ID A0A0A2KFX5_PENIT Unreviewed; 356 AA.
AC A0A0A2KFX5;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Polyketide synthase, enoylreductase {ECO:0000313|EMBL:KGO66717.1};
GN ORFNames=PITC_056100 {ECO:0000313|EMBL:KGO66717.1};
OS Penicillium italicum (Blue mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=40296 {ECO:0000313|EMBL:KGO66717.1, ECO:0000313|Proteomes:UP000030104};
RN [1] {ECO:0000313|EMBL:KGO66717.1, ECO:0000313|Proteomes:UP000030104}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHI-1 {ECO:0000313|EMBL:KGO66717.1,
RC ECO:0000313|Proteomes:UP000030104};
RX PubMed=25338147; DOI=10.1094/MPMI-09-14-0261-FI;
RA Ballester A.R., Marcet-Houben M., Levin E., Sela N., Selma-Lazaro C.,
RA Carmona L., Wisniewski M., Droby S., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome, transcriptome, and functional analyses of Penicillium expansum
RT provide new insights into secondary metabolism and pathogenicity.";
RL Mol. Plant Microbe Interact. 28:232-248(2015).
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGO66717.1}.
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DR EMBL; JQGA01001363; KGO66717.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A2KFX5; -.
DR STRING; 40296.A0A0A2KFX5; -.
DR HOGENOM; CLU_026673_16_1_1; -.
DR OMA; RICGVTH; -.
DR OrthoDB; 2267374at2759; -.
DR PhylomeDB; A0A0A2KFX5; -.
DR Proteomes; UP000030104; Unassembled WGS sequence.
DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR CDD; cd08249; enoyl_reductase_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR047122; Trans-enoyl_RdTase-like.
DR PANTHER; PTHR45348; HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG); 1.
DR PANTHER; PTHR45348:SF2; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000030104}.
FT DOMAIN 13..343
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 356 AA; 38341 MW; F5DB12C5A5926AE8 CRC64;
MATHRAITVQ SQGKAVIQDR LMPQLTDDCI LVKTTAVSLN PTDWKHLDFE ACTGTVIGCD
YAGVVEAVGP AVQKVWKRGD RVAGFIHGCD AVNPANGAFS EYALAKGDLQ IKIPDYMSFE
AACTIGLGIL TVGFGLYHLL GEEMLDDLEN INDKKPAQDQ SASILIYGGA TATGSLAIQV
CKLLGLQVIT TCSEVNRAFM YELGADAVFD YHDAQVGDTI RQGTGDSLEI VFDTISTPQT
AAICAAAISS TGGAYNALLD VRCPRLDVDT NVTMTYDIIG DDYQLGGRNI PGDKINLEFG
VRWVRAAEIL VQSRRIFPHR YAVKPSGLAG ILDGLQLLRQ GKVRACKLVY KLEDTS
//
