ID A0A0A2LJF3_9FLAO Unreviewed; 387 AA.
AC A0A0A2LJF3;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=acetyl-CoA C-acetyltransferase {ECO:0000256|ARBA:ARBA00012705};
DE EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
GN ORFNames=Q763_13830 {ECO:0000313|EMBL:KGO79313.1};
OS Flavobacterium beibuense F44-8.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1406840 {ECO:0000313|EMBL:KGO79313.1, ECO:0000313|Proteomes:UP000030129};
RN [1] {ECO:0000313|EMBL:KGO79313.1, ECO:0000313|Proteomes:UP000030129}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F44-8 {ECO:0000313|EMBL:KGO79313.1,
RC ECO:0000313|Proteomes:UP000030129};
RA Zeng Z., Chen C.;
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGO79313.1}.
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DR EMBL; JRLV01000018; KGO79313.1; -; Genomic_DNA.
DR RefSeq; WP_035135233.1; NZ_JRLV01000018.1.
DR AlphaFoldDB; A0A0A2LJF3; -.
DR STRING; 1406840.Q763_13830; -.
DR eggNOG; COG0183; Bacteria.
DR Proteomes; UP000030129; Unassembled WGS sequence.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919:SF171; ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:KGO79313.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030129};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:KGO79313.1}.
FT DOMAIN 4..256
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 263..384
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 88
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 342
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 372
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 387 AA; 40693 MW; 71CE4420FA41CC5C CRC64;
MKDVFIVAAK RTPVGGFLGS LSGFTATQLG KTAIEAIMND VKLPADKVEA VYMGNVLSAN
LGQSPARQAA VFAGIPVDAD ATTVNKVCAS GLKAVITAAQ QVQLGVNNVV VAGGMESMSN
VPHYIDGRKS TKLGHTQVTD GLLKDGLTDV YNGFHMGNAA EICAREYKLT REQQDDYALK
SYKRAADAFN AGKFSDEIIP IEVNGNVINS DEDIFKLIPE KVARLKPVFE EGGTITAANA
SNLNDGAAAL LLVSEEVVKE YNLKPLAKIK GYADAAQAPE WFTTSPSVAI PKALQQARLT
KEDIDYYEIN EAYAAVILAN AKILGLDMEK INVYGGGVAM GHPIGASGAR IVVTLLSVLK
QEGGKYGVAA ICNGGGGASA LVIENLQ
//
