ID A0A0A2W330_BEABA Unreviewed; 2268 AA.
AC A0A0A2W330;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Cyclic di-GMP-binding protein {ECO:0000256|ARBA:ARBA00021844};
DE AltName: Full=Cellulose synthase regulatory subunit {ECO:0000256|ARBA:ARBA00033444};
GN ORFNames=BBAD15_g1221 {ECO:0000313|EMBL:KGQ13032.1};
OS Beauveria bassiana D1-5.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=1245745 {ECO:0000313|EMBL:KGQ13032.1, ECO:0000313|Proteomes:UP000030106};
RN [1] {ECO:0000313|EMBL:KGQ13032.1, ECO:0000313|Proteomes:UP000030106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D1-5 {ECO:0000313|EMBL:KGQ13032.1,
RC ECO:0000313|Proteomes:UP000030106};
RA Li Q., Wang L., Zhang Z., Wang Q., Ren J., Wang M., Xu W., Wang J., Lu Y.,
RA Du Q., Sun Z.;
RT "Genome sequencing and analysis of entomopathogenic fungi Beauveria
RT bassiana D1-5.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Binds the cellulose synthase activator, bis-(3'-5') cyclic
CC diguanylic acid (c-di-GMP). {ECO:0000256|ARBA:ARBA00002057}.
CC -!- PATHWAY: Glycan metabolism; bacterial cellulose biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005186}.
CC -!- SUBUNIT: Tightly associated with the cellulose synthase catalytic
CC subunit. {ECO:0000256|ARBA:ARBA00011437}.
CC -!- SIMILARITY: Belongs to the AcsB/BcsB family.
CC {ECO:0000256|ARBA:ARBA00010714}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 8 (cellulase D) family.
CC {ECO:0000256|ARBA:ARBA00009209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGQ13032.1}.
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DR EMBL; ANFO01000064; KGQ13032.1; -; Genomic_DNA.
DR HOGENOM; CLU_230478_0_0_1; -.
DR UniPathway; UPA00694; -.
DR Proteomes; UP000030106; Unassembled WGS sequence.
DR GO; GO:0019867; C:outer membrane; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0030244; P:cellulose biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR008410; BCSC_C.
DR InterPro; IPR003920; Cell_synth_B.
DR InterPro; IPR018513; Cell_synthase_bac.
DR InterPro; IPR002037; Glyco_hydro_8.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR39083; CYCLIC DI-GMP-BINDING PROTEIN; 1.
DR PANTHER; PTHR39083:SF1; CYCLIC DI-GMP-BINDING PROTEIN; 1.
DR Pfam; PF03170; BcsB; 1.
DR Pfam; PF05420; BCSC_C; 1.
DR Pfam; PF01270; Glyco_hydro_8; 1.
DR Pfam; PF14559; TPR_19; 2.
DR Pfam; PF13181; TPR_8; 1.
DR PRINTS; PR01440; CELLSNTHASEB.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
DR SUPFAM; SSF48452; TPR-like; 4.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW c-di-GMP {ECO:0000256|ARBA:ARBA00022636};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cellulose biosynthesis {ECO:0000256|ARBA:ARBA00022916};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000030106};
KW Signal {ECO:0000256|SAM:SignalP};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2268
FT /note="Cyclic di-GMP-binding protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001996376"
FT REPEAT 1406..1439
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1908..2248
FT /note="Cellulose synthase operon C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05420"
FT REGION 2173..2202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2268 AA; 250493 MW; 11D739F205B7DFB3 CRC64;
MKRKISWFYA AAVGISALPV TVANAADTTP APTVPAVATA NQAVITPAPG AAEALVPATP
ADNAPTVGQV LPGVQGANAP IVAENVPSRD VKLNFAQIAP PPGSMVLTGV NPNGGVEFGM
RRDEIVSKAL LNLEYTPSPS LLPVQSQLKV YLNDELMGVL PVTKEQLGKK TFAQVPVDPL
YITDFNRVRL EFVGHYRDIC ENPASTTLWM DVGRSSSLAL TYQRLPVQND LSHFPVPFFD
SRDDRPLTLP IVFAASPDIE QQRAAGIVAS WFGSRTAWRG QNFPVLFNQL PTSNGIVFAT
NDKRPDFLRN HPAVQAPTVE MMSHPDNPYV KLLVVMGRDD KDLVQAAKGI AQGNILFRGS
SVTVDDVKPL LPREPYDAPN WVRTDRPVTL GEMKTYQEQL QSSGQEPSAI SVTMNLPPDL
YLLRSNGIDL NLKYRYTAPA MKDSSRMDIS LNNQFLQSFN LTPSEENNKL LLRLPVLQGL
LDGKTDVSIP ALRLGAANQL RFDFSYMNPM PGGSLENCVT FQPVQNHVVV EDESTIDFSN
YHHFIAMPDL RTFANAGFPF SRMADLSQTI VVVSKEPDPA QVTALLDALG TIGSQTGFPA
LSVNLTDDGS TIQGKDADIM IIGSIPPALK DDKRIDLLVD ATQSWVKTPV RQTPLLNSVS
DPKDRAADTQ TAITSQGAMA AIVGFQSPYN DQRSVLALLA DSPRGYELLN SALNDSGKRA
AISGSVAVIR ESGVDSLRVG DIYYVGHLPW FERIWYALSN HPVLLAIFAA ISVVLLAWVL
WRILRILSRR RIDPEDDYVS DQGRVIDPSD ERKITTSEGQ SYGLFFALAA NDRAMFDQLL
RWTENNLAQG ALKDHLPAWL WGKNDKDEWT VLDSNSASDA DMWIVWSLLE AGRLWHEPAY
KRLGEQLLKR VAKEEVIKIP GLGFSLLPGR VGFNHSPDWR LNPSYLPPQV LQRMVRYRGP
WSAMQVANQR LLLETAAKGF SPNWADWHEG KGWQFQTDDA RYGSYDSIRV YMWVGMMADD
APHKAALLKA FQPMADITIK QGLPPEKVDV QTGNVQGTGP VGFSAAMLPF LQDSEARDVQ
RQRVKDNFPQ ADAYYSYVLT LFGQGWDQKR FRFNSLGELI PSWGQAALTP QQQLLEQVRM
GEASKREDIV RQSLSRLELM APDDPDVIAA RMRYLLRQGD NAGAKAQLER LAKLAPGSAE
YKQSQVTLML TGADGRQQLQ QARLLAASGH TDQAIAAYEK LFDGNPPEGD LAIEYWMLMA
KRPATTNQAI DKLKALDAAA PGNAELRGNL ARLMFANGRS AEAYQVLEQM AKSSGSREDA
AALWYSQISN LPTGPQSVAA LQRFLNVFTE GDTVASARDK LAQQQKQLAD PAFLARAKGL
EDVGGGRGNQ AIPQLKEALS TKQNDSEVVG ALGQAYSQQG KRALAVQQFE KAIQMDPQSD
NRGKWDSLLK TNRYWLLIEQ GDAQLKANNP DAALQKYQLA QRIDNTDSYA VLGFGDVAVA
KKDDASAERY YQQALRMDRG NSNAIRGLAN VYRRQSPERA AAYIQSLSAS QRKSIDDIER
SLAGERLEQQ ATALESQGQW AKAAEIQRRR LQLDPDSVWI TYRLSNDLYA AGKHSEADSL
MRGLAQRKPG DPEQVFAYGL YLSGNDHDAA ALSHLNTLPK AQWTDNIHEL ADRLQFNEVM
QTANRLRDSG KEKDAIALLQ QQTPSDRVDL TLSDWAAERG DRATAKSQYQ KVLQRSPGNE
DALLGLTEVL IAEGDKPQAR GLLAKLQEAP TGDTPSINTQ RRIANAWAAL GDNEKAAQTY
APILVAAKTQ PPSMESALVM RDAARFQAAS GQPQQALETY KDAMVSSGIT RQRPQDNDTF
TRLTRNDEKD DWLKRGVRSD AADLYRQQDV NVTLDHEYWG SSGTPGYSDL KAHTTMLQVD
APLSDGRMWF RTDMVNMDAG SFKDNGAGYN ERWGTCAKHN CFGNRRQSGN GASVAVGWKN
NTWQTDIGTT PMGFDVVDVV GGVSYSNDLG PIGYTVNAHR RPISSSLLSF GGQRDPNTKT
VWGGVRATGG GVSLSYDKGE ANGVWSSLSA DTLTGKNVAD NWRVRWMTGY YYKLINENNQ
RLTVGLTNMV WHYEKDLSDY FLGQGGYYSP QKYVSFAVPV IWRKRTENWS WELGASGSWS
YSHSNAGQRY PLRNLVPNNT NDYPEDPYAY PDRNDPSSAS SSNGFGYTAR ALVERRISSH
WSIGAGIDIQ QAKDYTPSHA LIYVRYSMAG WQGDMDMPPQ PLVPYADF
//
