ID A0A0A2V336_PARBA Unreviewed; 1861 AA.
AC A0A0A2V336;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=PAAG_12542 {ECO:0000313|EMBL:KGQ00782.1};
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779 {ECO:0000313|EMBL:KGQ00782.1, ECO:0000313|Proteomes:UP000002059};
RN [1] {ECO:0000313|EMBL:KGQ00782.1, ECO:0000313|Proteomes:UP000002059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000256|ARBA:ARBA00008842,
CC ECO:0000256|RuleBase:RU003844}.
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DR EMBL; KN294023; KGQ00782.1; -; Genomic_DNA.
DR RefSeq; XP_015702360.1; XM_015848020.1.
DR AlphaFoldDB; A0A0A2V336; -.
DR STRING; 502779.A0A0A2V336; -.
DR GeneID; 9092994; -.
DR KEGG; pbl:PAAG_12542; -.
DR VEuPathDB; FungiDB:PAAG_12542; -.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG1737; Eukaryota.
DR HOGENOM; CLU_001040_3_0_1; -.
DR OMA; SIRQMWE; -.
DR OrthoDB; 960at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13292; PH_Osh1p_Osh2p_yeast; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR046824; Mss51-like_C.
DR InterPro; IPR032717; Mss51_Znf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972:SF205; OXYSTEROL-BINDING PROTEIN; 1.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF20179; MSS51_C; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF13824; zf-Mss51; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW Transferase {ECO:0000256|ARBA:ARBA00022676};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT REPEAT 283..306
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 390..422
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 483..578
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 137..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1471..1503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..836
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1861 AA; 209603 MW; 4ECE9BEDE7B3C6E0 CRC64;
MITTNQRRSS DVVDATERSV ISQFPVPATF SLKSLHLLLF NHLLLQVVIA SIAHQPSSPE
IPLSTNEWTP HTVRTSGRIA CIQHLLEHMS EEIGHKRSKS ALAHSFLHRA KCRSGLQEDP
EILLANREQY GASATMDPKA LSVPPASDGS CPSHSNSTSM TNLCATRQQT DTLSLNKSPG
GNAGSTTASH EQPPSGGRGE VLTRSAMSIE QSVRTFRLFE ILRSGDTTAI SKAIKECAEP
QSQGTPPLGT SILHLAIQCV EPQVVEYILS SSSNLDINAR DRDGNTPLHL AAQLGRAPIV
RELLERPDIN DSVTNYNGQI PLDLARTPEI FQQLQLARSI FLDAKTKEMQ CLIGQGEYER
LERLLVEPRV EGLLDVNSLD LVTDRTTVMT GGTLLHEAAR KKDTKLIQIL LMHGADPFRR
DRKGKLPQDV TKDDRTRAIV KRSPAAMIAQ RGIQEKAILG SAAGQGNPLR SGVGEAGVGG
KDAREMKGYL KKWTNYTSGY KLRWFVLEDG VMSYYKHQDD AGSACRGAIN MRIATLHMDA
QDKTRFEIQG KSSVKYHLKA NHVVEAKRWF WALNNAIQWT KDEAKEDDRR RTRNAESLRQ
AMLEQFDKQG LDSQSDSASV VGRPSGKNLA PQSSLGVLSH ASSRLSLQTS RGGTESIRGE
DESSNYVPNE STFSPQENNK LPTLLTSHVL QGEAEDDDCG DYASSNELQP SNKDAFNITA
QSVRLQLYLL SNVSAALQAE KVRNPETRIS DPSIDQALNA YEGAVSSLNS LVVDLLKISR
DRDAFWQYRL DREADALKMW EDSMARVAQE HEELQSRIGE SEEKRKRTKK ALKEALEHPS
TSTSRPISRG PSHVQIQDAL EVVKETVTEK LAFTERKASK ELRRKKSLIT ELTNLSDSES
DEDEEFFDAV DAGEVKIVEV PPEKVVEAQD SVSNIRASKL DEIAPSFKGY EDPIRKRLKM
DADDRPKISL WAILKSMIGK DMTKMTLPVS FNEPTSLLQR VAEDMEYADL LDLAADRADS
MERMIYVAAF AASEYASTID RVAKPFNPLL GETFEYVRPD KGYRFFIEQV SHHPPIGAAW
AESPKWDYYG ESAVKSKFYG KSFDINPLGT WFLRLRPISG GEELYTWKKI TSSVVGIITG
NPTVDNYGSM EIKNWTTGEV CMLDFKPRGW KASSAYHVSG KVMDSEGSTK WSIGGRWNDK
IYARHTPGYQ ESVTPPHDDT PQHPESTRAF LVWQCHPRPT GIPFNLTPFV LTLNAIPDNL
KPHLPPTDTR LRPDQRAMED GEYDFAATEK HRVEEKQRAK RRERETKGEE FEPKWFSKGR
CKITGEEFWV YNGRYWKCRE ANDWSFPMVM EFTCQKCAQA LRLGIRPQIP SIRVRTLSNV
GRRYQHLSTN ASSLQASKAG SWSTKVRAET TTITNVASLS ASEPTTTGAS EAYHGRPLLQ
PHNLFHSYSN SPSPEIRQRA AFIAQNAFCP HPSHRRTRVP TSPYDSEARK SPEASSDSQP
PLHSQFECPD CGVPIYCSEE HWMDDFEAHL EVCHTIRQIN EDDHDLRSGR FFTEFIYPGP
QEDESVVNMT NWDTFLYTRQ FDAINNDRNM RQVTRLLTYP VTIASVLHEL SPYHIRNGGR
LTPEGLKSLS ALRYTLHPPR TGEGAAMSGL RLKAPPVRIF ILGARAESSL PRDVWLQLSY
LFPRALISLI FIGPESMANR DDEFPLPDRT PSNPFGAIVE DRLHSLMKIT TYVDYFHTIH
RANMFQPYDP YFDCFMLFHP GLGHPSSSHE WEETLPYLLE TKVPILCTGY SEWDMKRDLD
WVMEKCGGEV DLLLEPGENR FRSLRWDLND MDPHDISCGN WGLWVFRGKR YEATYKESEA
E
//
