ID A0A0A2V655_PARBA Unreviewed; 1287 AA.
AC A0A0A2V655;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Cyclin-like domain-containing protein {ECO:0000259|SMART:SM00385};
GN ORFNames=PAAG_11395 {ECO:0000313|EMBL:KGQ01822.1};
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779 {ECO:0000313|EMBL:KGQ01822.1, ECO:0000313|Proteomes:UP000002059};
RN [1] {ECO:0000313|EMBL:KGQ01822.1, ECO:0000313|Proteomes:UP000002059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex. The SRB8-11 complex
CC phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC RNA polymerase II. {ECO:0000256|ARBA:ARBA00025278}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, a regulatory module of the
CC Mediator complex. {ECO:0000256|ARBA:ARBA00011612}.
CC -!- SIMILARITY: Belongs to the cyclin family.
CC {ECO:0000256|RuleBase:RU000383}.
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DR EMBL; KN293995; KGQ01822.1; -; Genomic_DNA.
DR RefSeq; XP_015703315.1; XM_015847053.1.
DR AlphaFoldDB; A0A0A2V655; -.
DR STRING; 502779.A0A0A2V655; -.
DR GeneID; 9099230; -.
DR KEGG; pbl:PAAG_11395; -.
DR VEuPathDB; FungiDB:PAAG_11395; -.
DR eggNOG; KOG0834; Eukaryota.
DR eggNOG; KOG2069; Eukaryota.
DR HOGENOM; CLU_276213_0_0_1; -.
DR OMA; MEEVAMS; -.
DR OrthoDB; 4848277at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20545; CYCLIN_SpCG1C-like_rpt1; 1.
DR CDD; cd20546; CYCLIN_SpCG1C_ScCTK2-like_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR019194; Tscrpt_elong_fac_Eaf_N.
DR PANTHER; PTHR10026; CYCLIN; 1.
DR PANTHER; PTHR10026:SF51; CYCLIN-T; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR Pfam; PF09816; EAF; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cyclin {ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 646..752
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 765..852
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 157..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..1273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..235
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..902
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1081
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1259..1273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1287 AA; 142695 MW; 446F72BDF8606A67 CRC64;
MATLASSATP LPNGGLIDPT KQAEYPILLG DKLARREEAS SNGFISVTYN HKSKSASRQQ
RATITASKSS RHLYKLTLQD KGPNADQNIV HTYQGSVDPT SPVSVSETGN LVLVFDPKRK
AFILEPVMTR LNFNLRSAPG KSTQQVTEQY PQLNVLSGED HVSGDDLLLE KPGEDDSEGA
PDDSNPYDFR HFLPKSKADD DIPESITPDP HQVTASQPAS RLAPPQPPPL SSGKPRPKPA
AKAKPQTNPL RPLKRLPKSI TNPKIPTIPK PQSAPLVEEV GLVLDSASDG ASDGASDGAS
DEEEEETTTQ NVVDNTASQP AASPGANIIV DGDLIIDMGS PPPARPAFKI NPRHFSSNNT
SANEADYDSD DEGEIEDLRL PSPAGASYHG HEEDEKEEDE EEEQERERER GETRQDDVID
DDDLAAEMEA AFEESAREEE QERAQQLLLQ QQMQHHIVSE DESERSNVDP DRNYPSSNSL
TFTFIFRVST PTYNAKHSRK APYLLEFTTT TPGRELLRSA IIPHDLSGSC PLQGTCVLSE
REMTSDHLTL IVTLRQHLQL VSELAVLPCE VAQYRLLALF LRLSNMSATS TSKRMSLPPV
PSPSNPILVA TQSQWIFTDS ELHRTPSILD GMTMEAEHTS RSKGVNFITQ VGILLKLPQL
TLCTASVYLH RFFMRYSMKD LPQRPGMHPY SVAATSLFLA TKVEENCRKM KELIVACCRV
AQKKPSMVVD EQSKEFWRWR DTILHNEDLL LEALCFDLQL EQPYRLLYDF ICYFKVQGNK
RLRNSAWAFL NDSTYTVLCV QFPARTIAAA ALYAAARHCE VTFEDDALNR PWWEQLDVDL
NEMRRACNRM ADIYEFVSVP VPGQQYAHLS TGDDGATDQT RTSHQPKSES SMDISANSMS
PGEINGRKRE RDNHSDSFSQ YPISLPANGT TSGTQDPQPS PKRQRREGSE VDADTAPFSQ
TQPPLSSQTS FVQAAPNLNM RTATNDPSSQ IPSEINGHPR NVSPPKSRIP QAARIPANVA
RQEHPLPPPP PVTVPPLPHQ HSPPPRRASY ANNPPPPPRG PPLSSGPSMF HPPPPPPPSN
SSSVDELQQR IDAIIQQGLP RDNDRSHEPR GSYHYHPPSR DRDGNREKDR DRYLDSDIDR
SRERDRYRER GIDKDREKEK DKGRDYDRDF NCSRRQSSEA SGSVAISASL SAPSFSGAPP
ATVLPPPLAP SADTRKESGQ DQQEKGEAVN EDTTTKTTVS QVIGNNSAEP DDGGSEEEQW
VVDDGHNVDS VKRPFRDKGT LRFYADI
//