSVLIHSACG GVGLAALQVC QAVGTEIYAT VGNEKKVAHL MEHFGLPRER
IFNSRNTSFQ PDLMRATAGR GVDVVLNSLS GNLLHASWEC VAKFGRMVEL GKRDFISHGM
LNMSLFEANR AFFGVDLAQV CKETPKILKS TLATFSDWYR QGKIGPIKPV KVFDAIDIVS
AFRYMQAGTH LGKILVRMPT SVESLPPPVV KTFPTFRSDA AYLLIGGLGG IGRSVSTWMV
EQNARELIFL SRSAGKSEED QAFIQELETQ GCQVICVPGN VTNLNNVKEA VATCTRPLAG
ILQMAVDLND RLFLQMSHEE WEAALAPKVA GTWNLHHATL KHSLDFFVVF GSIAGVCGNT
GQANYAAATT FLEAFTRYRR QQGLPSSILH LGVVGDVGAA SRNSRFLQRI QSIGLHVLHE
GEVIDALAAA INISPVSGSN ATGAMAMGLA HTRRRADLPK EIFLGGRDAR FSIYPNLEST
SDGIGGDSSS HANALKALLA QIQADPSLTG KKETEVALMK ELGKFISHNL TGQTQEEGPD
SADDTEALAG MPVDSLMAIE VRNWLRRSLG LEIPTVEINR AGTLGGLVKV VLKGLGEKYD
QRAT
//