ID A0A0A2V2X4_PARBA Unreviewed; 574 AA.
AC A0A0A2V2X4;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Elongation factor 1-alpha {ECO:0000256|ARBA:ARBA00013870};
GN ORFNames=PAAG_11418 {ECO:0000313|EMBL:KGQ01843.1};
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779 {ECO:0000313|EMBL:KGQ01843.1, ECO:0000313|Proteomes:UP000002059};
RN [1] {ECO:0000313|EMBL:KGQ01843.1, ECO:0000313|Proteomes:UP000002059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249}.
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DR EMBL; KN293995; KGQ01843.1; -; Genomic_DNA.
DR RefSeq; XP_015703333.1; XM_015847071.1.
DR AlphaFoldDB; A0A0A2V2X4; -.
DR STRING; 502779.A0A0A2V2X4; -.
DR GeneID; 9099279; -.
DR KEGG; pbl:PAAG_11418; -.
DR VEuPathDB; FungiDB:PAAG_11418; -.
DR eggNOG; KOG0052; Eukaryota.
DR HOGENOM; CLU_007265_3_5_1; -.
DR OMA; RDMGQTV; -.
DR OrthoDB; 5477300at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd03693; EF1_alpha_II; 1.
DR CDD; cd03705; EF1_alpha_III; 1.
DR Gene3D; 2.20.25.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR HAMAP; MF_00118_A; EF_Tu_A; 1.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004539; Transl_elong_EF1A_euk/arc.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR InterPro; IPR001222; Znf_TFIIS.
DR NCBIfam; TIGR00483; EF-1_alpha; 1.
DR PANTHER; PTHR23115:SF170; ELONGATION FACTOR 1-ALPHA 2; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR Pfam; PF01096; TFIIS_C; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00440; ZnF_C2C2; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
DR PROSITE; PS51133; ZF_TFIIS_2; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000313|EMBL:KGQ01843.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:KGQ01843.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00472}.
FT DOMAIN 84..158
FT /note="TFIIS-type"
FT /evidence="ECO:0000259|PROSITE:PS51133"
FT DOMAIN 120..355
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 574 AA; 63406 MW; 668C04986CADAF08 CRC64;
MTRNDLPDRD RLYISVCPNC SNALTISRAE PTSRYPLGVN RFECRTCPYQ YILDRTYYER
TEMKRKEVAD VLGGKDEWKN ADSIGTQCPA EGCDGDRAFF YQLQIRSADE PMTTFLKEEK
THINLVVIGH VDSGKSTTTG HLIYKCGGID SRTIEKFEKE AEELGKKSFK YAWVLDKLKA
ERERGITIDI ALWKFETPKY NVTVIDAPGH RDFIKNMITG TSQADCAILI IAAGTGEFEA
GISKDGQTRE HALLAFTLGV KQLIVAINKM DTTKWSETRF NEIIKEVTNF IKKVGYNPKT
VPFVPISGFE GDNMIEPSAN CPWYKGWSKE TAQGKYSGKT LLEAIDAIEP PTRPTDKPLR
LPLQDVYKIS GIGTVPVGRV ETGVIKPGMV VTFAPANVTT EVKSVEMHHQ QLTAGNPGDN
VGFNVKNVSV KEVRRGNVAG DSKNDPPKGC DSFNAQVIVL NHPGQVGAGY APVLDCHTAH
IACKFAELLE KIDRRTGKSV ENNPKFIKSG DAAIVKMIPS KPMCVEAFTE YPPLGRFAVR
DMRRTVAVGV IKSVVKSDKA GGKVTKAAQK ATKK
//
